SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rgy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		4 / 8 HIS A 318
SER A 352
ARG A 354
TYR A 305
 None
 1.08A 1eqbA-2rgyA:
3.0
1eqbB-2rgyA:
3.0		 1eqbA-2rgyA:
21.18
1eqbB-2rgyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		4 / 8 TYR A 305
HIS A 318
SER A 352
ARG A 354
 None
 1.09A 1eqbA-2rgyA:
2.2
1eqbB-2rgyA:
3.0		 1eqbA-2rgyA:
21.18
1eqbB-2rgyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		4 / 8 HIS A 318
SER A 352
ARG A 354
TYR A 305
 None
 1.09A 1eqbC-2rgyA:
3.0
1eqbD-2rgyA:
2.0		 1eqbC-2rgyA:
21.18
1eqbD-2rgyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		4 / 8 TYR A 305
HIS A 318
SER A 352
ARG A 354
 None
 1.09A 1eqbC-2rgyA:
3.0
1eqbD-2rgyA:
2.0		 1eqbC-2rgyA:
21.18
1eqbD-2rgyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		4 / 4 VAL A 349
LEU A 231
ILE A 201
LEU A 200
 None
 0.96A 2byoA-2rgyA:
undetectable		 2byoA-2rgyA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		4 / 8 ASP A 275
SER A 316
TYR A 301
HIS A 318
 None
 1.37A 2v0gA-2rgyA:
undetectable		 2v0gA-2rgyA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		4 / 8 TYR A 305
HIS A 318
SER A 352
ARG A 354
 None
 1.00A 2vmyA-2rgyA:
2.7
2vmyB-2rgyA:
2.7		 2vmyA-2rgyA:
21.62
2vmyB-2rgyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		3 / 3 PHE A 344
ASN A 327
PHE A 347
 None
 1.09A 2zbuD-2rgyA:
5.6		 2zbuD-2rgyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		3 / 3 GLU A 110
TRP A 341
LYS A 105
 None
 1.49A 4k7aA-2rgyA:
undetectable		 4k7aA-2rgyA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		5 / 12 VAL A 210
GLY A 213
PHE A 271
GLY A 300
ASP A 302
 None
 1.41A 4pevB-2rgyA:
18.4		 4pevB-2rgyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		5 / 11 PHE A 271
ASP A 275
TYR A  99
GLY A 193
GLY A 300
 None
 1.17A 4xnxA-2rgyA:
undetectable		 4xnxA-2rgyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		4 / 4 PHE A  91
ASP A 154
GLY A 123
SER A 152
 None
 1.09A 4xp9C-2rgyA:
undetectable		 4xp9C-2rgyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		4 / 7 PHE A 267
ALA A 281
GLY A 253
TYR A 254
 None
 1.10A 5uxdA-2rgyA:
undetectable		 5uxdA-2rgyA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		4 / 6 VAL A 137
LEU A 163
ARG A 175
VAL A 150
 None
 0.98A 5x7zA-2rgyA:
undetectable		 5x7zA-2rgyA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		4 / 6 GLU A 346
PHE A 347
VAL A 349
PRO A 320
 None
 0.95A 6fgdA-2rgyA:
5.9		 6fgdA-2rgyA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Paraburkholderia
phymatum) 		4 / 7 THR A 325
ARG A 112
HIS A 115
ASP A 108
 None
 1.27A 6mn4E-2rgyA:
undetectable		 6mn4E-2rgyA:
22.92