SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 133
THR A 135
PRO A 132
 None
 0.78A 1dscC-2rgwA:
undetectable		 1dscC-2rgwA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 8 ALA A 294
GLY A 288
ILE A 289
ILE A 122
ILE A 295
 None
 1.27A 1hshD-2rgwA:
undetectable		 1hshD-2rgwA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 133
THR A 135
PRO A 132
 None
 0.83A 1mnvD-2rgwA:
undetectable		 1mnvD-2rgwA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ASP A 138
LEU A  19
ALA A 172
LEU A 169
 None
 1.01A 1nh8A-2rgwA:
undetectable		 1nh8A-2rgwA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 133
THR A 135
PRO A 132
 None
 0.85A 1unjL-2rgwA:
undetectable		 1unjL-2rgwA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 133
THR A 135
PRO A 132
 None
 0.85A 1unjR-2rgwA:
undetectable		 1unjR-2rgwA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 133
THR A 135
PRO A 132
 None
 0.82A 1unjW-2rgwA:
undetectable		 1unjW-2rgwA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 135
PRO A 132
THR A 133
 None
 0.86A 1unjX-2rgwA:
undetectable		 1unjX-2rgwA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 133
THR A 135
PRO A 132
 None
 0.84A 1unjX-2rgwA:
undetectable		 1unjX-2rgwA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 135
PRO A 132
THR A 133
 None
 0.85A 1unmE-2rgwA:
undetectable		 1unmE-2rgwA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 133
THR A 135
PRO A 132
 None
 0.81A 1unmE-2rgwA:
undetectable		 1unmE-2rgwA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 133
THR A 135
PRO A 132
 None
 0.82A 1unmF-2rgwA:
undetectable		 1unmF-2rgwA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 144
TYR A 287
LYS A 283
 None
 0.76A 1uujB-2rgwA:
undetectable		 1uujB-2rgwA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A  43
GLY A  67
ILE A 300
ILE A  99
 None
 0.86A 2q9rA-2rgwA:
undetectable		 2q9rA-2rgwA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R6V_A_NCAA174_0
(UNCHARACTERIZED
PROTEIN PH0856)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 TYR A 223
ASP A 138
ARG A 292
HIS A 131
 None
 1.24A 2r6vA-2rgwA:
0.0		 2r6vA-2rgwA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A 100
ARG A  55
MET A  72
THR A  73
 None
 1.34A 3abkN-2rgwA:
undetectable
3abkW-2rgwA:
undetectable		 3abkN-2rgwA:
19.69
3abkW-2rgwA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A 166
VAL A 170
LEU A 173
SER A 174
 None
 0.48A 3hs6B-2rgwA:
undetectable		 3hs6B-2rgwA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A  58
PRO A 132
ILE A  90
THR A  89
LEU A 102
 None
 1.07A 3iv6A-2rgwA:
undetectable		 3iv6A-2rgwA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 166
VAL A 170
LEU A 173
ILE A 204
LEU A 160
 None
 0.94A 3n8yB-2rgwA:
undetectable		 3n8yB-2rgwA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 TYR A 287
LEU A 299
LYS A 297
 None
 0.76A 3sueD-2rgwA:
undetectable		 3sueD-2rgwA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A 168
LEU A 169
ILE A  18
ILE A  15
LEU A 175
 None
 1.06A 3w67B-2rgwA:
undetectable		 3w67B-2rgwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 184
LEU A 191
ILE A 219
VAL A 170
LEU A 169
 None
 0.89A 3w68D-2rgwA:
undetectable		 3w68D-2rgwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 TYR A 223
ASP A 138
ARG A 292
HIS A 131
 None
 1.24A 3zodA-2rgwA:
undetectable		 3zodA-2rgwA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 295
LEU A 136
ILE A   5
GLY A  11
 None
 0.75A 4hb6A-2rgwA:
undetectable		 4hb6A-2rgwA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 241
GLY A 243
LYS A 246
 None
 0.61A 4k50A-2rgwA:
undetectable		 4k50A-2rgwA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 241
GLY A 243
LYS A 246
 None
 0.62A 4k50E-2rgwA:
undetectable		 4k50E-2rgwA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 241
GLY A 243
LYS A 246
 None
 0.59A 4k50I-2rgwA:
undetectable		 4k50I-2rgwA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ILE A  18
MET A 143
ARG A 144
 None
 0.94A 4lnwA-2rgwA:
undetectable		 4lnwA-2rgwA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 101
LYS A 130
MET A   7
 None
 0.89A 5nknA-2rgwA:
undetectable		 5nknA-2rgwA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2rgw ASPARTATE
CARBAMOYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 294
LEU A 299
VAL A  46
THR A 133
LEU A 136
 None
 1.16A 6djzC-2rgwA:
undetectable		 6djzC-2rgwA:
20.82