SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2rif CONSERVED PROTEIN
WITH 2 CBS DOMAINS
(Pyrobaculum
aerophilum) 		4 / 5 ASP A 118
LEU A 129
ALA A  89
LEU A 114
 AMP  A 201 (-2.4A)
None
None
None
 1.13A 1nh8A-2rifA:
undetectable		 1nh8A-2rifA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2rif CONSERVED PROTEIN
WITH 2 CBS DOMAINS
(Pyrobaculum
aerophilum) 		3 / 3 VAL A  50
VAL A  48
ASP A  82
 AMP  A 301 ( 4.9A)
None
None
 0.74A 2fumD-2rifA:
undetectable		 2fumD-2rifA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 2rif CONSERVED PROTEIN
WITH 2 CBS DOMAINS
(Pyrobaculum
aerophilum) 		4 / 7 VAL A 103
THR A  83
ARG A   3
LYS A   2
 None
 1.03A 2kotA-2rifA:
undetectable		 2kotA-2rifA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2rif CONSERVED PROTEIN
WITH 2 CBS DOMAINS
(Pyrobaculum
aerophilum) 		4 / 7 VAL A  86
VAL A 103
ASP A  82
VAL A  80
 None
 1.01A 2qbnA-2rifA:
undetectable		 2qbnA-2rifA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2rif CONSERVED PROTEIN
WITH 2 CBS DOMAINS
(Pyrobaculum
aerophilum) 		5 / 12 ASP A  55
ILE A  78
ASN A  97
ILE A  98
VAL A 101
 AMP  A 301 (-2.7A)
AMP  A 301 (-3.6A)
None
AMP  A 301 (-3.8A)
AMP  A 301 ( 4.5A)
 0.70A 3kpdC-2rifA:
17.9		 3kpdC-2rifA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2rif CONSERVED PROTEIN
WITH 2 CBS DOMAINS
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 116
LEU A  35
ILE A  78
PRO A  77
ASN A  75
 None
AMP  A 301 ( 4.6A)
AMP  A 301 (-3.6A)
None
AMP  A 301 ( 3.8A)
 1.25A 4gh8B-2rifA:
undetectable		 4gh8B-2rifA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 2rif CONSERVED PROTEIN
WITH 2 CBS DOMAINS
(Pyrobaculum
aerophilum) 		3 / 3 GLU A  53
LEU A  57
ARG A  58
 None
None
AMP  A 301 (-3.6A)
 0.69A 6d8fA-2rifA:
undetectable		 6d8fA-2rifA:
11.94