SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rhz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2rhz LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 PHE A 281
ILE A 247
PRO A 252
PHE A 272
 None
 1.26A 4fgkA-2rhzA:
undetectable		 4fgkA-2rhzA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_A_SFYA807_0
(SEPIAPTERIN
REDUCTASE)		 2rhz LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN
(Homo
sapiens) 		5 / 11 SER A 394
CYH A 390
PHE A 375
TYR A 388
ALA A 365
 None
 1.16A 4hwkA-2rhzA:
0.0		 4hwkA-2rhzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		 2rhz LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN
(Homo
sapiens) 		5 / 11 SER A 394
CYH A 390
PHE A 375
TYR A 388
ALA A 365
 None
 1.18A 4hwkB-2rhzA:
undetectable		 4hwkB-2rhzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 2rhz LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 SER A 394
CYH A 390
PHE A 375
TYR A 388
ALA A 365
 None
 1.16A 4hwkC-2rhzA:
undetectable		 4hwkC-2rhzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 2rhz LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN
(Homo
sapiens) 		5 / 11 SER A 394
CYH A 390
PHE A 375
TYR A 388
ALA A 365
 None
 1.15A 4hwkD-2rhzA:
undetectable		 4hwkD-2rhzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 2rhz LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 SER A 394
CYH A 390
PHE A 375
TYR A 388
ALA A 365
 None
 1.17A 4j7xA-2rhzA:
undetectable		 4j7xA-2rhzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 2rhz LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 SER A 394
CYH A 390
PHE A 375
TYR A 388
ALA A 365
 None
 1.16A 4j7xB-2rhzA:
undetectable		 4j7xB-2rhzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2rhz LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN
(Homo
sapiens) 		4 / 8 LEU A 240
LYS A 243
ILE A 257
THR A 259
 None
 0.84A 5ljbA-2rhzA:
undetectable		 5ljbA-2rhzA:
16.04