SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rhq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 5 HIS B 528
LEU B 671
LEU B 534
GLY B 649
 None
 1.10A 1a4lB-2rhqB:
undetectable		 1a4lB-2rhqB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		5 / 11 GLU B 471
ARG B 459
GLU A 258
ALA B 473
GLY B 477
 None
 1.31A 1cmaA-2rhqB:
undetectable
1cmaB-2rhqB:
undetectable		 1cmaA-2rhqB:
10.60
1cmaB-2rhqB:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		5 / 10 GLU B 471
ARG B 459
GLU A 258
ALA B 473
GLY B 477
 None
 1.26A 1cmcA-2rhqB:
undetectable
1cmcB-2rhqB:
undetectable		 1cmcA-2rhqB:
10.60
1cmcB-2rhqB:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ALA B 625
ARG B 577
LEU B 506
LEU B 515
LEU B 689
 None
 1.41A 1eiiA-2rhqB:
undetectable		 1eiiA-2rhqB:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		5 / 12 ALA B 473
GLY B 477
GLU B 471
ARG B 459
GLU A 258
 None
 1.24A 1mj2A-2rhqB:
undetectable
1mj2B-2rhqB:
undetectable		 1mj2A-2rhqB:
10.60
1mj2B-2rhqB:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		5 / 12 ALA B 473
GLY B 477
GLU B 471
ARG B 459
GLU A 258
 None
 1.25A 1mj2C-2rhqB:
undetectable
1mj2D-2rhqB:
undetectable		 1mj2C-2rhqB:
10.60
1mj2D-2rhqB:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		5 / 12 ALA B 473
GLY B 477
GLU B 471
ARG B 459
GLU A 258
 None
 1.25A 1mjoC-2rhqB:
undetectable
1mjoD-2rhqB:
undetectable		 1mjoC-2rhqB:
10.60
1mjoD-2rhqB:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 6 LEU B 440
LEU B 188
ILE B  30
GLU B 471
 None
 1.07A 1mt1A-2rhqB:
undetectable
1mt1F-2rhqB:
1.5		 1mt1A-2rhqB:
5.91
1mt1F-2rhqB:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 6 SER A 174
THR A 173
ASN A 142
LEU A 168
 GAX  A 352 (-2.8A)
None
None
None
 1.34A 1mxdA-2rhqA:
undetectable		 1mxdA-2rhqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 7 LEU B 440
LEU B 188
ILE B  30
GLU B 471
 None
 0.97A 1n13I-2rhqB:
undetectable
1n13L-2rhqB:
1.3		 1n13I-2rhqB:
5.91
1n13L-2rhqB:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.38A 1nncA-2rhqB:
undetectable		 1nncA-2rhqB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 5 TYR A 162
SER A 160
THR A 171
ASN A 142
 None
 1.44A 1yvpA-2rhqA:
undetectable		 1yvpA-2rhqA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 11 ILE B 620
VAL B 628
GLY B 627
LEU B 515
SER A 105
 None
 1.16A 2bxeA-2rhqB:
undetectable		 2bxeA-2rhqB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ILE B 620
VAL B 628
GLY B 627
LEU B 515
SER A 105
 None
 1.11A 2bxeB-2rhqB:
undetectable		 2bxeB-2rhqB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 8 ILE B 475
ARG B 459
LEU B 440
GLU B 471
 None
 0.87A 2cdqA-2rhqB:
undetectable		 2cdqA-2rhqB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.39A 2cmlA-2rhqB:
undetectable		 2cmlA-2rhqB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.39A 2cmlB-2rhqB:
undetectable		 2cmlB-2rhqB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.38A 2cmlC-2rhqB:
undetectable		 2cmlC-2rhqB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.44A 2cmlD-2rhqB:
undetectable		 2cmlD-2rhqB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 LEU B 604
VAL B 675
LEU B 681
GLY B 649
PHE B 532
 None
 1.12A 2f8lA-2rhqB:
undetectable		 2f8lA-2rhqB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 PHE A 312
PRO A 195
THR A 115
VAL A 116
LEU A 124
 None
 1.41A 2fj1A-2rhqA:
undetectable		 2fj1A-2rhqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		3 / 3 ASP B 678
ASN B 679
THR B 605
 None
 0.69A 2q63B-2rhqB:
undetectable		 2q63B-2rhqB:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 11 ASP B  10
GLN B 162
VAL B 163
ILE B   3
VAL B 185
 None
 1.43A 2vcdA-2rhqB:
undetectable		 2vcdA-2rhqB:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 6 PRO B 559
ILE B 603
ASN B 679
LEU B 681
 None
 1.19A 2wekB-2rhqB:
undetectable		 2wekB-2rhqB:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 7 ASN A 185
GLY A 186
VAL A 190
ASP A 303
 None
 0.87A 2y05A-2rhqA:
undetectable
2y05B-2rhqA:
undetectable		 2y05A-2rhqA:
23.29
2y05B-2rhqA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 7 TYR B 691
LEU B 636
VAL B 632
THR B 509
 None
 1.06A 2zaxA-2rhqB:
undetectable		 2zaxA-2rhqB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 THR B 294
GLY B 327
ASP B 299
LEU B 321
ASN B 314
 None
 1.23A 2zw9B-2rhqB:
undetectable		 2zw9B-2rhqB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		5 / 11 GLY B 582
GLN B 517
GLU B 580
ARG B 499
GLY A 196
 None
 1.41A 3ablA-2rhqB:
0.0
3ablB-2rhqB:
0.0
3ablT-2rhqB:
0.0		 3ablA-2rhqB:
21.17
3ablB-2rhqB:
15.60
3ablT-2rhqB:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		5 / 11 GLY B 582
GLN B 517
GLU B 580
ARG B 499
GLY A 196
 None
 1.31A 3ag3A-2rhqB:
0.0
3ag3B-2rhqB:
0.0
3ag3T-2rhqB:
0.0		 3ag3A-2rhqB:
21.17
3ag3B-2rhqB:
15.60
3ag3T-2rhqB:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		5 / 11 ARG B 499
GLY A 196
GLY B 582
GLN B 517
GLU B 580
 None
 1.37A 3ag3G-2rhqB:
undetectable
3ag3N-2rhqB:
0.0
3ag3O-2rhqB:
undetectable		 3ag3G-2rhqB:
7.14
3ag3N-2rhqB:
21.17
3ag3O-2rhqB:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		4 / 4 ARG B 356
ASP A 159
ASP A 156
PRO A 153
 None
 1.13A 3fgrB-2rhqB:
undetectable		 3fgrB-2rhqB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		3 / 3 ARG A 114
GLU B 508
TYR B 579
 None
 0.92A 3k37B-2rhqA:
undetectable		 3k37B-2rhqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 GLN A 214
VAL A 292
GLY A 217
ARG A 179
ALA A 178
 GAX  A 352 (-4.2A)
GAX  A 352 ( 4.5A)
None
None
GAX  A 352 ( 4.9A)
 1.09A 3keeB-2rhqA:
undetectable		 3keeB-2rhqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		6 / 12 ASP B  85
VAL B  84
ILE B  50
GLY B  48
VAL B  47
ILE B 140
 None
 1.48A 3nu5A-2rhqB:
undetectable		 3nu5A-2rhqB:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		6 / 10 ASP B  85
VAL B  84
ILE B  50
GLY B  48
VAL B  47
ILE B 140
 None
 1.44A 3oxvB-2rhqB:
undetectable		 3oxvB-2rhqB:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		8 / 12 GLN A 214
PHE A 254
PHE A 256
THR A 257
GLY A 288
GLY A 290
ALA A 311
GLY A 313
 GAX  A 352 (-4.2A)
GAX  A 352 (-3.8A)
GAX  A 352 (-4.6A)
GAX  A 352 (-3.9A)
GAX  A 352 (-3.2A)
None
GAX  A 352 (-3.4A)
GAX  A 352 (-3.2A)
 0.69A 3tegA-2rhqA:
24.6		 3tegA-2rhqA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		8 / 12 GLU A 216
PHE A 254
PHE A 256
THR A 257
GLY A 288
GLY A 290
ALA A 311
GLY A 313
 GAX  A 352 (-3.7A)
GAX  A 352 (-3.8A)
GAX  A 352 (-4.6A)
GAX  A 352 (-3.9A)
GAX  A 352 (-3.2A)
None
GAX  A 352 (-3.4A)
GAX  A 352 (-3.2A)
 0.62A 3tegA-2rhqA:
24.6		 3tegA-2rhqA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		7 / 12 SER A 174
GLN A 214
PHE A 256
THR A 257
GLY A 290
ALA A 311
GLY A 313
 GAX  A 352 (-2.8A)
GAX  A 352 (-4.2A)
GAX  A 352 (-4.6A)
GAX  A 352 (-3.9A)
None
GAX  A 352 (-3.4A)
GAX  A 352 (-3.2A)
 0.81A 3tegA-2rhqA:
24.6		 3tegA-2rhqA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		7 / 12 SER A 174
GLU A 216
PHE A 256
THR A 257
GLY A 290
ALA A 311
GLY A 313
 GAX  A 352 (-2.8A)
GAX  A 352 (-3.7A)
GAX  A 352 (-4.6A)
GAX  A 352 (-3.9A)
None
GAX  A 352 (-3.4A)
GAX  A 352 (-3.2A)
 0.99A 3tegA-2rhqA:
24.6		 3tegA-2rhqA:
24.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 9 HIS A 172
SER A 174
GLN A 214
ALA A 311
GLY A 313
 None
GAX  A 352 (-2.8A)
GAX  A 352 (-4.2A)
GAX  A 352 (-3.4A)
GAX  A 352 (-3.2A)
 0.71A 3tehA-2rhqA:
28.4		 3tehA-2rhqA:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 9 HIS A 172
SER A 174
GLU A 216
ALA A 311
GLY A 313
 None
GAX  A 352 (-2.8A)
GAX  A 352 (-3.7A)
GAX  A 352 (-3.4A)
GAX  A 352 (-3.2A)
 0.79A 3tehA-2rhqA:
28.4		 3tehA-2rhqA:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 9 HIS A 172
SER A 174
GLU A 216
VAL A 292
ALA A 311
 None
GAX  A 352 (-2.8A)
GAX  A 352 (-3.7A)
GAX  A 352 ( 4.5A)
GAX  A 352 (-3.4A)
 1.36A 3tehA-2rhqA:
28.4		 3tehA-2rhqA:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 7 HIS B 272
LEU B 298
GLY B 323
GLU B 342
PHE B 368
 None
 0.97A 3tehB-2rhqB:
45.8		 3tehB-2rhqB:
35.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		6 / 7 PRO B 270
HIS B 272
GLY B 323
GLU B 342
ALA B 364
PHE B 368
 None
 0.95A 3tehB-2rhqB:
45.8		 3tehB-2rhqB:
35.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.38A 3ticA-2rhqB:
undetectable		 3ticA-2rhqB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.38A 3ticB-2rhqB:
undetectable		 3ticB-2rhqB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.38A 3ticC-2rhqB:
undetectable		 3ticC-2rhqB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.39A 3ticD-2rhqB:
undetectable		 3ticD-2rhqB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 9 LEU B 157
LEU B 122
ILE B 119
ILE B  50
GLU B 124
 None
 1.31A 3tmzA-2rhqB:
undetectable		 3tmzA-2rhqB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ILE B  42
LEU B 122
LEU B 154
PRO B 100
ILE B 103
 None
 0.91A 3vrmA-2rhqB:
undetectable		 3vrmA-2rhqB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		3 / 3 ASP A 221
GLU B 490
GLY B 489
 None
 0.44A 3w9tA-2rhqA:
undetectable		 3w9tA-2rhqA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 PHE B 143
PRO B 144
LEU B 387
TYR B 262
ALA B 243
 None
 1.41A 4a84A-2rhqB:
3.9		 4a84A-2rhqB:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 7 GLU A 118
GLU A 347
TYR A 324
VAL A 277
 None
 1.00A 4a97A-2rhqA:
undetectable		 4a97A-2rhqA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ILE A 284
GLU A 118
GLU A 347
TYR A 324
VAL A 277
 None
 0.99A 4a97A-2rhqA:
0.0
4a97B-2rhqA:
undetectable		 4a97A-2rhqA:
19.45
4a97B-2rhqA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ILE A 284
GLU A 118
GLU A 347
TYR A 324
VAL A 277
 None
 1.01A 4a97B-2rhqA:
undetectable
4a97C-2rhqA:
undetectable		 4a97B-2rhqA:
19.45
4a97C-2rhqA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 7 GLU A 118
GLU A 347
TYR A 324
VAL A 277
 None
 1.04A 4a97D-2rhqA:
undetectable		 4a97D-2rhqA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 7 GLU A 118
GLU A 347
TYR A 324
VAL A 277
 None
 0.98A 4a97H-2rhqA:
undetectable		 4a97H-2rhqA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 8 ASP B  68
ILE B  69
GLY B  70
VAL B  95
 None
 0.64A 4acbB-2rhqB:
undetectable
4acbC-2rhqB:
undetectable		 4acbB-2rhqB:
21.80
4acbC-2rhqB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.44A 4b7qA-2rhqB:
undetectable		 4b7qA-2rhqB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.37A 4b7qB-2rhqB:
undetectable		 4b7qB-2rhqB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.43A 4cpzD-2rhqB:
undetectable		 4cpzD-2rhqB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 8 LEU B 730
ILE B 734
ILE B 717
THR B 745
 None
 0.78A 4em2A-2rhqB:
undetectable		 4em2A-2rhqB:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 7 GLU B 580
GLU B 598
TYR B 599
ARG B 554
 None
 0.97A 4fgzA-2rhqB:
undetectable		 4fgzA-2rhqB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 SER B 403
ALA B 322
GLN B 269
ILE B 372
GLY B 404
 None
 1.06A 4iilA-2rhqB:
undetectable		 4iilA-2rhqB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 11 ALA B 156
ILE B 246
PRO B 144
THR B 145
VAL B 147
 None
 1.06A 4l1aA-2rhqB:
undetectable		 4l1aA-2rhqB:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 8 GLU B 688
TYR B 579
GLU B 580
TYR B 685
 None
 0.96A 4mj8A-2rhqB:
undetectable
4mj8C-2rhqB:
undetectable		 4mj8A-2rhqB:
13.25
4mj8C-2rhqB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.40A 4mwrA-2rhqB:
undetectable		 4mwrA-2rhqB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 HIS A 172
LEU A 218
VAL A 220
MET A 181
LEU A 148
 None
GAX  A 352 ( 4.3A)
None
GAX  A 352 ( 4.8A)
None
 1.34A 4o8fB-2rhqA:
undetectable		 4o8fB-2rhqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ILE B 519
LEU B 578
HIS B 560
LEU B 561
ALA B 564
 None
 1.05A 4p65F-2rhqB:
undetectable
4p65H-2rhqB:
undetectable
4p65K-2rhqB:
undetectable
4p65L-2rhqB:
undetectable		 4p65F-2rhqB:
4.56
4p65H-2rhqB:
4.56
4p65K-2rhqB:
4.11
4p65L-2rhqB:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 11 ILE B 310
SER B 330
ILE B 319
ARG B 287
THR B 354
 None
 1.34A 4p68A-2rhqB:
undetectable		 4p68A-2rhqB:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 6 GLU B 563
TYR B 567
THR A 334
HIS B 550
 None
 1.19A 4qwpA-2rhqB:
undetectable		 4qwpA-2rhqB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 THR A 232
VAL A 236
VAL A 220
GLN A 177
GLU A 216
 None
None
None
GAX  A 352 (-4.0A)
GAX  A 352 (-3.7A)
 1.11A 4s0vA-2rhqA:
undetectable		 4s0vA-2rhqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 THR A 113
VAL A 116
THR B 520
GLU A 135
ILE B 581
 None
 1.32A 4s0vA-2rhqA:
undetectable		 4s0vA-2rhqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 PHE A 310
LEU A 218
GLY A 127
LEU A 126
PHE A 123
 None
GAX  A 352 ( 4.3A)
None
None
None
 1.13A 4wnwA-2rhqA:
undetectable		 4wnwA-2rhqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 7 SER B 281
ARG B 287
SER B 313
GLU B 283
 None
 1.47A 4xzkA-2rhqB:
undetectable		 4xzkA-2rhqB:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 6 ASP B 152
PRO B 144
THR B 145
VAL B 147
 None
 0.82A 4yoaA-2rhqB:
undetectable		 4yoaA-2rhqB:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		5 / 11 ARG B 499
GLY A 196
GLY B 582
GLN B 517
GLU B 580
 None
 1.33A 5b1bG-2rhqB:
0.0
5b1bN-2rhqB:
0.0
5b1bO-2rhqB:
0.0		 5b1bG-2rhqB:
7.14
5b1bN-2rhqB:
21.17
5b1bO-2rhqB:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 7 VAL B 420
ASN B 421
ILE B 424
VAL B 472
 None
 0.69A 5bmvC-2rhqB:
undetectable		 5bmvC-2rhqB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		3 / 3 ASP B 378
SER B 402
TYR B 223
 None
 0.86A 5glmA-2rhqB:
undetectable		 5glmA-2rhqB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		3 / 3 ARG B 577
ASN B 516
ASP A 336
 None
 0.92A 5gwxA-2rhqB:
undetectable		 5gwxA-2rhqB:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 7 ILE B 519
HIS B 560
LEU B 561
ALA B 564
 None
 0.75A 5hrqE-2rhqB:
undetectable
5hrqF-2rhqB:
undetectable
5hrqJ-2rhqB:
undetectable		 5hrqE-2rhqB:
4.11
5hrqF-2rhqB:
5.97
5hrqJ-2rhqB:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		4 / 6 GLY B 582
ASP A 317
ILE A 215
TYR A 199
 None
 1.02A 5iwuA-2rhqB:
undetectable		 5iwuA-2rhqB:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ALA B 322
HIS B 272
LEU B 321
ALA B 320
PHE B 274
 None
 1.21A 5k9dA-2rhqB:
undetectable		 5k9dA-2rhqB:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.43A 5l17A-2rhqB:
undetectable		 5l17A-2rhqB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 5 ALA B 656
VAL B 658
LYS B 626
PHE B 622
 None
 0.68A 5of1A-2rhqB:
undetectable		 5of1A-2rhqB:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 5 ALA B 656
VAL B 658
LYS B 626
PHE B 622
 None
 0.95A 5of1B-2rhqB:
undetectable		 5of1B-2rhqB:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		3 / 3 LEU B 271
VAL B 377
ASP B 378
 None
 0.43A 5x23A-2rhqB:
undetectable		 5x23A-2rhqB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		3 / 3 ASP B 461
PHE B 442
ARG B 458
 None
 1.06A 5yw0A-2rhqB:
undetectable		 5yw0A-2rhqB:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		4 / 4 ILE B 519
LEU B 578
HIS B 560
ALA B 564
 None
 1.04A 6ck2C-2rhqB:
undetectable
6ck2D-2rhqB:
undetectable		 6ck2C-2rhqB:
4.11
6ck2D-2rhqB:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ALA B 693
LEU B 689
PHE B 622
LEU B 638
ALA B 633
 None
 1.08A 6djzC-2rhqB:
undetectable		 6djzC-2rhqB:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ILE A 130
LEU A 122
PHE A 123
GLY A 217
PHE A 312
 None
 1.01A 6dwnC-2rhqA:
undetectable		 6dwnC-2rhqA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		3 / 3 VAL B 228
ALA B 207
GLN B 276
 None
 0.68A 6gb9A-2rhqB:
undetectable		 6gb9A-2rhqB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Staphylococcus
haemolyticus) 		5 / 12 ARG B 383
GLU B 266
GLU B   6
ARG B 244
TYR B 262
 None
 1.41A 6hcxA-2rhqB:
undetectable		 6hcxA-2rhqB:
8.19