SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rgj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 175
ALA A 311
ASP A 310
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
FAD  A 403 (-3.2A)
None
 0.97A 1d4yA-2rgjA:
undetectable		 1d4yA-2rgjA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A 128
LEU A  34
GLY A  11
LEU A  17
 None
None
FAD  A 403 (-3.2A)
None
 0.86A 1gtiA-2rgjA:
undetectable		 1gtiA-2rgjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A 128
LEU A  34
GLY A  11
LEU A  17
 None
None
FAD  A 403 (-3.2A)
None
 0.90A 1gtiB-2rgjA:
undetectable		 1gtiB-2rgjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A 128
LEU A  34
GLY A  11
LEU A  17
 None
None
FAD  A 403 (-3.2A)
None
 0.77A 1gtiE-2rgjA:
undetectable		 1gtiE-2rgjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 125
GLY A  29
LEU A  21
ALA A  22
LEU A  33
 None
 1.05A 1jipA-2rgjA:
undetectable		 1jipA-2rgjA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 175
ALA A 311
ASP A 310
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
FAD  A 403 (-3.2A)
None
 0.99A 1t3rA-2rgjA:
undetectable		 1t3rA-2rgjA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 175
ALA A 311
ASP A 310
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
FAD  A 403 (-3.2A)
None
 1.02A 1t7iA-2rgjA:
undetectable		 1t7iA-2rgjA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 121
LEU A  17
SER A  18
LEU A  60
 None
 0.94A 1ya3A-2rgjA:
undetectable		 1ya3A-2rgjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 300
GLU A 351
TYR A 350
 None
 0.96A 2a3aA-2rgjA:
undetectable		 2a3aA-2rgjA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 156
GLY A 163
ALA A 146
ILE A 144
 None
 0.75A 2aohB-2rgjA:
undetectable		 2aohB-2rgjA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 282
THR A 194
VAL A 193
LEU A 232
 None
 1.06A 2e1qA-2rgjA:
undetectable		 2e1qA-2rgjA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 282
THR A 194
VAL A 193
LEU A 232
 None
 1.01A 2e1qC-2rgjA:
undetectable		 2e1qC-2rgjA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 191
GLY A 322
ALA A 323
GLY A  13
ILE A  47
 FAD  A 403 (-3.3A)
FAD  A 403 (-3.9A)
FAD  A 403 (-3.2A)
FAD  A 403 (-3.3A)
FAD  A 403 (-4.7A)
 0.80A 2hs1A-2rgjA:
undetectable		 2hs1A-2rgjA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 191
GLY A 322
ALA A 323
GLY A  13
ILE A  47
 FAD  A 403 (-3.3A)
FAD  A 403 (-3.9A)
FAD  A 403 (-3.2A)
FAD  A 403 (-3.3A)
FAD  A 403 (-4.7A)
 0.89A 2ienA-2rgjA:
undetectable		 2ienA-2rgjA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 4 ASP A   6
LEU A 156
GLY A 157
ARG A 127
 None
 1.36A 2j2pD-2rgjA:
0.0
2j2pE-2rgjA:
0.0		 2j2pD-2rgjA:
19.18
2j2pE-2rgjA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		6 / 12 LEU A 328
GLY A 322
ALA A 323
ILE A 104
ALA A  56
ILE A 327
 None
FAD  A 403 (-3.9A)
FAD  A 403 (-3.2A)
None
None
None
 1.33A 2nmzA-2rgjA:
undetectable		 2nmzA-2rgjA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		6 / 12 LEU A 328
GLY A 322
ALA A 323
ILE A 104
ALA A  56
ILE A 327
 None
FAD  A 403 (-3.9A)
FAD  A 403 (-3.2A)
None
None
None
 1.40A 2nmzB-2rgjA:
undetectable		 2nmzB-2rgjA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLN A  50
ALA A  56
GLY A  15
LEU A  17
LEU A 328
 None
None
FAD  A 403 (-3.3A)
None
None
 1.24A 2nv4A-2rgjA:
undetectable		 2nv4A-2rgjA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 175
ALA A 311
ASP A 310
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
FAD  A 403 (-3.2A)
None
 1.10A 2o4pA-2rgjA:
undetectable		 2o4pA-2rgjA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 326
ASP A 329
GLY A 166
ILE A 167
ILE A  14
 FAD  A 403 ( 3.8A)
None
FAD  A 403 (-3.6A)
None
FAD  A 403 (-3.5A)
 1.05A 2qhcA-2rgjA:
undetectable		 2qhcA-2rgjA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 307
ASP A 165
ALA A 311
ILE A 305
 None
FAD  A 403 (-4.8A)
None
None
 0.93A 2qhfA-2rgjA:
undetectable		 2qhfA-2rgjA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 175
ALA A 311
ASP A 310
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
FAD  A 403 (-3.2A)
None
 0.92A 2rkfA-2rgjA:
undetectable		 2rkfA-2rgjA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A  38
HIS A 168
ASP A 310
 None
None
FAD  A 403 (-2.7A)
 0.72A 2wa2B-2rgjA:
3.6		 2wa2B-2rgjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 282
THR A 194
VAL A 193
LEU A 232
 None
 0.95A 3ax7A-2rgjA:
undetectable		 3ax7A-2rgjA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 330
LEU A 337
ILE A 327
SER A  18
LEU A 308
 None
 1.34A 3cjtK-2rgjA:
3.9		 3cjtK-2rgjA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 191
GLY A 322
ALA A 323
GLY A  13
ILE A  47
 FAD  A 403 (-3.3A)
FAD  A 403 (-3.9A)
FAD  A 403 (-3.2A)
FAD  A 403 (-3.3A)
FAD  A 403 (-4.7A)
 0.82A 3d20A-2rgjA:
undetectable		 3d20A-2rgjA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 175
ALA A 311
ASP A 310
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
FAD  A 403 (-3.2A)
None
 0.99A 3ektA-2rgjA:
undetectable		 3ektA-2rgjA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 175
ALA A 311
ASP A 310
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
FAD  A 403 (-3.2A)
None
 1.02A 3gguB-2rgjA:
undetectable		 3gguB-2rgjA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 255
ASP A 261
ASP A 248
 None
 0.67A 3jayA-2rgjA:
undetectable		 3jayA-2rgjA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 255
ASP A 261
ASP A 248
 None
 0.69A 3jb2A-2rgjA:
undetectable		 3jb2A-2rgjA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 255
ASP A 261
ASP A 248
 None
 0.62A 3jb3A-2rgjA:
undetectable		 3jb3A-2rgjA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 7 SER A 241
VAL A 239
VAL A 244
LEU A 247
 None
 0.80A 3o14A-2rgjA:
undetectable		 3o14A-2rgjA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A 175
ALA A 311
ASP A 310
ILE A 167
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
None
FAD  A 403 (-3.2A)
None
 1.12A 3ogqA-2rgjA:
undetectable		 3ogqA-2rgjA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 175
ALA A 311
ASP A 310
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
FAD  A 403 (-3.2A)
None
 0.99A 3oy4B-2rgjA:
undetectable		 3oy4B-2rgjA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 191
GLY A 322
ALA A 323
GLY A  13
ILE A  47
 FAD  A 403 (-3.3A)
FAD  A 403 (-3.9A)
FAD  A 403 (-3.2A)
FAD  A 403 (-3.3A)
FAD  A 403 (-4.7A)
 0.91A 3s54A-2rgjA:
undetectable		 3s54A-2rgjA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  63
ALA A  58
SER A  18
HIS A  24
GLU A 119
 None
 1.32A 3s8pA-2rgjA:
undetectable		 3s8pA-2rgjA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  63
ALA A  58
SER A  18
HIS A  24
GLU A 119
 None
 1.31A 3s8pB-2rgjA:
0.0		 3s8pB-2rgjA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 175
ALA A 311
ASP A 310
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
FAD  A 403 (-3.2A)
None
 0.97A 3spkA-2rgjA:
undetectable		 3spkA-2rgjA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 175
ALA A 311
ASP A 310
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
FAD  A 403 (-3.2A)
None
 0.96A 3spkB-2rgjA:
undetectable		 3spkB-2rgjA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 282
THR A 194
VAL A 193
LEU A 232
 None
 1.01A 3uniA-2rgjA:
undetectable		 3uniA-2rgjA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 175
ALA A 311
ASP A 310
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
FAD  A 403 (-3.2A)
None
 1.01A 4dqcB-2rgjA:
undetectable		 4dqcB-2rgjA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 352
GLU A 349
TYR A 350
GLY A 301
 None
 1.01A 4fgzA-2rgjA:
undetectable		 4fgzA-2rgjA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  16
ASP A 329
ILE A   7
VAL A 162
LEU A 161
 None
 1.04A 4fr0A-2rgjA:
undetectable		 4fr0A-2rgjA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  68
GLY A  63
PRO A  64
LEU A  60
ILE A 327
 None
 0.99A 4n49A-2rgjA:
undetectable		 4n49A-2rgjA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 175
ALA A 311
ASP A 310
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
FAD  A 403 (-3.2A)
None
 1.03A 4njtB-2rgjA:
undetectable		 4njtB-2rgjA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 10 HIS A  24
LEU A  23
ALA A  22
LEU A 121
LEU A  60
 None
 1.24A 4p65A-2rgjA:
undetectable
4p65B-2rgjA:
undetectable
4p65F-2rgjA:
undetectable
4p65H-2rgjA:
undetectable		 4p65A-2rgjA:
3.91
4p65B-2rgjA:
4.99
4p65F-2rgjA:
4.99
4p65H-2rgjA:
4.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 175
ALA A 311
ASP A 310
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
FAD  A 403 (-3.2A)
None
 1.01A 4q1wA-2rgjA:
undetectable		 4q1wA-2rgjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 317
MET A 318
TYR A 316
 None
 1.09A 4qa0B-2rgjA:
undetectable		 4qa0B-2rgjA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 317
MET A 318
TYR A 316
 None
 1.05A 4qa0A-2rgjA:
undetectable		 4qa0A-2rgjA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 317
MET A 318
TYR A 316
 None
 1.01A 4qa2B-2rgjA:
undetectable		 4qa2B-2rgjA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 6 SER A  37
GLY A 309
ASP A 310
GLY A  15
 FAD  A 403 ( 4.0A)
FAD  A 403 (-3.3A)
FAD  A 403 (-2.7A)
FAD  A 403 (-3.3A)
 0.98A 5cdpA-2rgjA:
undetectable
5cdpB-2rgjA:
undetectable		 5cdpA-2rgjA:
21.86
5cdpB-2rgjA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  63
ALA A  58
SER A  18
HIS A  24
GLU A 119
 None
 1.42A 5cprB-2rgjA:
undetectable		 5cprB-2rgjA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  16
LEU A 308
GLN A  50
GLY A 330
LEU A  17
 None
 0.88A 5hg0A-2rgjA:
undetectable		 5hg0A-2rgjA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A  59
LEU A 113
LEU A  62
LEU A  66
ILE A  49
 None
 1.20A 5v0vA-2rgjA:
undetectable		 5v0vA-2rgjA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  63
ALA A  58
SER A  18
HIS A  24
GLU A 119
 None
 1.35A 5wbvA-2rgjA:
undetectable		 5wbvA-2rgjA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  63
ALA A  58
SER A  18
HIS A  24
GLU A 119
 None
 1.33A 5wbvB-2rgjA:
undetectable		 5wbvB-2rgjA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 327
ASP A 310
GLY A 322
THR A 357
ALA A 164
 None
FAD  A 403 (-2.7A)
FAD  A 403 (-3.9A)
None
None
 1.20A 5x5qB-2rgjA:
undetectable		 5x5qB-2rgjA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 2rgj FLAVIN-CONTAINING
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A  31
LEU A 308
GLY A  27
GLY A 330
 None
 0.75A 6eu9D-2rgjA:
undetectable		 6eu9D-2rgjA:
12.69