SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ri0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Streptococcus
mutans) 		4 / 8 THR A  38
GLY A 124
GLY A 191
PHE A 190
 None
 0.70A 1d0vA-2ri0A:
undetectable		 1d0vA-2ri0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Streptococcus
mutans) 		4 / 8 THR A  38
GLY A 124
GLY A 191
PHE A 190
 None
 0.71A 1jhqA-2ri0A:
undetectable		 1jhqA-2ri0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Streptococcus
mutans) 		4 / 8 THR A  38
GLY A 124
GLY A 191
PHE A 190
 None
 0.70A 1jhvA-2ri0A:
undetectable		 1jhvA-2ri0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Streptococcus
mutans) 		4 / 6 LEU A  42
TYR A  43
ILE A  46
GLY A  32
 None
 0.93A 2du8A-2ri0A:
undetectable		 2du8A-2ri0A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Streptococcus
mutans) 		4 / 5 GLU A  63
PRO A  95
ILE A 172
GLY A  97
 None
 1.12A 2qeuA-2ri0A:
undetectable
2qeuC-2ri0A:
undetectable		 2qeuA-2ri0A:
21.37
2qeuC-2ri0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Streptococcus
mutans) 		4 / 7 ILE A  46
LEU A  51
MET A  56
THR A  30
 None
 1.02A 3ag2N-2ri0A:
undetectable
3ag2W-2ri0A:
undetectable		 3ag2N-2ri0A:
17.89
3ag2W-2ri0A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Streptococcus
mutans) 		4 / 4 GLU A 135
GLY A 137
THR A 138
GLU A 208
 None
 0.87A 3e9xA-2ri0A:
undetectable		 3e9xA-2ri0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Streptococcus
mutans) 		4 / 6 ILE A  46
LEU A  51
MET A  56
THR A  30
 None
 1.00A 3wg7A-2ri0A:
undetectable
3wg7J-2ri0A:
undetectable		 3wg7A-2ri0A:
17.89
3wg7J-2ri0A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Streptococcus
mutans) 		5 / 12 LEU A  61
LEU A 187
LEU A 223
ALA A 229
PHE A 190
 None
 1.36A 4rtbA-2ri0A:
undetectable		 4rtbA-2ri0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Streptococcus
mutans) 		4 / 7 GLU A  22
LEU A  20
LEU A 120
LEU A  31
 None
 0.78A 4wg0B-2ri0A:
undetectable
4wg0C-2ri0A:
undetectable		 4wg0B-2ri0A:
3.51
4wg0C-2ri0A:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Streptococcus
mutans) 		4 / 7 LEU A 120
LEU A  31
GLU A  22
LEU A  20
 None
 0.73A 4wg0L-2ri0A:
undetectable
4wg0M-2ri0A:
undetectable		 4wg0L-2ri0A:
3.51
4wg0M-2ri0A:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Streptococcus
mutans) 		3 / 3 LEU A 149
TYR A  75
SER A 173
 None
 0.85A 5iktA-2ri0A:
undetectable		 5iktA-2ri0A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Streptococcus
mutans) 		3 / 3 LEU A  40
ASP A 226
ILE A 224
 None
 0.62A 6dh0B-2ri0A:
undetectable		 6dh0B-2ri0A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Streptococcus
mutans) 		5 / 9 PRO A 211
VAL A 206
SER A 141
LEU A 176
ILE A 214
 None
 1.11A 6fdyU-2ri0A:
undetectable		 6fdyU-2ri0A:
21.43