SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 2rgz HEME OXYGENASE 2
(Homo
sapiens) 		5 / 12 ILE A  62
PHE A  67
LEU A  69
LEU A 177
PHE A 116
 None
 1.09A 1og5B-2rgzA:
undetectable		 1og5B-2rgzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 2rgz HEME OXYGENASE 2
(Homo
sapiens) 		4 / 6 LEU A  74
TYR A  75
ALA A 127
LEU A 109
 None
 0.78A 3ravA-2rgzA:
5.0		 3ravA-2rgzA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 2rgz HEME OXYGENASE 2
(Homo
sapiens) 		4 / 6 LEU A  74
TYR A  75
ALA A 127
LEU A 109
 None
 0.80A 3rd0A-2rgzA:
4.1		 3rd0A-2rgzA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 2rgz HEME OXYGENASE 2
(Homo
sapiens) 		5 / 12 MET A 158
LEU A  97
MET A 206
THR A  41
PHE A 227
 None
None
None
None
HEM  A 300 (-4.1A)
 1.46A 4p6xG-2rgzA:
undetectable		 4p6xG-2rgzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 2rgz HEME OXYGENASE 2
(Homo
sapiens) 		5 / 12 MET A 158
LEU A  97
MET A 206
THR A  41
PHE A 227
 None
None
None
None
HEM  A 300 (-4.1A)
 1.47A 4p6xI-2rgzA:
undetectable		 4p6xI-2rgzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2rgz HEME OXYGENASE 2
(Homo
sapiens) 		4 / 6 LEU A  97
TYR A  98
PRO A  96
GLU A 102
 None
 1.21A 4z4gA-2rgzA:
undetectable		 4z4gA-2rgzA:
14.90