SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rgt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 2rgt FUSION OF
LIM/HOMEOBOX PROTEIN
LHX3, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-1
(Mus
musculus;
synthetic
construct) 		4 / 6 ARG A 141
LEU A 136
MET A 137
ASP A 139
 None
 0.99A 4cevA-2rgtA:
undetectable
4cevB-2rgtA:
undetectable		 4cevA-2rgtA:
18.51
4cevB-2rgtA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 2rgt FUSION OF
LIM/HOMEOBOX PROTEIN
LHX3, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-1
(Mus
musculus;
synthetic
construct) 		4 / 6 MET A 137
ASP A 139
ARG A 141
LEU A 136
 None
 0.99A 4cevA-2rgtA:
undetectable
4cevC-2rgtA:
undetectable		 4cevA-2rgtA:
18.51
4cevC-2rgtA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 2rgt FUSION OF
LIM/HOMEOBOX PROTEIN
LHX3, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-1
(Mus
musculus;
synthetic
construct) 		4 / 6 ARG A 141
LEU A 136
MET A 137
ASP A 139
 None
 0.99A 4cevD-2rgtA:
undetectable
4cevE-2rgtA:
undetectable		 4cevD-2rgtA:
18.51
4cevE-2rgtA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 2rgt FUSION OF
LIM/HOMEOBOX PROTEIN
LHX3, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-1
(Mus
musculus;
synthetic
construct) 		4 / 6 ARG A 141
LEU A 136
MET A 137
ASP A 139
 None
 0.97A 4cevE-2rgtA:
undetectable
4cevF-2rgtA:
undetectable		 4cevE-2rgtA:
18.51
4cevF-2rgtA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2rgt FUSION OF
LIM/HOMEOBOX PROTEIN
LHX3, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-1
(Mus
musculus;
synthetic
construct) 		3 / 3 VAL A 266
ALA A 268
PHE A 134
 None
 0.87A 4olbA-2rgtA:
undetectable		 4olbA-2rgtA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2rgt FUSION OF
LIM/HOMEOBOX PROTEIN
LHX3, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-1
(Mus
musculus;
synthetic
construct) 		3 / 3 VAL A 266
ALA A 268
PHE A 134
 None
 0.94A 4w5nA-2rgtA:
undetectable		 4w5nA-2rgtA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2rgt FUSION OF
LIM/HOMEOBOX PROTEIN
LHX3, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-1
(Mus
musculus;
synthetic
construct) 		3 / 3 VAL A 266
ALA A 268
PHE A 134
 None
 0.88A 4z4iA-2rgtA:
undetectable		 4z4iA-2rgtA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2rgt FUSION OF
LIM/HOMEOBOX PROTEIN
LHX3, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-1
(Mus
musculus;
synthetic
construct) 		3 / 3 VAL A 266
ALA A 268
PHE A 134
 None
 0.88A 5js1A-2rgtA:
undetectable		 5js1A-2rgtA:
11.71