SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rg2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		5 / 10 MET A  57
ALA A  79
LEU A  81
LEU A 142
ILE A  22
 None
None
CSO  A   2 ( 4.0A)
EDO  A 333 ( 4.5A)
None
 1.27A 1a52B-2rg2A:
undetectable		 1a52B-2rg2A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		5 / 9 MET A  57
ALA A  79
LEU A  81
LEU A 142
ILE A  22
 None
None
CSO  A   2 ( 4.0A)
EDO  A 333 ( 4.5A)
None
 1.29A 1ereA-2rg2A:
undetectable		 1ereA-2rg2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		5 / 9 MET A  57
ALA A  79
LEU A  81
LEU A 142
ILE A  22
 None
None
CSO  A   2 ( 4.0A)
EDO  A 333 ( 4.5A)
None
 1.30A 1ereB-2rg2A:
undetectable		 1ereB-2rg2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		5 / 9 MET A  57
ALA A  79
LEU A  81
LEU A 142
ILE A  22
 None
None
CSO  A   2 ( 4.0A)
EDO  A 333 ( 4.5A)
None
 1.31A 1ereD-2rg2A:
undetectable		 1ereD-2rg2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		4 / 5 TYR A  52
GLU A  73
PHE A  32
PRO A  34
 None
 1.16A 1mclA-2rg2A:
0.0
1mclB-2rg2A:
0.0
1mclP-2rg2A:
undetectable		 1mclA-2rg2A:
20.42
1mclB-2rg2A:
20.42
1mclP-2rg2A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		5 / 9 ILE A  33
PHE A  67
GLY A  56
TYR A 317
GLU A 307
 None
 1.31A 1mrgA-2rg2A:
undetectable		 1mrgA-2rg2A:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		7 / 12 MET A  20
PHE A  26
ALA A  68
ASN A  82
ILE A 137
THR A 140
LEU A 142
 EDO  A 333 (-3.8A)
EDO  A 334 (-4.2A)
EDO  A 333 ( 3.7A)
GOL  A 336 (-3.7A)
None
None
EDO  A 333 ( 4.5A)
 1.03A 2bjfA-2rg2A:
53.1		 2bjfA-2rg2A:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		7 / 12 MET A  20
TYR A  24
ASN A  82
ILE A 133
ILE A 137
THR A 140
LEU A 142
 EDO  A 333 (-3.8A)
None
GOL  A 336 (-3.7A)
None
None
None
EDO  A 333 ( 4.5A)
 1.13A 2bjfA-2rg2A:
53.1		 2bjfA-2rg2A:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		8 / 12 MET A  20
TYR A  24
PHE A  26
ALA A  68
ASN A  82
ILE A 133
THR A 140
LEU A 142
 EDO  A 333 (-3.8A)
None
EDO  A 334 (-4.2A)
EDO  A 333 ( 3.7A)
GOL  A 336 (-3.7A)
None
None
EDO  A 333 ( 4.5A)
 0.67A 2bjfA-2rg2A:
53.1		 2bjfA-2rg2A:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		7 / 12 TYR A  24
PHE A  61
ASN A  82
ILE A 133
ILE A 137
THR A 140
LEU A 142
 None
None
GOL  A 336 (-3.7A)
None
None
None
EDO  A 333 ( 4.5A)
 1.32A 2bjfA-2rg2A:
53.1		 2bjfA-2rg2A:
99.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		3 / 3 ARG A 231
ASN A 297
THR A 276
 None
 0.83A 2q63A-2rg2A:
undetectable		 2q63A-2rg2A:
14.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		7 / 12 ILE A  22
PHE A  26
ALA A  68
ASN A  82
ILE A 137
THR A 140
LEU A 142
 None
EDO  A 334 (-4.2A)
EDO  A 333 ( 3.7A)
GOL  A 336 (-3.7A)
None
None
EDO  A 333 ( 4.5A)
 1.05A 2rlcA-2rg2A:
53.5		 2rlcA-2rg2A:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		9 / 12 ILE A  22
PHE A  26
THR A  66
ALA A  68
ASN A  82
ILE A 133
ASN A 139
THR A 140
LEU A 142
 None
EDO  A 334 (-4.2A)
EDO  A 334 (-3.4A)
EDO  A 333 ( 3.7A)
GOL  A 336 (-3.7A)
None
None
None
EDO  A 333 ( 4.5A)
 0.45A 2rlcA-2rg2A:
53.5		 2rlcA-2rg2A:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		8 / 12 ILE A  22
THR A  66
ASN A  82
ILE A 133
ILE A 137
ASN A 139
THR A 140
LEU A 142
 None
EDO  A 334 (-3.4A)
GOL  A 336 (-3.7A)
None
None
None
None
EDO  A 333 ( 4.5A)
 0.84A 2rlcA-2rg2A:
53.5		 2rlcA-2rg2A:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		6 / 12 PHE A  61
ASN A  82
ILE A 133
ILE A 137
ASN A 139
THR A 140
 None
GOL  A 336 (-3.7A)
None
None
None
None
 0.96A 2rlcA-2rg2A:
53.5		 2rlcA-2rg2A:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		3 / 3 ASN A  82
ASN A 175
ARG A 228
 GOL  A 336 (-3.7A)
CSO  A   2 (-3.1A)
CSO  A   2 ( 3.4A)
 0.13A 2rlcA-2rg2A:
53.5		 2rlcA-2rg2A:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z71_A_PNVA903_1
(PENICILLIN ACYLASE)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		5 / 10 ASN A 175
PRO A 225
ARG A 228
GLU A 270
ASP A 274
 CSO  A   2 (-3.1A)
GOL  A 336 ( 4.6A)
CSO  A   2 ( 3.4A)
None
GOL  A 336 ( 4.4A)
 0.63A 2z71A-2rg2A:
41.9
2z71C-2rg2A:
42.3		 2z71A-2rg2A:
36.18
2z71C-2rg2A:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z71_C_PNVC904_1
(PENICILLIN ACYLASE)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		6 / 10 ASN A 175
ARG A 228
THR A 268
GLU A 270
LYS A 272
ASP A 274
 CSO  A   2 (-3.1A)
CSO  A   2 ( 3.4A)
None
None
None
GOL  A 336 ( 4.4A)
 0.77A 2z71A-2rg2A:
42.0
2z71C-2rg2A:
42.5		 2z71A-2rg2A:
36.18
2z71C-2rg2A:
36.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		5 / 12 PHE A 229
GLY A   4
THR A   3
THR A 174
LEU A  15
 None
None
CSO  A   2 ( 3.8A)
CSO  A   2 ( 4.3A)
None
 1.24A 2zifA-2rg2A:
undetectable		 2zifA-2rg2A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		3 / 3 LYS A 120
LYS A 152
VAL A 116
 None
 1.08A 3brfA-2rg2A:
undetectable		 3brfA-2rg2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		4 / 7 THR A  59
THR A  66
ILE A 133
ILE A 137
 EDO  A 335 ( 3.7A)
EDO  A 334 (-3.4A)
None
None
 0.79A 3deuA-2rg2A:
undetectable		 3deuA-2rg2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		4 / 4 VAL A 119
PHE A 105
PHE A  67
VAL A  54
 None
 1.33A 3rv5C-2rg2A:
0.4
3rv5D-2rg2A:
0.4		 3rv5C-2rg2A:
14.75
3rv5D-2rg2A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		4 / 7 PRO A  34
VAL A  54
LEU A 107
ILE A 314
 None
 0.92A 3u5kB-2rg2A:
undetectable		 3u5kB-2rg2A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		5 / 12 ILE A 149
ILE A 255
LEU A 256
GLY A 171
SER A 153
 None
None
None
EDO  A 331 (-3.2A)
EDO  A 331 (-2.7A)
 1.17A 4o1eB-2rg2A:
undetectable		 4o1eB-2rg2A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		5 / 11 ASP A  69
ALA A 260
TYR A 278
GLY A   4
SER A 280
 None
 1.27A 4xnxA-2rg2A:
undetectable		 4xnxA-2rg2A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		5 / 9 ILE A  33
PHE A  67
GLY A  56
TYR A 317
GLU A 307
 None
 1.24A 4yp2B-2rg2A:
undetectable		 4yp2B-2rg2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		5 / 9 ILE A  33
PHE A  67
GLY A  56
TYR A 317
GLU A 307
 None
 1.26A 5cf9B-2rg2A:
undetectable		 5cf9B-2rg2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		5 / 12 SER A 280
ILE A 255
HIS A  14
VAL A 172
VAL A 232
 None
 1.15A 5dpdA-2rg2A:
undetectable		 5dpdA-2rg2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		4 / 4 ALA A 226
PRO A  84
LEU A 142
HIS A 143
 None
GOL  A 336 (-4.2A)
EDO  A 333 ( 4.5A)
None
 1.47A 5eskA-2rg2A:
undetectable		 5eskA-2rg2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		5 / 12 ASP A 274
MET A  20
ASN A  19
LEU A  18
ALA A  79
 GOL  A 336 ( 4.4A)
EDO  A 333 (-3.8A)
None
None
None
 1.19A 5kbwA-2rg2A:
undetectable		 5kbwA-2rg2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		3 / 3 GLY A  96
THR A  98
ASN A 125
 None
 0.65A 5odiG-2rg2A:
undetectable		 5odiG-2rg2A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 2rg2 CHOLOYLGLYCINE
HYDROLASE
(Clostridium
perfringens) 		4 / 8 ILE A 230
VAL A 172
ILE A 255
ALA A 238
 None
 0.72A 5og9A-2rg2A:
undetectable		 5og9A-2rg2A:
20.70