SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2rir DIPICOLINATE
SYNTHASE, A CHAIN
(Bacillus
subtilis) 		5 / 12 ILE A 224
MET A 233
VAL A 229
LEU A 230
ALA A 158
 None
 0.86A 1epbA-2rirA:
undetectable		 1epbA-2rirA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2rir DIPICOLINATE
SYNTHASE, A CHAIN
(Bacillus
subtilis) 		5 / 11 LEU A  17
GLY A  12
GLY A  11
VAL A  83
LEU A  38
 None
 1.15A 1mx1A-2rirA:
undetectable		 1mx1A-2rirA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2rir DIPICOLINATE
SYNTHASE, A CHAIN
(Bacillus
subtilis) 		4 / 7 LEU A 263
PHE A 251
LEU A 225
PRO A 246
 None
 0.85A 2vq5B-2rirA:
undetectable		 2vq5B-2rirA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2rir DIPICOLINATE
SYNTHASE, A CHAIN
(Bacillus
subtilis) 		4 / 8 LEU A  85
ILE A  10
PHE A  35
GLY A  12
 None
 0.93A 3b9lA-2rirA:
undetectable		 3b9lA-2rirA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_B_TESB340_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2rir DIPICOLINATE
SYNTHASE, A CHAIN
(Bacillus
subtilis) 		5 / 10 ILE A  30
THR A  76
SER A  79
VAL A  83
VAL A  74
 None
 1.41A 3burB-2rirA:
undetectable		 3burB-2rirA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 2rir DIPICOLINATE
SYNTHASE, A CHAIN
(Bacillus
subtilis) 		5 / 12 GLY A 177
ALA A 178
ILE A 215
VAL A 159
VAL A 157
 None
 1.05A 3ucbA-2rirA:
undetectable		 3ucbA-2rirA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2rir DIPICOLINATE
SYNTHASE, A CHAIN
(Bacillus
subtilis) 		5 / 6 TYR A 107
VAL A  74
VAL A  83
ILE A  50
LEU A  90
 None
 1.48A 4l1wB-2rirA:
undetectable		 4l1wB-2rirA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2rir DIPICOLINATE
SYNTHASE, A CHAIN
(Bacillus
subtilis) 		4 / 8 VAL A 210
LEU A 206
ASP A 241
ILE A 239
 None
 0.85A 4lzrA-2rirA:
undetectable		 4lzrA-2rirA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2rir DIPICOLINATE
SYNTHASE, A CHAIN
(Bacillus
subtilis) 		4 / 6 LEU A 198
VAL A 182
LEU A 162
VAL A 159
 None
 0.91A 5x7zA-2rirA:
undetectable		 5x7zA-2rirA:
20.81