SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rgn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25
(Homo
sapiens) 		5 / 12 ILE B 458
ALA B 456
PHE B 361
ILE B 388
LEU B 432
 None
 1.22A 1dlsA-2rgnB:
undetectable		 1dlsA-2rgnB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25
(Homo
sapiens) 		4 / 6 ASN B 422
ASP B 426
PRO B 451
SER B 454
 None
 0.90A 1n4fA-2rgnB:
undetectable		 1n4fA-2rgnB:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25
(Homo
sapiens) 		4 / 4 LEU B 222
LEU B 168
SER B 166
LEU B 229
 None
 1.06A 1ya3A-2rgnB:
undetectable		 1ya3A-2rgnB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25
(Homo
sapiens) 		4 / 8 TYR B 298
GLU B 172
TYR B 249
LEU B 246
 None
 0.84A 3rqwC-2rgnB:
3.1
3rqwD-2rgnB:
3.1		 3rqwC-2rgnB:
20.78
3rqwD-2rgnB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25
(Homo
sapiens) 		4 / 8 GLU B 172
TYR B 249
LEU B 246
TYR B 298
 None
 0.86A 3rqwF-2rgnB:
2.1
3rqwJ-2rgnB:
undetectable		 3rqwF-2rgnB:
20.78
3rqwJ-2rgnB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25
(Homo
sapiens) 		5 / 9 LEU B 302
LYS B 303
VAL B 164
TYR B 298
LEU B 235
 None
 1.50A 4b3oA-2rgnB:
undetectable		 4b3oA-2rgnB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25
(Homo
sapiens) 		4 / 6 LEU B 179
PRO B 291
GLU B 172
TYR B 175
 None
 1.22A 4z4gA-2rgnB:
undetectable		 4z4gA-2rgnB:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25
(Homo
sapiens) 		3 / 3 VAL B 292
GLN B 254
CYH B 333
 None
 0.79A 5icxC-2rgnB:
undetectable
5icxF-2rgnB:
undetectable		 5icxC-2rgnB:
21.69
5icxF-2rgnB:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25
(Homo
sapiens) 		4 / 5 CYH B 428
GLN B 455
PRO B 451
ILE B 453
 None
 1.31A 5ki6A-2rgnB:
undetectable		 5ki6A-2rgnB:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25
(Homo
sapiens) 		5 / 12 ALA B 191
PHE B 207
LEU B 287
LEU B 288
VAL B 206
 None
 1.06A 5tudA-2rgnB:
3.2		 5tudA-2rgnB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25
(Homo
sapiens) 		3 / 3 GLU B 224
TRP B 234
HIS B 242
 None
 1.08A 5xipA-2rgnB:
undetectable		 5xipA-2rgnB:
21.84