SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rhd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2rhd SMALL GTP BINDING
PROTEIN RAB1A
(Cryptosporidium
parvum) 		4 / 8 GLY A  84
HIS A  83
ALA A 111
ILE A  85
 None
 0.82A 1gtnP-2rhdA:
undetectable
1gtnQ-2rhdA:
undetectable		 1gtnP-2rhdA:
21.51
1gtnQ-2rhdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 2rhd SMALL GTP BINDING
PROTEIN RAB1A
(Cryptosporidium
parvum) 		5 / 12 ILE A 146
TYR A  89
VAL A  91
LEU A 119
LEU A  25
 None
 0.92A 2rctA-2rhdA:
undetectable		 2rctA-2rhdA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2rhd SMALL GTP BINDING
PROTEIN RAB1A
(Cryptosporidium
parvum) 		5 / 12 ILE A  86
ALA A 162
ALA A 153
LEU A  25
PHE A 148
 None
None
GDP  A3800 (-3.7A)
None
None
 1.05A 3gwsX-2rhdA:
undetectable		 3gwsX-2rhdA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2rhd SMALL GTP BINDING
PROTEIN RAB1A
(Cryptosporidium
parvum) 		5 / 12 ILE A 146
TYR A  89
VAL A  91
LEU A 119
LEU A  25
 None
 0.93A 4qzuC-2rhdA:
undetectable		 4qzuC-2rhdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 2rhd SMALL GTP BINDING
PROTEIN RAB1A
(Cryptosporidium
parvum) 		3 / 3 LYS A  22
GLN A 102
ASN A  99
 GDP  A3800 (-2.6A)
None
MG  A1002 ( 4.7A)
 0.77A 5l2tA-2rhdA:
undetectable		 5l2tA-2rhdA:
18.75