SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ri6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 11 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
 None
 0.83A 1hxwB-2ri6A:
undetectable		 1hxwB-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 11 GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.91A 1ohrA-2ri6A:
undetectable		 1ohrA-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.75A 1rl8B-2ri6A:
undetectable		 1rl8B-2ri6A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 9 ALA A 112
ASN A 111
GLY A  43
PHE A  74
GLY A  47
 MLI  A   2 (-3.2A)
None
MLI  A   2 (-3.5A)
None
None
 1.48A 1ru9H-2ri6A:
0.0
1ru9L-2ri6A:
0.0		 1ru9H-2ri6A:
19.80
1ru9L-2ri6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 10 ALA A 112
ASN A 111
GLY A  43
PHE A  74
GLY A  47
 MLI  A   2 (-3.2A)
None
MLI  A   2 (-3.5A)
None
None
 1.46A 1ruaH-2ri6A:
undetectable
1ruaL-2ri6A:
undetectable		 1ruaH-2ri6A:
19.80
1ruaL-2ri6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 7 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.78A 1usqA-2ri6A:
undetectable		 1usqA-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 6 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.78A 1usqB-2ri6A:
undetectable		 1usqB-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 6 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.79A 1usqC-2ri6A:
undetectable		 1usqC-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 6 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.78A 1usqD-2ri6A:
undetectable		 1usqD-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 6 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.76A 1usqE-2ri6A:
undetectable		 1usqE-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 7 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.77A 1usqF-2ri6A:
undetectable		 1usqF-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 10 GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.96A 2aquA-2ri6A:
undetectable		 2aquA-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.85A 2avvA-2ri6A:
undetectable		 2avvA-2ri6A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.83A 2bpxB-2ri6A:
undetectable		 2bpxB-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.82A 2f80B-2ri6A:
undetectable		 2f80B-2ri6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.92A 2f81B-2ri6A:
undetectable		 2f81B-2ri6A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A  56
VAL A 279
 None
 1.10A 2f8gB-2ri6A:
undetectable		 2f8gB-2ri6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.96A 2f8gB-2ri6A:
undetectable		 2f8gB-2ri6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 11 GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.83A 2fxeB-2ri6A:
undetectable		 2fxeB-2ri6A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 7 SER A   8
SER A  10
THR A   9
ASN A  28
 None
 1.03A 2i91A-2ri6A:
4.1		 2i91A-2ri6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 7 SER A   8
SER A  10
THR A   9
ASN A  28
 None
 1.03A 2i91B-2ri6A:
3.9		 2i91B-2ri6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 9 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.93A 2idwB-2ri6A:
undetectable		 2idwB-2ri6A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.90A 2ienA-2ri6A:
undetectable		 2ienA-2ri6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.89A 2ienB-2ri6A:
undetectable		 2ienB-2ri6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 6 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.78A 2jkjA-2ri6A:
undetectable		 2jkjA-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 6 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.79A 2jkjB-2ri6A:
undetectable		 2jkjB-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 6 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.79A 2jkjC-2ri6A:
undetectable		 2jkjC-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 7 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.77A 2jkjE-2ri6A:
undetectable		 2jkjE-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 7 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.78A 2jklA-2ri6A:
undetectable		 2jklA-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 6 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.77A 2jklB-2ri6A:
undetectable		 2jklB-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 7 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.79A 2jklC-2ri6A:
undetectable		 2jklC-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 7 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.77A 2jklE-2ri6A:
undetectable		 2jklE-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 7 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.78A 2jklF-2ri6A:
undetectable		 2jklF-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.85A 2nmzA-2ri6A:
undetectable		 2nmzA-2ri6A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.84A 2nmzB-2ri6A:
undetectable		 2nmzB-2ri6A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.86A 2o4kB-2ri6A:
undetectable		 2o4kB-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
ALA A  62
GLY A  57
VAL A  56
ILE A 280
 None
 1.00A 2o4lA-2ri6A:
undetectable		 2o4lA-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		7 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A  56
VAL A 279
ILE A 280
 None
 1.05A 2o4lB-2ri6A:
undetectable		 2o4lB-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 ASP A 254
ASP A 253
ILE A 225
ILE A 252
ILE A 133
 None
 0.95A 2o4nA-2ri6A:
undetectable		 2o4nA-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 9 LEU A 283
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.92A 2o4pB-2ri6A:
undetectable		 2o4pB-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.97A 2q63A-2ri6A:
undetectable		 2q63A-2ri6A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.88A 2q64B-2ri6A:
undetectable		 2q64B-2ri6A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.75A 2qakA-2ri6A:
undetectable		 2qakA-2ri6A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.81A 2r5pB-2ri6A:
undetectable		 2r5pB-2ri6A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.80A 2r5pD-2ri6A:
undetectable		 2r5pD-2ri6A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 11 GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.87A 2r5qB-2ri6A:
undetectable		 2r5qB-2ri6A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		3 / 3 PHE A  74
SER A 207
LEU A 205
 None
 0.77A 2w1bA-2ri6A:
undetectable		 2w1bA-2ri6A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.85A 3bvbA-2ri6A:
undetectable		 3bvbA-2ri6A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.91A 3bvbB-2ri6A:
undetectable		 3bvbB-2ri6A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.82A 3cywA-2ri6A:
undetectable		 3cywA-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
GLY A  57
VAL A 279
ILE A 280
 None
 0.85A 3cywA-2ri6A:
undetectable		 3cywA-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.85A 3cywB-2ri6A:
undetectable		 3cywB-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.80A 3d1xB-2ri6A:
undetectable		 3d1xB-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.86A 3d1yA-2ri6A:
undetectable		 3d1yA-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.85A 3d20B-2ri6A:
undetectable		 3d20B-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 10 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.86A 3ekpD-2ri6A:
undetectable		 3ekpD-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 11 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.90A 3ektC-2ri6A:
undetectable		 3ektC-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 10 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.88A 3ekvA-2ri6A:
undetectable		 3ekvA-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 10 GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.94A 3ekyA-2ri6A:
undetectable		 3ekyA-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 10 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.92A 3em3A-2ri6A:
undetectable		 3em3A-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 10 LEU A 283
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.98A 3em3B-2ri6A:
undetectable		 3em3B-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 11 GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.94A 3em4A-2ri6A:
undetectable		 3em4A-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.85A 3jw2A-2ri6A:
undetectable		 3jw2A-2ri6A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 1.00A 3jw2B-2ri6A:
undetectable		 3jw2B-2ri6A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.90A 3k4vA-2ri6A:
undetectable		 3k4vA-2ri6A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.90A 3k4vB-2ri6A:
undetectable		 3k4vB-2ri6A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.97A 3k4vD-2ri6A:
undetectable		 3k4vD-2ri6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.85A 3k4vD-2ri6A:
undetectable		 3k4vD-2ri6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 245
ASP A 243
PRO A 241
LEU A 222
ILE A 252
 None
 0.93A 3ku1H-2ri6A:
undetectable		 3ku1H-2ri6A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.82A 3lzsA-2ri6A:
undetectable		 3lzsA-2ri6A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.87A 3lzsB-2ri6A:
undetectable		 3lzsB-2ri6A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.85A 3lzuA-2ri6A:
undetectable		 3lzuA-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.95A 3lzuB-2ri6A:
undetectable		 3lzuB-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.93A 3ndtA-2ri6A:
undetectable		 3ndtA-2ri6A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.91A 3ndtB-2ri6A:
undetectable		 3ndtB-2ri6A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.80A 3nduB-2ri6A:
undetectable		 3nduB-2ri6A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.97A 3nduD-2ri6A:
undetectable		 3nduD-2ri6A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.84A 3nduD-2ri6A:
undetectable		 3nduD-2ri6A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.83A 3nu3A-2ri6A:
undetectable		 3nu3A-2ri6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 11 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.70A 3nu3B-2ri6A:
undetectable		 3nu3B-2ri6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 9 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.74A 3nu4B-2ri6A:
undetectable		 3nu4B-2ri6A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.71A 3nu5B-2ri6A:
undetectable		 3nu5B-2ri6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 10 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.83A 3nu6B-2ri6A:
undetectable		 3nu6B-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 9 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.72A 3nujB-2ri6A:
undetectable		 3nujB-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 9 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.70A 3nuoB-2ri6A:
undetectable		 3nuoB-2ri6A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		7 / 9 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A  56
VAL A 279
ILE A 280
 None
 1.03A 3oxvA-2ri6A:
undetectable		 3oxvA-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 9 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A  56
ILE A 280
 None
 0.98A 3oxvC-2ri6A:
undetectable		 3oxvC-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 10 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A  56
VAL A 279
 None
 1.03A 3oxwA-2ri6A:
undetectable		 3oxwA-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 10 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A  56
VAL A 279
 None
 1.13A 3oxwC-2ri6A:
undetectable		 3oxwC-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 10 LEU A 283
ALA A  62
GLY A  57
VAL A  56
VAL A 279
ILE A 280
 None
 1.12A 3oxwD-2ri6A:
undetectable		 3oxwD-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.94A 3oxxC-2ri6A:
undetectable		 3oxxC-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 11 LEU A 283
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.95A 3oxxD-2ri6A:
undetectable		 3oxxD-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.80A 3pwmA-2ri6A:
undetectable		 3pwmA-2ri6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.85A 3pwrA-2ri6A:
undetectable		 3pwrA-2ri6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.80A 3pwrB-2ri6A:
undetectable		 3pwrB-2ri6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 10 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.75A 3s43B-2ri6A:
undetectable		 3s43B-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.84A 3s54A-2ri6A:
undetectable		 3s54A-2ri6A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.80A 3tkgA-2ri6A:
undetectable		 3tkgA-2ri6A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.83A 3tkgB-2ri6A:
undetectable		 3tkgB-2ri6A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.88A 3tkwA-2ri6A:
undetectable		 3tkwA-2ri6A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.90A 3tkwB-2ri6A:
undetectable		 3tkwB-2ri6A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.92A 3tl9A-2ri6A:
undetectable		 3tl9A-2ri6A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.96A 3tl9B-2ri6A:
undetectable		 3tl9B-2ri6A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 5 ILE A 182
TRP A 269
TRP A 266
PHE A 239
 None
 1.27A 3topB-2ri6A:
undetectable		 3topB-2ri6A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 THR A 219
ASN A 251
ALA A 112
GLY A 138
ASN A 111
 None
None
MLI  A   2 (-3.2A)
None
None
 0.91A 3v3oA-2ri6A:
undetectable		 3v3oA-2ri6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 5 TRP A 216
GLY A  41
ALA A 112
PHE A 157
 None
MLI  A   2 (-3.5A)
MLI  A   2 (-3.2A)
None
 1.45A 3wqwA-2ri6A:
undetectable		 3wqwA-2ri6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 10 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 1.06A 4dqfB-2ri6A:
undetectable		 4dqfB-2ri6A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.77A 4hlaA-2ri6A:
undetectable		 4hlaA-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 11 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
 None
 0.78A 4hlaB-2ri6A:
undetectable		 4hlaB-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.89A 4jecA-2ri6A:
undetectable		 4jecA-2ri6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		3 / 3 GLU A 270
TRP A 269
LYS A 262
 None
 1.50A 4k7aA-2ri6A:
undetectable		 4k7aA-2ri6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 10 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.89A 4ll3B-2ri6A:
undetectable		 4ll3B-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 10 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.87A 4ll3A-2ri6A:
undetectable		 4ll3A-2ri6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  19
MET A  82
LEU A  88
ILE A  25
PHE A  23
 None
 1.33A 4p6xG-2ri6A:
undetectable		 4p6xG-2ri6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  19
MET A  82
LEU A  88
ILE A  25
PHE A  23
 None
 1.30A 4p6xI-2ri6A:
undetectable		 4p6xI-2ri6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 11 GLY A  42
GLY A  43
GLY A 139
ILE A 153
PHE A 239
 MLI  A   2 (-3.5A)
MLI  A   2 (-3.5A)
None
None
None
 1.10A 4qoiA-2ri6A:
2.6
4qoiB-2ri6A:
4.1		 4qoiA-2ri6A:
21.93
4qoiB-2ri6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 9 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.72A 4rvjB-2ri6A:
undetectable		 4rvjB-2ri6A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 9 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.72A 4rvjD-2ri6A:
undetectable		 4rvjD-2ri6A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 8 LEU A 222
LEU A 132
ALA A 118
LEU A 134
LEU A 248
 None
 1.12A 4z90A-2ri6A:
undetectable
4z90B-2ri6A:
undetectable
4z90C-2ri6A:
undetectable
4z90D-2ri6A:
undetectable
4z90E-2ri6A:
undetectable		 4z90A-2ri6A:
21.66
4z90B-2ri6A:
21.66
4z90C-2ri6A:
21.66
4z90D-2ri6A:
21.66
4z90E-2ri6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 9 ALA A 122
LEU A 132
ALA A 118
LEU A 134
LEU A 248
LEU A 222
 None
 1.15A 4z91F-2ri6A:
undetectable
4z91G-2ri6A:
undetectable
4z91H-2ri6A:
undetectable
4z91I-2ri6A:
undetectable
4z91J-2ri6A:
undetectable		 4z91F-2ri6A:
21.66
4z91G-2ri6A:
21.66
4z91H-2ri6A:
21.66
4z91I-2ri6A:
21.66
4z91J-2ri6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 9 LEU A 132
ALA A 118
LEU A 134
LEU A 248
LEU A 222
ALA A 122
 None
 1.14A 4z91F-2ri6A:
undetectable
4z91G-2ri6A:
undetectable
4z91H-2ri6A:
undetectable
4z91I-2ri6A:
undetectable
4z91J-2ri6A:
undetectable		 4z91F-2ri6A:
21.66
4z91G-2ri6A:
21.66
4z91H-2ri6A:
21.66
4z91I-2ri6A:
21.66
4z91J-2ri6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 9 LEU A 222
ALA A 122
LEU A 132
ALA A 118
LEU A 134
LEU A 248
 None
 1.17A 4z91F-2ri6A:
undetectable
4z91G-2ri6A:
undetectable
4z91H-2ri6A:
undetectable
4z91I-2ri6A:
undetectable
4z91J-2ri6A:
undetectable		 4z91F-2ri6A:
21.66
4z91G-2ri6A:
21.66
4z91H-2ri6A:
21.66
4z91I-2ri6A:
21.66
4z91J-2ri6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		3 / 3 ASN A  51
ALA A  46
ARG A 190
 None
MLI  A   2 ( 4.6A)
MLI  A   2 ( 4.8A)
 0.72A 5cvtB-2ri6A:
4.1		 5cvtB-2ri6A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 101
GLY A  96
VAL A  13
PHE A 121
GLY A 110
 None
 0.99A 5f9zA-2ri6A:
2.4		 5f9zA-2ri6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 101
GLY A  96
VAL A  13
PHE A 121
GLY A 114
 None
 1.04A 5f9zA-2ri6A:
2.4		 5f9zA-2ri6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 6 PHE A  59
VAL A  36
MET A 135
ILE A 133
 None
 1.05A 5iwuA-2ri6A:
undetectable		 5iwuA-2ri6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 11 ALA A 116
THR A 117
ALA A 118
GLY A  42
GLY A  41
ALA A 112
 None
None
None
MLI  A   2 (-3.5A)
MLI  A   2 (-3.5A)
MLI  A   2 (-3.2A)
 1.41A 5lf7K-2ri6A:
undetectable
5lf7L-2ri6A:
undetectable		 5lf7K-2ri6A:
21.55
5lf7L-2ri6A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 11 ALA A 116
THR A 117
ALA A 118
GLY A  42
GLY A  41
ALA A 112
 None
None
None
MLI  A   2 (-3.5A)
MLI  A   2 (-3.5A)
MLI  A   2 (-3.2A)
 1.41A 5lf7Y-2ri6A:
undetectable
5lf7Z-2ri6A:
undetectable		 5lf7Y-2ri6A:
21.55
5lf7Z-2ri6A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 138
HIS A 244
ASN A 251
THR A 219
LEU A 222
 None
 1.30A 5lsuA-2ri6A:
undetectable		 5lsuA-2ri6A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 6 PHE A 275
THR A 232
ASP A 237
GLY A 264
 None
 1.09A 5mraA-2ri6A:
undetectable
5mraB-2ri6A:
undetectable		 5mraA-2ri6A:
21.13
5mraB-2ri6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		4 / 5 ASN A  75
VAL A  56
LEU A   4
SER A  10
 None
 1.23A 6a7pA-2ri6A:
undetectable		 6a7pA-2ri6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 7 GLY A 115
GLY A 114
GLY A  41
GLY A  43
GLY A  42
 None
None
MLI  A   2 (-3.5A)
MLI  A   2 (-3.5A)
MLI  A   2 (-3.5A)
 1.04A 6ag0A-2ri6A:
undetectable		 6ag0A-2ri6A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		3 / 3 PHE A  23
ASP A  22
LYS A  14
 None
 0.70A 6awtD-2ri6A:
undetectable		 6awtD-2ri6A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
ILE A 280
 None
 0.79A 6difB-2ri6A:
undetectable		 6difB-2ri6A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 283
GLY A  63
GLY A  57
VAL A 279
ILE A 280
 None
 0.87A 6difB-2ri6A:
undetectable		 6difB-2ri6A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE
(Paraburkholderia
xenovorans) 		6 / 12 LEU A 283
GLY A  63
ALA A  62
GLY A  57
VAL A 279
ILE A 280
 None
 0.97A 6dilB-2ri6A:
undetectable		 6dilB-2ri6A:
15.79