SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rfq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 THR A 236
THR A 237
PRO A 235
 None
 0.78A 1a7yA-2rfqA:
undetectable		 1a7yA-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 THR A 236
THR A 237
PRO A 235
 None
 0.87A 1a7yB-2rfqA:
undetectable		 1a7yB-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 THR A 237
PRO A 235
THR A 236
 None
 0.76A 1i3wE-2rfqA:
undetectable		 1i3wE-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 THR A 236
THR A 237
PRO A 235
 None
 0.86A 1i3wE-2rfqA:
undetectable		 1i3wE-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 THR A 236
THR A 237
PRO A 235
 None
 0.78A 1i3wF-2rfqA:
undetectable		 1i3wF-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 THR A 237
PRO A 235
THR A 236
 None
 0.84A 1i3wG-2rfqA:
undetectable		 1i3wG-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 THR A 237
PRO A 235
THR A 236
 None
 0.82A 1mnvD-2rfqA:
undetectable		 1mnvD-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 THR A 236
THR A 237
PRO A 235
 None
 0.79A 1mnvD-2rfqA:
undetectable		 1mnvD-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 THR A 237
PRO A 235
THR A 236
 None
 0.78A 1ovfB-2rfqA:
undetectable		 1ovfB-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 THR A 236
THR A 237
PRO A 235
 None
 0.77A 1qfiA-2rfqA:
undetectable		 1qfiA-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 THR A 236
THR A 237
PRO A 235
 None
 0.79A 1unjF-2rfqA:
undetectable		 1unjF-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		4 / 8 VAL A 104
ASP A 108
PRO A 169
LEU A 167
 None
 1.01A 1z2bB-2rfqA:
undetectable		 1z2bB-2rfqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		5 / 12 LEU A  95
SER A 206
LEU A 205
VAL A 164
ASP A 162
 None
 1.16A 2c12C-2rfqA:
31.1		 2c12C-2rfqA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		4 / 8 PHE A 338
SER A 341
ALA A 347
LEU A 346
 None
1PS  A 392 ( 4.1A)
1PS  A 392 ( 3.8A)
None
 1.01A 2o01A-2rfqA:
undetectable		 2o01A-2rfqA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 SER A  37
THR A  44
PHE A  65
 None
 0.69A 2x91A-2rfqA:
3.5		 2x91A-2rfqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		5 / 12 MET A 245
ASP A 358
LEU A 184
ILE A  33
MET A  38
 None
 1.48A 3g4lD-2rfqA:
undetectable		 3g4lD-2rfqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 ASN A  90
MET A  10
PHE A  65
 None
 0.52A 3g4lD-2rfqA:
undetectable		 3g4lD-2rfqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 ARG A  48
GLU A  53
TYR A 226
 None
 0.87A 3k37B-2rfqA:
undetectable		 3k37B-2rfqA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 SER A 140
SER A 139
HIS A 144
 None
 0.69A 3mzeA-2rfqA:
undetectable		 3mzeA-2rfqA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		3 / 3 SER A 189
SER A 139
HIS A 144
 None
 0.80A 3mzeA-2rfqA:
undetectable		 3mzeA-2rfqA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		5 / 12 SER A  84
ASP A  61
PHE A  65
VAL A 298
ALA A 299
 None
 1.24A 4foxD-2rfqA:
undetectable		 4foxD-2rfqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		5 / 12 GLY A 134
ALA A 137
PHE A 166
VAL A 194
ILE A 168
 None
 1.08A 4rvdA-2rfqA:
undetectable		 4rvdA-2rfqA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		5 / 12 GLY A 134
ALA A 137
PHE A 166
VAL A 194
ILE A 168
 None
 1.08A 4rvgA-2rfqA:
undetectable		 4rvgA-2rfqA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		4 / 6 PHE A  65
PRO A  62
THR A 236
ILE A 233
 None
 0.90A 5ih0A-2rfqA:
undetectable		 5ih0A-2rfqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		5 / 11 VAL A 104
ASP A 108
THR A 109
PRO A 169
LEU A 167
 None
 1.32A 5jh7B-2rfqA:
undetectable		 5jh7B-2rfqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		5 / 11 VAL A 104
ASP A 108
THR A 109
PRO A 169
LEU A 167
 None
 1.37A 5jh7D-2rfqA:
undetectable		 5jh7D-2rfqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2rfq 3-HSA HYDROXYLASE,
OXYGENASE
(Rhodococcus
jostii) 		4 / 6 ARG A  48
LEU A  49
ALA A  68
GLN A  51
 None
 1.04A 6b89B-2rfqA:
undetectable		 6b89B-2rfqA:
14.21