SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rfo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 479
LEU A 483
SER A 512
LEU A 513
 None
 0.83A 1a4lC-2rfoA:
undetectable		 1a4lC-2rfoA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 339
ASP A 434
GLU A 433
PHE A 308
 None
 1.12A 1b2iA-2rfoA:
undetectable		 1b2iA-2rfoA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 723
ILE A 767
LEU A 716
ILE A 720
THR A 778
 None
 1.01A 1dhiB-2rfoA:
undetectable		 1dhiB-2rfoA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 723
ILE A 767
LEU A 716
ILE A 720
THR A 778
 None
 0.94A 1dhjB-2rfoA:
undetectable		 1dhjB-2rfoA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 723
ILE A 767
LEU A 716
ILE A 720
THR A 778
 None
 1.04A 1draB-2rfoA:
undetectable		 1draB-2rfoA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 723
ILE A 767
LEU A 716
ILE A 720
THR A 778
 None
 0.98A 1drbB-2rfoA:
undetectable		 1drbB-2rfoA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 242
ILE A 241
ALA A 245
ILE A 207
 None
 0.97A 1oniB-2rfoA:
undetectable
1oniC-2rfoA:
undetectable		 1oniB-2rfoA:
11.98
1oniC-2rfoA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 579
LEU A 576
VAL A 588
GLY A 591
ARG A 599
 None
 1.13A 1y4lB-2rfoA:
undetectable		 1y4lB-2rfoA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 513
LEU A 260
ILE A 234
ILE A 508
ALA A 507
 None
 1.08A 2bxcA-2rfoA:
undetectable		 2bxcA-2rfoA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 513
LEU A 260
ILE A 234
ILE A 508
ALA A 507
 None
 1.02A 2bxqA-2rfoA:
undetectable		 2bxqA-2rfoA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 723
ILE A 767
LEU A 716
ILE A 720
THR A 778
 None
 1.03A 2drcB-2rfoA:
undetectable		 2drcB-2rfoA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 629
GLU A 633
GLN A 626
 None
 1.04A 2p16A-2rfoA:
undetectable		 2p16A-2rfoA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIV_A_T3A933_1
(ANDROGEN RECEPTOR)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 239
PHE A 238
GLU A 210
ASN A 214
TYR A 215
 None
 0.80A 2pivA-2rfoA:
0.0		 2pivA-2rfoA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 341
VAL A 411
ILE A 415
ILE A 346
 None
 0.90A 2piwA-2rfoA:
undetectable		 2piwA-2rfoA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 532
GLY A 489
LEU A 515
PHE A 516
 None
 1.01A 2vctD-2rfoA:
2.5		 2vctD-2rfoA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 4 TYR A 556
LEU A 557
LEU A 538
HIS A 505
 None
 1.46A 2x7hB-2rfoA:
undetectable		 2x7hB-2rfoA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 252
ILE A 432
SER A 256
TYR A 478
 None
 1.18A 2xz5D-2rfoA:
undetectable
2xz5E-2rfoA:
undetectable		 2xz5D-2rfoA:
16.64
2xz5E-2rfoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 723
ILE A 767
LEU A 716
ILE A 720
THR A 778
 None
 1.04A 3drcB-2rfoA:
undetectable		 3drcB-2rfoA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		3 / 3 SER A 421
ASP A 419
ASN A 395
 None
 0.87A 3lsfB-2rfoA:
undetectable
3lsfE-2rfoA:
undetectable		 3lsfB-2rfoA:
17.21
3lsfE-2rfoA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 419
ASN A 395
SER A 421
 None
 0.86A 3lsfB-2rfoA:
undetectable
3lsfE-2rfoA:
undetectable		 3lsfB-2rfoA:
17.21
3lsfE-2rfoA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		3 / 4 SER A 377
GLY A 416
GLU A 393
 None
 0.62A 3raeA-2rfoA:
undetectable
3raeC-2rfoA:
undetectable		 3raeA-2rfoA:
22.25
3raeC-2rfoA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 723
ILE A 767
LEU A 716
ILE A 720
THR A 778
 None
 1.00A 4dfrB-2rfoA:
undetectable		 4dfrB-2rfoA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 477
TYR A 277
LEU A 278
ARG A 342
 None
 1.44A 4em2A-2rfoA:
0.0		 4em2A-2rfoA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 723
ILE A 767
LEU A 716
ILE A 720
THR A 778
 None
 1.09A 4pthA-2rfoA:
undetectable		 4pthA-2rfoA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 541
PHE A 534
ILE A 537
GLY A 509
PHE A 212
 None
 1.21A 4zdyA-2rfoA:
undetectable		 4zdyA-2rfoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 556
PHE A 534
ILE A 537
GLY A 509
 None
 0.87A 4ze3A-2rfoA:
undetectable		 4ze3A-2rfoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 556
PHE A 534
ILE A 537
GLY A 509
 None
 0.81A 5eseA-2rfoA:
undetectable		 5eseA-2rfoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 556
PHE A 534
ILE A 537
GLY A 509
 None
 0.75A 5esfA-2rfoA:
undetectable		 5esfA-2rfoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 556
PHE A 534
ILE A 537
GLY A 509
 None
 0.83A 5esjA-2rfoA:
undetectable		 5esjA-2rfoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 541
PHE A 534
ILE A 537
GLY A 509
PHE A 212
 None
 1.18A 5eskA-2rfoA:
undetectable		 5eskA-2rfoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 541
PHE A 534
ILE A 537
GLY A 509
PHE A 212
 None
 1.19A 5eslA-2rfoA:
undetectable		 5eslA-2rfoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 556
PHE A 534
ILE A 537
GLY A 509
 None
 0.75A 5esmA-2rfoA:
undetectable		 5esmA-2rfoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 503
HIS A 505
LEU A 506
TYR A 556
LEU A 538
 None
 1.11A 5k9dA-2rfoA:
undetectable		 5k9dA-2rfoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 322
VAL A 327
SER A 323
ILE A 425
ALA A 427
 None
 0.99A 5n0sB-2rfoA:
undetectable		 5n0sB-2rfoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 219
GLU A 555
HIS A 505
ALA A 216
PHE A 212
 None
 1.35A 5nd2B-2rfoA:
undetectable		 5nd2B-2rfoA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 724
THR A 664
ASP A 663
LEU A 661
 None
 1.12A 5tdzA-2rfoA:
undetectable		 5tdzA-2rfoA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 579
LEU A 557
LEU A 610
GLU A 606
 None
 0.90A 5tudD-2rfoA:
undetectable		 5tudD-2rfoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 660
ASP A 765
ILE A 767
 None
 0.52A 6dh0B-2rfoA:
undetectable		 6dh0B-2rfoA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 596
TYR A 650
GLU A 648
GLU A 605
 None
 1.24A 6mn5A-2rfoA:
undetectable		 6mn5A-2rfoA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 596
TYR A 650
GLU A 648
GLU A 605
 None
 1.17A 6mn5B-2rfoA:
undetectable		 6mn5B-2rfoA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2rfo NUCLEOPORIN NIC96
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 596
TYR A 650
GLU A 648
GLU A 605
 None
 1.21A 6mn5C-2rfoA:
undetectable		 6mn5C-2rfoA:
9.47