SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rgh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 9 GLU A 110
ILE A 106
PRO A 105
ALA A 163
THR A 113
 None
 0.93A 1aj6A-2rghA:
undetectable		 1aj6A-2rghA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 11 ILE A  96
GLY A 505
PHE A 471
ASN A 470
ASP A 179
 None
 1.37A 1ho5A-2rghA:
undetectable		 1ho5A-2rghA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		4 / 6 TYR A 504
GLU A 291
TYR A 547
GLY A 535
 None
 0.59A 1maaB-2rghA:
undetectable
1maaD-2rghA:
undetectable		 1maaB-2rghA:
23.02
1maaD-2rghA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 12 LEU A 492
ASP A 496
ILE A 500
ARG A 531
HIS A 554
 None
 1.40A 1tmxB-2rghA:
undetectable		 1tmxB-2rghA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		3 / 3 LYS A 279
ASP A 337
ASP A 322
 None
 0.89A 2br4D-2rghA:
2.1		 2br4D-2rghA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		4 / 6 ASP A 571
TYR A 547
PHE A 577
LEU A 536
 None
 1.14A 2w98A-2rghA:
undetectable
2w98B-2rghA:
undetectable		 2w98A-2rghA:
20.07
2w98B-2rghA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 10 VAL A 569
ILE A 573
LEU A 514
LEU A 536
GLY A 535
 None
 1.25A 2xf3A-2rghA:
undetectable		 2xf3A-2rghA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		3 / 3 PRO A 544
LEU A 548
ARG A 559
 None
 0.42A 3aqiA-2rghA:
undetectable		 3aqiA-2rghA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		3 / 3 PRO A 544
LEU A 548
ARG A 559
 None
 0.49A 3aqiB-2rghA:
undetectable		 3aqiB-2rghA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 12 VAL A  33
ALA A 437
ALA A  39
ILE A  28
THR A 231
 None
None
None
FAD  A 609 (-4.8A)
None
 1.22A 3dl9B-2rghA:
undetectable		 3dl9B-2rghA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		4 / 8 ASP A  51
GLY A  27
ILE A  28
PRO A 347
 None
FAD  A 609 (-3.3A)
FAD  A 609 (-4.8A)
FAD  A 609 (-4.5A)
 0.83A 3el9A-2rghA:
undetectable		 3el9A-2rghA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 12 THR A  44
LEU A  21
LEU A 176
ILE A 229
ILE A 430
 None
None
None
None
FAD  A 609 (-3.5A)
 0.95A 3frqB-2rghA:
undetectable		 3frqB-2rghA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		3 / 3 ARG A 170
THR A 298
THR A 431
 None
FAD  A 609 (-3.9A)
FAD  A 609 (-4.3A)
 0.69A 3k2hB-2rghA:
undetectable		 3k2hB-2rghA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		3 / 3 ARG A 253
THR A 424
THR A  56
 None
None
FAD  A 609 (-3.9A)
 0.76A 3k2hB-2rghA:
undetectable		 3k2hB-2rghA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 12 PHE A   2
PHE A  52
ALA A 184
ILE A  23
ILE A  24
 None
None
None
None
FAD  A 609 ( 4.9A)
 1.12A 3ld6A-2rghA:
undetectable		 3ld6A-2rghA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 9 MET A  14
LEU A  21
ALA A 225
LEU A 227
VAL A 210
 None
 1.26A 3ozkA-2rghA:
undetectable		 3ozkA-2rghA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 11 ALA A 131
TYR A 274
GLY A  66
THR A 431
VAL A  89
 None
None
None
FAD  A 609 (-4.3A)
None
 1.11A 3rukD-2rghA:
undetectable		 3rukD-2rghA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		3 / 3 ASN A 553
GLU A 291
ARG A 290
 None
 1.09A 3wxoA-2rghA:
undetectable		 3wxoA-2rghA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		4 / 7 ASN A   4
LEU A 536
ARG A 533
GLY A 578
 None
 0.98A 4cp3A-2rghA:
undetectable
4cp3B-2rghA:
undetectable		 4cp3A-2rghA:
12.68
4cp3B-2rghA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 12 GLU A 158
GLU A 108
GLY A 278
LEU A 155
ILE A 324
 None
 1.03A 4hytA-2rghA:
undetectable		 4hytA-2rghA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 12 GLU A 158
GLU A 108
GLY A 278
LEU A 155
ILE A 324
 None
 1.03A 4hytC-2rghA:
undetectable		 4hytC-2rghA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 8 MET A  14
LEU A  21
ALA A 225
LEU A 227
VAL A 210
 None
 1.11A 4iizB-2rghA:
undetectable		 4iizB-2rghA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		4 / 6 ASP A 316
ALA A 343
THR A 299
THR A 298
 None
None
None
FAD  A 609 (-3.9A)
 1.50A 4w5rA-2rghA:
undetectable		 4w5rA-2rghA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		4 / 4 ILE A 511
ARG A 175
TYR A 534
GLU A 539
 None
 1.50A 4zzbD-2rghA:
undetectable		 4zzbD-2rghA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		3 / 3 THR A 299
THR A 298
PHE A 296
 None
FAD  A 609 (-3.9A)
None
 0.78A 5cxvA-2rghA:
undetectable		 5cxvA-2rghA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 12 GLY A 233
GLY A 428
ASP A 432
GLY A  55
SER A  57
 FAD  A 609 (-3.4A)
None
None
FAD  A 609 (-3.6A)
FAD  A 609 (-2.6A)
 1.24A 5hikA-2rghA:
undetectable		 5hikA-2rghA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		3 / 3 HIS A 259
SER A  60
ARG A 346
 FAD  A 609 (-4.6A)
FAD  A 609 (-4.2A)
FAD  A 609 (-4.4A)
 1.00A 5u63A-2rghA:
4.4		 5u63A-2rghA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		3 / 3 GLY A 468
ASN A 507
ARG A 175
 None
 0.69A 5w7bD-2rghA:
undetectable		 5w7bD-2rghA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		4 / 6 TYR A 107
LEU A 143
GLU A 152
LEU A 103
 None
 1.18A 5xooA-2rghA:
undetectable		 5xooA-2rghA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		4 / 6 GLN A 465
VAL A  35
ARG A  86
PRO A  97
 None
 1.19A 6brdB-2rghA:
undetectable		 6brdB-2rghA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 10 LEU A 143
ALA A 163
LEU A 103
MET A 102
ILE A  68
 None
 1.35A 6cbzB-2rghA:
undetectable		 6cbzB-2rghA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		4 / 8 ASP A 187
TYR A 464
GLY A  91
ASN A 180
 None
 0.85A 6giqL-2rghA:
undetectable
6giqP-2rghA:
undetectable
6giqT-2rghA:
undetectable		 6giqL-2rghA:
21.42
6giqP-2rghA:
15.71
6giqT-2rghA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 12 GLY A  26
GLY A  25
VAL A 239
ASN A 230
GLY A 233
 FAD  A 609 ( 4.9A)
FAD  A 609 (-3.1A)
None
None
FAD  A 609 (-3.4A)
 1.00A 6gneA-2rghA:
2.8		 6gneA-2rghA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		5 / 12 GLY A  26
GLY A  25
VAL A 239
ASN A 230
GLY A 233
 FAD  A 609 ( 4.9A)
FAD  A 609 (-3.1A)
None
None
FAD  A 609 (-3.4A)
 1.01A 6gneB-2rghA:
2.8		 6gneB-2rghA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		4 / 8 ASP A 168
ILE A  68
ARG A  86
TYR A 141
 None
 1.22A 6hisA-2rghA:
2.5
6hisB-2rghA:
2.5		 6hisA-2rghA:
9.39
6hisB-2rghA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		4 / 8 ASP A 168
ILE A  68
ARG A  86
TYR A 141
 None
 1.23A 6hisB-2rghA:
2.5
6hisC-2rghA:
2.4		 6hisB-2rghA:
9.39
6hisC-2rghA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		4 / 8 ASP A 168
ILE A  68
ARG A  86
TYR A 141
 None
 1.23A 6hisC-2rghA:
2.4
6hisD-2rghA:
2.4		 6hisC-2rghA:
9.39
6hisD-2rghA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		4 / 8 ASP A 168
ILE A  68
ARG A  86
TYR A 141
 None
 1.23A 6hisD-2rghA:
2.4
6hisE-2rghA:
2.4		 6hisD-2rghA:
9.39
6hisE-2rghA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE
(Streptococcus
sp.) 		4 / 8 TYR A 141
ASP A 168
ILE A  68
ARG A  86
 None
 1.24A 6hisA-2rghA:
2.5
6hisE-2rghA:
2.4		 6hisA-2rghA:
9.39
6hisE-2rghA:
9.39