SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rhk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 2rhk NON-STRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		3 / 3 VAL A 194
VAL A 192
TRP A 203
 None
None
NO3  A   3 (-4.3A)
 0.84A 1av2A-2rhkA:
undetectable
1av2B-2rhkA:
undetectable		 1av2A-2rhkA:
10.19
1av2B-2rhkA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2rhk NON-STRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		5 / 11 ALA A 177
GLU A 159
ARG A 118
ALA A 132
LEU A 144
 None
 1.32A 1mjlA-2rhkA:
undetectable
1mjlB-2rhkA:
undetectable		 1mjlA-2rhkA:
23.74
1mjlB-2rhkA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2rhk NON-STRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		5 / 11 ALA A 155
LEU A 181
LEU A 130
LYS A 126
ASN A 190
 NO3  A   2 ( 3.7A)
None
None
NO3  A   2 (-2.7A)
None
 1.12A 2ceoA-2rhkA:
undetectable		 2ceoA-2rhkA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 2rhk NON-STRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		5 / 10 ALA A 155
LEU A 181
LEU A 130
LYS A 126
ASN A 190
 NO3  A   2 ( 3.7A)
None
None
NO3  A   2 (-2.7A)
None
 1.12A 2ceoB-2rhkA:
undetectable		 2ceoB-2rhkA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 2rhk CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 4
(Homo
sapiens) 		3 / 3 CYH C  76
CYH C  82
HIS C  86
 ZN  C 501 (-2.3A)
ZN  C 501 (-2.4A)
ZN  C 501 (-3.4A)
 0.82A 2iwkA-2rhkC:
undetectable		 2iwkA-2rhkC:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 2rhk CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 4
(Homo
sapiens) 		3 / 3 CYH C  76
CYH C  82
HIS C  86
 ZN  C 501 (-2.3A)
ZN  C 501 (-2.4A)
ZN  C 501 (-3.4A)
 0.81A 2iwkB-2rhkC:
undetectable		 2iwkB-2rhkC:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 2rhk NON-STRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		5 / 12 VAL A 194
GLY A 179
GLY A 158
GLY A 183
ILE A 182
 None
None
None
None
NO3  A   3 ( 4.4A)
 0.94A 4q5mA-2rhkA:
undetectable		 4q5mA-2rhkA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 2rhk NON-STRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		3 / 3 GLU A 172
ILE A 137
ALA A 202
 None
 0.44A 4wnwB-2rhkA:
undetectable		 4wnwB-2rhkA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 2rhk NON-STRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		4 / 8 ASP A 173
ASN A 176
ALA A 177
VAL A 180
 None
 0.69A 4zbqA-2rhkA:
undetectable		 4zbqA-2rhkA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2rhk NON-STRUCTURAL
PROTEIN 1
(Influenza
A
virus) 		5 / 12 GLY A 179
GLY A 183
GLY A 184
LEU A 185
LEU A 147
 None
 0.97A 5c0oF-2rhkA:
undetectable		 5c0oF-2rhkA:
18.15