SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rjo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ALZ_B_DVAB8_0
(ILE-GRAMICIDIN C
VAL-GRAMICIDIN A)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		4 / 5 VAL A 262
TRP A 225
VAL A 175
TRP A 237
 None
 1.39A 1alzA-2rjoA:
undetectable
1alzB-2rjoA:
undetectable		 1alzA-2rjoA:
3.54
1alzB-2rjoA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		4 / 7 ASN A 131
TRP A 130
TYR A  55
ARG A  48
 GAL  A 368 (-3.7A)
GAL  A 368 ( 4.0A)
SO4  A 370 ( 4.2A)
GAL  A 368 ( 3.0A)
 1.25A 1f9gA-2rjoA:
undetectable		 1f9gA-2rjoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		4 / 7 ASN A 131
TRP A 130
TYR A  55
ASN A 183
 GAL  A 368 (-3.7A)
GAL  A 368 ( 4.0A)
SO4  A 370 ( 4.2A)
GAL  A 368 (-4.3A)
 1.47A 1f9gA-2rjoA:
undetectable		 1f9gA-2rjoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 12 THR A  41
GLU A 304
GLY A 299
ILE A 294
ALA A 343
 None
 1.18A 1oltA-2rjoA:
undetectable		 1oltA-2rjoA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		4 / 8 PHE A  65
LEU A 348
THR A 127
VAL A 101
 None
 1.16A 1uyuB-2rjoA:
undetectable		 1uyuB-2rjoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		4 / 4 GLY A 295
SER A 297
VAL A 146
LEU A 149
 None
 1.14A 1yajB-2rjoA:
3.5		 1yajB-2rjoA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 11 ILE A 275
LEU A 280
GLY A 246
ALA A 247
VAL A 262
 None
 0.91A 2fxdA-2rjoA:
undetectable		 2fxdA-2rjoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		4 / 7 ASP A 287
ALA A 350
PHE A 289
PRO A 341
 SO4  A 372 (-3.5A)
None
None
SO4  A 372 ( 4.4A)
 1.06A 2q6oA-2rjoA:
5.5		 2q6oA-2rjoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 12 ALA A  44
LEU A  92
LEU A  93
ILE A  86
GLY A  85
 None
 1.02A 2yjaB-2rjoA:
undetectable		 2yjaB-2rjoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 12 GLY A 192
ALA A 196
LEU A 197
VAL A 210
PHE A 208
 None
 1.07A 2zulA-2rjoA:
3.2		 2zulA-2rjoA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 12 ALA A  44
LEU A  92
LEU A  93
ILE A  86
GLY A  85
 None
 0.99A 3q95A-2rjoA:
undetectable		 3q95A-2rjoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		3 / 3 TYR A  55
ARG A  48
SER A  49
 SO4  A 370 ( 4.2A)
GAL  A 368 ( 3.0A)
SO4  A 370 (-3.1A)
 1.11A 4dr2I-2rjoA:
1.3
4dr2J-2rjoA:
undetectable		 4dr2I-2rjoA:
18.35
4dr2J-2rjoA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		4 / 7 LEU A 309
ALA A 147
LEU A 312
SER A 319
 None
 1.01A 4ikjA-2rjoA:
undetectable
4ikjB-2rjoA:
undetectable		 4ikjA-2rjoA:
18.21
4ikjB-2rjoA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		4 / 7 SER A 319
LEU A 309
ALA A 147
LEU A 312
 None
 1.03A 4ikkA-2rjoA:
undetectable
4ikkB-2rjoA:
undetectable		 4ikkA-2rjoA:
18.21
4ikkB-2rjoA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		3 / 3 ASN A 131
ASP A 105
ASP A 266
 GAL  A 368 (-3.7A)
GAL  A 368 (-2.9A)
GAL  A 368 (-2.9A)
 0.74A 4obwD-2rjoA:
undetectable		 4obwD-2rjoA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 9 ALA A 238
THR A 263
ALA A 244
GLY A 157
ASP A 266
 None
None
None
None
GAL  A 368 (-2.9A)
 1.11A 4qwuK-2rjoA:
undetectable
4qwuL-2rjoA:
undetectable		 4qwuK-2rjoA:
20.37
4qwuL-2rjoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 9 ALA A 238
THR A 263
ALA A 244
GLY A 157
ASP A 266
 None
None
None
None
GAL  A 368 (-2.9A)
 1.09A 4qwuY-2rjoA:
undetectable
4qwuZ-2rjoA:
undetectable		 4qwuY-2rjoA:
20.37
4qwuZ-2rjoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 12 LEU A 348
LEU A  43
ALA A  62
GLY A 295
GLY A 292
 None
 0.95A 4rn6B-2rjoA:
undetectable		 4rn6B-2rjoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 12 LEU A 149
LEU A 348
VAL A 146
ALA A 147
ILE A 307
 None
 0.88A 4x1yD-2rjoA:
3.4		 4x1yD-2rjoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 11 ALA A  44
LEU A  92
LEU A  93
ILE A  86
GLY A  85
 None
 1.06A 5dxbB-2rjoA:
undetectable		 5dxbB-2rjoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 12 ALA A  44
LEU A  92
LEU A  93
ILE A  86
GLY A  85
 None
 1.05A 5gtrA-2rjoA:
undetectable		 5gtrA-2rjoA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 12 LEU A  93
LEU A 100
ALA A 124
LEU A 136
ILE A  89
 None
 1.04A 5ljeA-2rjoA:
undetectable		 5ljeA-2rjoA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		4 / 8 GLY A  80
ILE A 180
ASP A 108
ASP A 105
 None
None
None
GAL  A 368 (-2.9A)
 1.03A 5vlmH-2rjoA:
undetectable		 5vlmH-2rjoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 12 GLY A 292
GLY A  61
ASP A 105
ILE A 129
LEU A 291
 None
None
GAL  A 368 (-2.9A)
None
None
 1.13A 6b3aA-2rjoA:
2.2		 6b3aA-2rjoA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 12 GLY A 292
GLY A  61
ASP A 105
ILE A 129
LEU A 291
 None
None
GAL  A 368 (-2.9A)
None
None
 1.09A 6b3bA-2rjoA:
2.6		 6b3bA-2rjoA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		6 / 12 ILE A  86
GLY A  85
THR A  77
THR A  78
VAL A 126
ILE A 115
 None
 1.45A 6emuC-2rjoA:
4.1		 6emuC-2rjoA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		4 / 6 ARG A 252
ALA A 257
LEU A 251
ALA A 250
 None
 1.11A 6fosB-2rjoA:
undetectable		 6fosB-2rjoA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 10 LEU A 164
VAL A 281
VAL A 236
ILE A 248
ALA A 247
 None
 1.26A 6h1lA-2rjoA:
undetectable		 6h1lA-2rjoA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Paraburkholderia
phytofirmans) 		5 / 11 LEU A 164
VAL A 281
VAL A 236
ILE A 248
ALA A 247
 None
 1.27A 6h1lB-2rjoA:
undetectable		 6h1lB-2rjoA:
20.89