SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JTV_A_TESA500_1 (17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1)	2rfr	UNCHARACTERIZED PROTEIN (Novosphingobium aromaticivorans)	4 / 8	VAL A 51 TYR A 27 HIS A 82 VAL A 104	None	1.19A	1jtvA-2rfrA: undetectable	1jtvA-2rfrA: 21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q6F_C_010C6_0 (INFECTIOUS BRONCHITIS VIRUS (IBV) MAIN PROTEASE N-[(5-METHYLISOXAZOL -3-YL)CARBONYL]ALANY L-L-VALYL-N~1~-((1R, 2Z)-4-(BENZYLOXY)-4- OXO-1-{[(3R)-2-OXOPY RROLIDIN-3-YL]METHYL }BUT-2-ENYL)-L-LEUCI NAMIDE)	2rfr	UNCHARACTERIZED PROTEIN (Novosphingobium aromaticivorans)	3 / 3	ASN A 120 LEU A 151 HIS A 101	None	0.84A	2q6fB-2rfrA: undetectable	2q6fB-2rfrA: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QHF_A_ACTA507_0 (CHORISMATE SYNTHASE)	2rfr	UNCHARACTERIZED PROTEIN (Novosphingobium aromaticivorans)	3 / 3	LEU A 140 ASN A 138 ARG A 116	None	0.87A	2qhfA-2rfrA: undetectable	2qhfA-2rfrA: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A2Q_A_ACAA602_1 (6-AMINOHEXANOATE-CYC LIC-DIMER HYDROLASE)	2rfr	UNCHARACTERIZED PROTEIN (Novosphingobium aromaticivorans)	4 / 7	SER A 40 ALA A 61 ALA A 62 ALA A 64	None	0.85A	3a2qA-2rfrA: undetectable	3a2qA-2rfrA: 16.70

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1JTV_A_TESA500_1","17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1","2rfr","UNCHARACTERIZED PROTEIN","Novosphingobium aromaticivorans",4,"VAL A  51;TYR A  27;HIS A  82;VAL A 104","None","1.19A","1jtvA-2rfrA:undetectable","1jtvA-2rfrA:21.45"],["2Q6F_C_010C6_0","INFECTIOUS BRONCHITIS VIRUS (IBV) MAIN PROTEASE;N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE","2rfr","UNCHARACTERIZED PROTEIN","Novosphingobium aromaticivorans",3,"ASN A 120;LEU A 151;HIS A 101","None","0.84A","2q6fB-2rfrA:undetectable","2q6fB-2rfrA:19.22"],["2QHF_A_ACTA507_0","CHORISMATE SYNTHASE","2rfr","UNCHARACTERIZED PROTEIN","Novosphingobium aromaticivorans",3,"LEU A 140;ASN A 138;ARG A 116","None","0.87A","2qhfA-2rfrA:undetectable","2qhfA-2rfrA:21.33"],["3A2Q_A_ACAA602_1","6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE","2rfr","UNCHARACTERIZED PROTEIN","Novosphingobium aromaticivorans",4,"SER A  40;ALA A  61;ALA A  62;ALA A  64","None","0.85A","3a2qA-2rfrA:undetectable","3a2qA-2rfrA:16.70"]]