SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		11 / 12 ALA A 143
TYR A 145
TYR A 171
ASP A 173
GLN A 175
GLU A 212
ASP A 214
GLU A 217
THR A 246
ARG A 251
ASP A 368
 CTR  A 431 ( 4.6A)
CTR  A 431 (-3.8A)
None
CTR  A 431 (-3.0A)
CTR  A 431 (-3.3A)
CTR  A 431 (-3.3A)
CTR  A 431 (-4.2A)
CTR  A 431 (-3.1A)
CTR  A 431 (-4.2A)
CTR  A 431 (-3.4A)
None
 0.72A 1dy4A-2rfzA:
61.9		 1dy4A-2rfzA:
50.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		4 / 5 HIS A 228
TRP A 366
ALA A 371
TRP A 375
 CTR  A 431 (-4.1A)
CTR  A 432 (-4.6A)
None
CTR  A 431 (-4.0A)
 0.44A 1dy4A-2rfzA:
61.9		 1dy4A-2rfzA:
50.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		4 / 5 TYR A 109
VAL A 288
ILE A 419
MET A 359
 None
 1.37A 1opjA-2rfzA:
undetectable		 1opjA-2rfzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		3 / 3 GLU A 217
ASN A 141
TRP A 375
 CTR  A 431 (-3.1A)
None
CTR  A 431 (-4.0A)
 0.94A 1r15C-2rfzA:
undetectable		 1r15C-2rfzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		3 / 3 GLU A 217
ASN A 141
TRP A 375
 CTR  A 431 (-3.1A)
None
CTR  A 431 (-4.0A)
 0.97A 1r15D-2rfzA:
undetectable		 1r15D-2rfzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		3 / 3 GLU A 217
ASN A 141
TRP A 375
 CTR  A 431 (-3.1A)
None
CTR  A 431 (-4.0A)
 0.95A 1r15E-2rfzA:
undetectable		 1r15E-2rfzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		3 / 3 GLU A 217
ASN A 141
TRP A 375
 CTR  A 431 (-3.1A)
None
CTR  A 431 (-4.0A)
 0.98A 1r15F-2rfzA:
undetectable		 1r15F-2rfzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 LEU A 351
ALA A 211
ASP A 257
ILE A 324
LEU A 297
 None
 1.16A 2jn3A-2rfzA:
undetectable		 2jn3A-2rfzA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 11 LEU A 127
LEU A 361
LEU A  14
VAL A  32
VAL A  28
 None
 1.32A 2po5B-2rfzA:
undetectable		 2po5B-2rfzA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		4 / 6 SER A 426
ARG A 420
ILE A 419
PHE A 120
 None
 1.21A 2qeiA-2rfzA:
undetectable		 2qeiA-2rfzA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 VAL A 183
GLY A 168
TYR A 171
ILE A  34
TRP A  38
 None
None
None
None
CTR  A 432 (-3.8A)
 1.49A 3bwmA-2rfzA:
undetectable		 3bwmA-2rfzA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 VAL A 183
GLY A 168
TYR A 171
ILE A  34
TRP A  38
 None
None
None
None
CTR  A 432 (-3.8A)
 1.49A 3bwyA-2rfzA:
undetectable		 3bwyA-2rfzA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		4 / 8 GLY A 204
ASN A 188
TRP A  55
TYR A 206
 None
 1.37A 3ccfA-2rfzA:
undetectable		 3ccfA-2rfzA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		4 / 6 GLU A 212
THR A 246
ALA A 174
ALA A 258
 CTR  A 431 (-3.3A)
CTR  A 431 (-4.2A)
None
None
 1.23A 3ns1C-2rfzA:
undetectable		 3ns1C-2rfzA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 GLY A 164
ALA A 163
GLY A 185
VAL A 183
ILE A  71
 None
PCA  A   1 ( 3.6A)
PCA  A   1 ( 2.8A)
None
None
 0.85A 3nu5A-2rfzA:
undetectable		 3nu5A-2rfzA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		4 / 7 TYR A 145
ASP A 179
ALA A 177
TYR A 171
 CTR  A 431 (-3.8A)
CTR  A 432 (-2.3A)
None
None
 1.19A 3rodD-2rfzA:
undetectable		 3rodD-2rfzA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 11 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 360
 None
 1.43A 4c5lA-2rfzA:
undetectable		 4c5lA-2rfzA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 9 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 360
 None
 1.38A 4c5lB-2rfzA:
undetectable		 4c5lB-2rfzA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 10 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 360
 None
 1.43A 4c5lC-2rfzA:
undetectable		 4c5lC-2rfzA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 10 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 360
 None
 1.39A 4c5lD-2rfzA:
undetectable		 4c5lD-2rfzA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 11 LEU A 133
VAL A 131
PHE A 301
SER A 218
PHE A 223
 None
 1.34A 4evrA-2rfzA:
undetectable		 4evrA-2rfzA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		8 / 9 ASN A 141
ALA A 143
TYR A 145
TYR A 171
ASP A 173
GLU A 212
ASP A 214
TRP A 366
 None
CTR  A 431 ( 4.6A)
CTR  A 431 (-3.8A)
None
CTR  A 431 (-3.0A)
CTR  A 431 (-3.3A)
CTR  A 431 (-4.2A)
CTR  A 432 (-4.6A)
 0.43A 4ipmA-2rfzA:
59.8		 4ipmA-2rfzA:
49.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		8 / 9 ASN A 141
TYR A 145
TYR A 171
ASP A 173
GLU A 212
ASP A 214
GLU A 217
TRP A 366
 None
CTR  A 431 (-3.8A)
None
CTR  A 431 (-3.0A)
CTR  A 431 (-3.3A)
CTR  A 431 (-4.2A)
CTR  A 431 (-3.1A)
CTR  A 432 (-4.6A)
 0.63A 4ipmA-2rfzA:
59.8		 4ipmA-2rfzA:
49.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 10 SER A 160
GLU A 151
ASP A 115
TYR A 235
GLY A 154
 PCA  A   1 ( 4.3A)
None
None
None
None
 1.38A 4qb9A-2rfzA:
0.0		 4qb9A-2rfzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		4 / 5 TYR A 171
SER A 364
ASP A 214
ASP A 262
 None
None
CTR  A 431 (-4.2A)
CTR  A 431 ( 4.5A)
 1.18A 4qtuB-2rfzA:
undetectable		 4qtuB-2rfzA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		4 / 5 GLY A 204
TYR A 370
TYR A 247
GLY A 245
 None
 1.06A 5ayfA-2rfzA:
0.0		 5ayfA-2rfzA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 ILE A 419
VAL A 288
VAL A 289
LEU A 361
THR A 427
 None
 1.19A 5bykA-2rfzA:
undetectable		 5bykA-2rfzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 GLY A 184
ASN A 188
GLY A 153
GLY A 207
SER A 208
 None
 1.14A 5hikA-2rfzA:
undetectable		 5hikA-2rfzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 VAL A 183
GLY A 168
TYR A 171
ILE A  34
TRP A  38
 None
None
None
None
CTR  A 432 (-3.8A)
 1.48A 5lsaA-2rfzA:
undetectable		 5lsaA-2rfzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		4 / 7 GLU A  31
ALA A 165
GLY A 168
TYR A 167
 None
 1.07A 5uxdA-2rfzA:
undetectable		 5uxdA-2rfzA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 VAL A 147
GLU A 212
LEU A  90
LEU A  14
LEU A  92
 None
CTR  A 431 (-3.3A)
None
None
None
 1.08A 6ew0B-2rfzA:
undetectable		 6ew0B-2rfzA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 VAL A 147
GLU A 212
LEU A  90
LEU A  14
LEU A  92
 None
CTR  A 431 (-3.3A)
None
None
None
 1.08A 6ew0D-2rfzA:
undetectable		 6ew0D-2rfzA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 VAL A 147
GLU A 212
LEU A  90
LEU A  14
LEU A  92
 None
CTR  A 431 (-3.3A)
None
None
None
 1.08A 6ew0H-2rfzA:
undetectable		 6ew0H-2rfzA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 VAL A 147
GLU A 212
LEU A  90
LEU A  14
LEU A  92
 None
CTR  A 431 (-3.3A)
None
None
None
 1.08A 6ew0I-2rfzA:
undetectable		 6ew0I-2rfzA:
12.53