SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rha'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Novosphingobium
aromaticivorans) 		5 / 10 VAL A 153
ARG A 155
ILE A 157
PRO A  89
GLY A 148
 None
 1.16A 13gsA-2rhaA:
undetectable		 13gsA-2rhaA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Novosphingobium
aromaticivorans) 		5 / 9 VAL A 153
ARG A 155
ILE A 157
PRO A  89
GLY A 148
 None
 1.16A 13gsB-2rhaA:
undetectable		 13gsB-2rhaA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Novosphingobium
aromaticivorans) 		5 / 12 SER A 175
LEU A 114
LEU A  67
ASP A  70
MET A  71
 GOL  A 225 (-3.9A)
None
None
None
None
 1.43A 1e7wA-2rhaA:
undetectable		 1e7wA-2rhaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Novosphingobium
aromaticivorans) 		4 / 6 TYR A 163
ILE A 101
TYR A 104
GLY A 168
 None
 1.10A 1maaB-2rhaA:
undetectable
1maaD-2rhaA:
undetectable		 1maaB-2rhaA:
17.67
1maaD-2rhaA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Novosphingobium
aromaticivorans) 		4 / 8 VAL A 166
ASP A 102
HIS A  96
LEU A  93
 None
 1.04A 1pk2A-2rhaA:
undetectable		 1pk2A-2rhaA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Novosphingobium
aromaticivorans) 		4 / 6 TYR A 104
MET A 115
ILE A 129
LEU A 134
 None
None
None
GOL  A 229 ( 4.4A)
 1.15A 2wekB-2rhaA:
undetectable		 2wekB-2rhaA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Novosphingobium
aromaticivorans) 		4 / 7 TYR A  54
GLY A  15
ALA A  16
LEU A  20
 None
SO4  A 216 (-3.3A)
None
None
 0.63A 2wekB-2rhaA:
undetectable		 2wekB-2rhaA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Novosphingobium
aromaticivorans) 		4 / 5 PHE A 162
LEU A  81
ILE A 205
VAL A 202
 None
 0.89A 3wrkA-2rhaA:
undetectable		 3wrkA-2rhaA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Novosphingobium
aromaticivorans) 		5 / 10 THR A 201
ILE A 205
PHE A 204
GLY A 168
ALA A 170
 None
 1.03A 5mxbA-2rhaA:
undetectable		 5mxbA-2rhaA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Novosphingobium
aromaticivorans) 		4 / 7 LEU A  67
VAL A  78
TYR A 163
SER A  77
 None
 1.31A 5umwA-2rhaA:
undetectable
5umwF-2rhaA:
undetectable		 5umwA-2rhaA:
13.15
5umwF-2rhaA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Novosphingobium
aromaticivorans) 		4 / 8 ASP A 187
ARG A  29
GLU A  30
ARG A  69
 SO4  A 218 (-4.0A)
SO4  A 218 ( 2.9A)
GOL  A 224 (-2.7A)
None
 1.20A 6fbvD-2rhaA:
undetectable		 6fbvD-2rhaA:
9.49