SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rg4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2rg4 UNCHARACTERIZED
PROTEIN
(Oceanicola
granulosus) 		4 / 8 VAL A 175
GLY A 176
THR A 130
ILE A 199
 None
 0.62A 2a1mB-2rg4A:
undetectable		 2a1mB-2rg4A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2rg4 UNCHARACTERIZED
PROTEIN
(Oceanicola
granulosus) 		4 / 5 ASN A 192
ALA A 194
PRO A 135
ALA A 140
 None
 1.36A 3twpD-2rg4A:
undetectable		 3twpD-2rg4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 2rg4 UNCHARACTERIZED
PROTEIN
(Oceanicola
granulosus) 		5 / 11 LEU A  76
LEU A  19
VAL A  84
HIS A  83
LEU A 180
 None
 0.97A 4p65C-2rg4A:
undetectable
4p65D-2rg4A:
undetectable
4p65J-2rg4A:
undetectable
4p65L-2rg4A:
undetectable		 4p65C-2rg4A:
7.57
4p65D-2rg4A:
10.98
4p65J-2rg4A:
10.98
4p65L-2rg4A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 2rg4 UNCHARACTERIZED
PROTEIN
(Oceanicola
granulosus) 		5 / 12 CYH A  35
LEU A  80
LEU A  66
LEU A  63
ALA A  39
 None
 1.32A 4rtbA-2rg4A:
undetectable		 4rtbA-2rg4A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 2rg4 UNCHARACTERIZED
PROTEIN
(Oceanicola
granulosus) 		4 / 7 LEU A  63
SER A  59
ILE A 107
VAL A 201
 None
 1.17A 4tvtA-2rg4A:
undetectable		 4tvtA-2rg4A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2rg4 UNCHARACTERIZED
PROTEIN
(Oceanicola
granulosus) 		5 / 12 ASP A 104
ASN A 204
HIS A 121
HIS A 187
HIS A 119
 None
None
FE  A 217 (-3.4A)
FE  A 217 (-3.4A)
FE  A 217 (-3.1A)
 1.39A 4yhaA-2rg4A:
undetectable		 4yhaA-2rg4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2rg4 UNCHARACTERIZED
PROTEIN
(Oceanicola
granulosus) 		5 / 11 ASP A 104
ASN A 204
HIS A 121
HIS A 187
HIS A 119
 None
None
FE  A 217 (-3.4A)
FE  A 217 (-3.4A)
FE  A 217 (-3.1A)
 1.42A 4yhaC-2rg4A:
undetectable		 4yhaC-2rg4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2rg4 UNCHARACTERIZED
PROTEIN
(Oceanicola
granulosus) 		5 / 12 PHE A 203
SER A  79
LEU A  26
LEU A 180
TYR A  15
 None
 1.49A 5ji0D-2rg4A:
undetectable		 5ji0D-2rg4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2rg4 UNCHARACTERIZED
PROTEIN
(Oceanicola
granulosus) 		5 / 12 PHE A 203
SER A  79
ILE A  72
LEU A 180
TYR A  15
 None
 1.32A 5ycpA-2rg4A:
undetectable		 5ycpA-2rg4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2rg4 UNCHARACTERIZED
PROTEIN
(Oceanicola
granulosus) 		5 / 12 PHE A 203
SER A  79
LEU A  26
LEU A 180
TYR A  15
 None
 1.42A 5ycpA-2rg4A:
undetectable		 5ycpA-2rg4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 2rg4 UNCHARACTERIZED
PROTEIN
(Oceanicola
granulosus) 		3 / 3 HIS A 119
HIS A 187
HIS A 121
 FE  A 217 (-3.1A)
FE  A 217 (-3.4A)
FE  A 217 (-3.4A)
 0.58A 5zrdA-2rg4A:
undetectable		 5zrdA-2rg4A:
17.85