SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rjb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		3 / 3 GLU A 139
GLU A 207
LEU A 131
 None
 0.74A 1v8bA-2rjbA:
undetectable		 1v8bA-2rjbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		5 / 12 SER A 129
SER A 108
TYR A  97
ALA A  70
VAL A 391
 None
None
None
ZN  A 501 ( 4.5A)
None
 1.13A 1vpoH-2rjbA:
undetectable
1vpoL-2rjbA:
undetectable		 1vpoH-2rjbA:
18.49
1vpoL-2rjbA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		4 / 8 PHE A 333
THR A 299
VAL A 296
ILE A 260
 None
 0.96A 2qbmA-2rjbA:
undetectable		 2qbmA-2rjbA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		4 / 5 GLU A 245
PRO A 240
ILE A 244
GLY A 243
 None
 1.11A 2qeuA-2rjbA:
undetectable
2qeuC-2rjbA:
undetectable		 2qeuA-2rjbA:
13.87
2qeuC-2rjbA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		3 / 3 MET A  54
GLU A 337
ASP A 335
 None
 1.12A 3a25A-2rjbA:
undetectable		 3a25A-2rjbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		3 / 3 TYR A  29
GLU A 292
ASP A 387
 None
 0.81A 3bxoA-2rjbA:
undetectable		 3bxoA-2rjbA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		3 / 3 TYR A  29
GLU A 292
ASP A 387
 None
 0.86A 3bxoB-2rjbA:
undetectable		 3bxoB-2rjbA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		4 / 5 PRO A 259
ILE A 260
PRO A 253
TYR A 385
 None
 0.96A 3d9lA-2rjbA:
undetectable
3d9lY-2rjbA:
undetectable		 3d9lA-2rjbA:
16.70
3d9lY-2rjbA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		3 / 3 GLU A 272
LEU A 270
LEU A 225
 None
 0.71A 3ohtA-2rjbA:
undetectable		 3ohtA-2rjbA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		3 / 3 GLU A 272
LEU A 270
LEU A 225
 None
 0.73A 3ohtB-2rjbA:
undetectable		 3ohtB-2rjbA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		4 / 8 ALA A  42
VAL A  39
ASP A  38
LEU A  35
 None
 0.80A 3roxA-2rjbA:
undetectable		 3roxA-2rjbA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		4 / 4 ASP A 307
ASP A 308
GLY A 302
THR A 332
 None
 1.07A 3tl9B-2rjbA:
undetectable		 3tl9B-2rjbA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		5 / 12 ILE A 211
VAL A 215
LEU A 204
ALA A 146
LEU A 131
 None
 1.29A 4m11C-2rjbA:
undetectable		 4m11C-2rjbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		5 / 11 LEU A 261
ARG A 256
LEU A 310
LEU A 298
LEU A 389
 None
 1.23A 4or0B-2rjbA:
undetectable		 4or0B-2rjbA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		4 / 6 PHE A 388
TYR A 385
LEU A 262
THR A 226
 None
None
None
ZN  A 501 ( 4.9A)
 0.96A 4paeA-2rjbA:
undetectable		 4paeA-2rjbA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		3 / 3 THR A 384
ASN A 122
PHE A 124
 None
 0.77A 4pd9A-2rjbA:
undetectable		 4pd9A-2rjbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		4 / 6 ALA A 145
GLY A  74
ILE A 136
VAL A 106
 None
 0.83A 4r21A-2rjbA:
undetectable		 4r21A-2rjbA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		4 / 5 GLU A 164
GLU A 167
TYR A 166
GLU A 165
 None
 1.49A 4r87E-2rjbA:
undetectable		 4r87E-2rjbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		5 / 12 GLU A 292
ARG A 294
PRO A 123
SER A  19
ARG A  62
 None
 1.36A 4uroA-2rjbA:
undetectable		 4uroA-2rjbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		5 / 12 GLU A 292
ARG A 294
PRO A 123
SER A  19
ARG A  62
 None
 1.34A 4uroB-2rjbA:
undetectable		 4uroB-2rjbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		5 / 12 GLU A 271
GLU A  25
PHE A 288
ALA A 212
HIS A 205
 None
 1.14A 4wcxC-2rjbA:
undetectable		 4wcxC-2rjbA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		5 / 12 GLU A 271
GLU A  25
PHE A 288
LEU A 210
HIS A 205
 None
 1.08A 4wcxC-2rjbA:
undetectable		 4wcxC-2rjbA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		5 / 12 LEU A 261
TYR A 433
LEU A 119
PHE A 388
ALA A 110
 None
 1.31A 5ieoA-2rjbA:
undetectable		 5ieoA-2rjbA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		5 / 12 LEU A  32
VAL A  36
PRO A 227
THR A 226
GLU A 290
 None
None
None
ZN  A 501 ( 4.9A)
ZN  A 501 (-2.6A)
 1.38A 5xipD-2rjbA:
undetectable		 5xipD-2rjbA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		4 / 7 ALA A 203
THR A 200
TYR A 201
PRO A 105
 None
 0.94A 6cduA-2rjbA:
undetectable
6cduE-2rjbA:
undetectable		 6cduA-2rjbA:
21.55
6cduE-2rjbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		4 / 7 PRO A 105
ALA A 203
THR A 200
TYR A 201
 None
 0.94A 6cduH-2rjbA:
undetectable
6cduI-2rjbA:
undetectable		 6cduH-2rjbA:
21.55
6cduI-2rjbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2rjb UNCHARACTERIZED
PROTEIN
(Shigella
flexneri) 		5 / 9 ALA A  70
GLY A  69
LEU A 225
CYH A 220
ARG A  72
 ZN  A 501 ( 4.5A)
None
None
None
None
 1.27A 6nm4B-2rjbA:
undetectable		 6nm4B-2rjbA:
17.92