SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rjq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.96A 1dhiA-2rjqA:
undetectable		 1dhiA-2rjqA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 11 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.92A 1dhiB-2rjqA:
undetectable		 1dhiB-2rjqA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.96A 1dhjA-2rjqA:
undetectable		 1dhjA-2rjqA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.97A 1dhjB-2rjqA:
undetectable		 1dhjB-2rjqA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.94A 1draA-2rjqA:
undetectable		 1draA-2rjqA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.90A 1draB-2rjqA:
undetectable		 1draB-2rjqA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.97A 1drbA-2rjqA:
undetectable		 1drbA-2rjqA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.96A 1drbB-2rjqA:
undetectable		 1drbB-2rjqA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 5 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.17A 1os2A-2rjqA:
10.2		 1os2A-2rjqA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.16A 1os2D-2rjqA:
10.3		 1os2D-2rjqA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 7 HIS A 289
TYR A 491
LEU A 499
GLN A 495
 None
None
None
NAG  A 557 (-3.4A)
 1.04A 1qzrA-2rjqA:
undetectable		 1qzrA-2rjqA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 7 HIS A 289
TYR A 491
LEU A 499
GLN A 495
 None
None
None
NAG  A 557 (-3.4A)
 1.04A 1qzrB-2rjqA:
undetectable		 1qzrB-2rjqA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2rjq ADAMTS-5
(Homo
sapiens) 		6 / 10 THR A 378
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
 BAT  A 559 ( 4.1A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.46A 1r55A-2rjqA:
25.4		 1r55A-2rjqA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.92A 1ra2A-2rjqA:
undetectable		 1ra2A-2rjqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.98A 1ra3A-2rjqA:
undetectable		 1ra3A-2rjqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.92A 1ra8A-2rjqA:
undetectable		 1ra8A-2rjqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.94A 1rb2A-2rjqA:
undetectable		 1rb2A-2rjqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.96A 1rd7A-2rjqA:
undetectable		 1rd7A-2rjqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.98A 1rd7B-2rjqA:
undetectable		 1rd7B-2rjqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.89A 1re7B-2rjqA:
undetectable		 1re7B-2rjqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 1.01A 1rx2A-2rjqA:
undetectable		 1rx2A-2rjqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.19A 1uttA-2rjqA:
10.6		 1uttA-2rjqA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.19A 1utzA-2rjqA:
10.4		 1utzA-2rjqA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.20A 1utzB-2rjqA:
10.5		 1utzB-2rjqA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 361
GLY A 413
ILE A 387
LEU A 438
ILE A 307
 None
 0.88A 1x1aA-2rjqA:
undetectable		 1x1aA-2rjqA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 6 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.16A 1y93A-2rjqA:
10.5		 1y93A-2rjqA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.90A 2d0kA-2rjqA:
undetectable		 2d0kA-2rjqA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.83A 2d0kB-2rjqA:
undetectable		 2d0kB-2rjqA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.93A 2drcA-2rjqA:
undetectable		 2drcA-2rjqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.90A 2drcB-2rjqA:
undetectable		 2drcB-2rjqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 9 LEU A 418
ILE A 387
PHE A 463
LEU A 464
ILE A 460
 None
 1.27A 2f78B-2rjqA:
undetectable		 2f78B-2rjqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 9 LEU A 418
ILE A 387
PHE A 463
LEU A 464
ILE A 460
 None
 1.29A 2f7aA-2rjqA:
undetectable		 2f7aA-2rjqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.12A 2hu6A-2rjqA:
10.4		 2hu6A-2rjqA:
15.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_A_097A1001_1
(ADAMTS-1)		 2rjq ADAMTS-5
(Homo
sapiens) 		6 / 9 ASP A 377
LEU A 379
THR A 407
GLU A 411
HIS A 414
LEU A 443
 BAT  A 559 (-3.7A)
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
 1.01A 2jihA-2rjqA:
40.4		 2jihA-2rjqA:
48.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_A_097A1001_1
(ADAMTS-1)		 2rjq ADAMTS-5
(Homo
sapiens) 		7 / 9 LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
LEU A 443
 BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
 0.75A 2jihA-2rjqA:
40.4		 2jihA-2rjqA:
48.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_B_097B1001_1
(ADAMTS-1)		 2rjq ADAMTS-5
(Homo
sapiens) 		6 / 8 LEU A 379
HIS A 410
GLU A 411
HIS A 414
HIS A 420
LEU A 443
 BAT  A 559 (-4.0A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
 0.57A 2jihB-2rjqA:
40.2		 2jihB-2rjqA:
48.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_B_097B1001_1
(ADAMTS-1)		 2rjq ADAMTS-5
(Homo
sapiens) 		6 / 8 LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
 BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.26A 2jihB-2rjqA:
40.2		 2jihB-2rjqA:
48.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 6 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.19A 2ow9A-2rjqA:
10.0		 2ow9A-2rjqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.19A 2ow9B-2rjqA:
9.9		 2ow9B-2rjqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.22A 2ozrC-2rjqA:
9.6		 2ozrC-2rjqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.23A 2ozrD-2rjqA:
9.8		 2ozrD-2rjqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.25A 2ozrE-2rjqA:
10.0		 2ozrE-2rjqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		3 / 3 HIS A 410
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.23A 2ozrF-2rjqA:
9.9		 2ozrF-2rjqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.93A 3drcA-2rjqA:
undetectable		 3drcA-2rjqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.90A 3drcB-2rjqA:
undetectable		 3drcB-2rjqA:
17.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2rjq ADAMTS-5
(Homo
sapiens) 		6 / 9 ASP A 377
LEU A 379
THR A 407
GLU A 411
HIS A 414
HIS A 420
 BAT  A 559 (-3.7A)
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.69A 3hy7A-2rjqA:
36.9		 3hy7A-2rjqA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2rjq ADAMTS-5
(Homo
sapiens) 		7 / 9 LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
ILE A 442
 BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.3A)
 0.46A 3hy7A-2rjqA:
36.9		 3hy7A-2rjqA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2rjq ADAMTS-5
(Homo
sapiens) 		8 / 9 ASP A 377
LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
LEU A 443
 BAT  A 559 (-3.7A)
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
 0.75A 3hy7B-2rjqA:
35.7		 3hy7B-2rjqA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2rjq ADAMTS-5
(Homo
sapiens) 		8 / 9 LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
ILE A 442
LEU A 443
 BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.3A)
BAT  A 559 (-4.2A)
 0.64A 3hy7B-2rjqA:
35.7		 3hy7B-2rjqA:
99.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 5 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.18A 3kecA-2rjqA:
10.1		 3kecA-2rjqA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		3 / 3 HIS A 410
GLU A 411
HIS A 414
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
 0.17A 3kecB-2rjqA:
10.0		 3kecB-2rjqA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 5 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.15A 3likA-2rjqA:
10.5		 3likA-2rjqA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.17A 3lilA-2rjqA:
10.5		 3lilA-2rjqA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 5 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.18A 3ljgA-2rjqA:
10.7		 3ljgA-2rjqA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 5 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.17A 3lkaA-2rjqA:
10.4		 3lkaA-2rjqA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 7 LEU A 321
SER A 278
THR A 366
VAL A 396
 None
 1.01A 3ozkB-2rjqA:
undetectable		 3ozkB-2rjqA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 1.00A 3tq9A-2rjqA:
undetectable		 3tq9A-2rjqA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 11 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.96A 3tqbA-2rjqA:
undetectable		 3tqbA-2rjqA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 6 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.29A 4a7bA-2rjqA:
9.8		 4a7bA-2rjqA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.91A 4dfrB-2rjqA:
undetectable		 4dfrB-2rjqA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.93A 4ej1A-2rjqA:
undetectable		 4ej1A-2rjqA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.94A 4fhbA-2rjqA:
undetectable		 4fhbA-2rjqA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.93A 4i13A-2rjqA:
undetectable		 4i13A-2rjqA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 7 VAL A 396
ILE A 397
LEU A 287
LEU A 291
 None
 1.04A 4l1wA-2rjqA:
undetectable		 4l1wA-2rjqA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2rjq ADAMTS-5
(Homo
sapiens) 		3 / 3 HIS A 346
VAL A 319
LEU A 272
 None
 0.63A 4m2vA-2rjqA:
undetectable		 4m2vA-2rjqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 2rjq ADAMTS-5
(Homo
sapiens) 		3 / 3 PRO A 390
ASN A 349
HIS A 358
 None
 0.64A 4ma3H-2rjqA:
undetectable
4ma3L-2rjqA:
undetectable		 4ma3H-2rjqA:
23.10
4ma3L-2rjqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.94A 4nx6A-2rjqA:
undetectable		 4nx6A-2rjqA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.95A 4nx7A-2rjqA:
undetectable		 4nx7A-2rjqA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.95A 4p3rA-2rjqA:
undetectable		 4p3rA-2rjqA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 8 ALA A 295
GLY A 482
LEU A 292
LEU A 273
 None
 0.89A 4po0A-2rjqA:
undetectable		 4po0A-2rjqA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.91A 4pssA-2rjqA:
undetectable		 4pssA-2rjqA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 1.00A 4pstA-2rjqA:
undetectable		 4pstA-2rjqA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 LEU A 291
ILE A 363
LEU A 287
ASP A 276
SER A 278
 None
 1.42A 4r88A-2rjqA:
undetectable		 4r88A-2rjqA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 LEU A 291
ILE A 363
LEU A 287
ASP A 276
SER A 278
 None
 1.39A 4r88B-2rjqA:
undetectable		 4r88B-2rjqA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 LEU A 291
ILE A 363
LEU A 287
ASP A 276
SER A 278
 None
 1.41A 4r88C-2rjqA:
undetectable		 4r88C-2rjqA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 LEU A 291
ILE A 363
LEU A 287
ASP A 276
SER A 278
 None
 1.42A 4r88D-2rjqA:
undetectable		 4r88D-2rjqA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 LEU A 291
ILE A 363
LEU A 287
ASP A 276
SER A 278
 None
 1.38A 4r88E-2rjqA:
undetectable		 4r88E-2rjqA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 LEU A 291
ILE A 363
LEU A 287
ASP A 276
SER A 278
 None
 1.37A 4r88F-2rjqA:
undetectable		 4r88F-2rjqA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.92A 4x5gB-2rjqA:
undetectable		 4x5gB-2rjqA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.90A 5eajA-2rjqA:
undetectable		 5eajA-2rjqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 2rjq ADAMTS-5
(Homo
sapiens) 		3 / 3 ILE A 442
MET A 381
ASP A 377
 BAT  A 559 (-4.3A)
BAT  A 559 ( 3.7A)
BAT  A 559 (-3.7A)
 0.82A 5h2uA-2rjqA:
undetectable		 5h2uA-2rjqA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.16A 5n5jA-2rjqA:
10.5		 5n5jA-2rjqA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 5 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.15A 5n5kA-2rjqA:
10.6		 5n5kA-2rjqA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.92A 5ujxA-2rjqA:
undetectable		 5ujxA-2rjqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2rjq ADAMTS-5
(Homo
sapiens) 		3 / 3 HIS A 420
HIS A 414
HIS A 410
 ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.2A)
 0.73A 5w97a-2rjqA:
undetectable		 5w97a-2rjqA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2rjq ADAMTS-5
(Homo
sapiens) 		3 / 3 HIS A 420
HIS A 414
HIS A 410
 ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.2A)
 0.68A 5x1fN-2rjqA:
undetectable		 5x1fN-2rjqA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.93A 5z6jA-2rjqA:
undetectable		 5z6jA-2rjqA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		5 / 12 ALA A 298
LEU A 271
ILE A 387
LEU A 472
ILE A 311
 None
 0.96A 5z6kA-2rjqA:
undetectable		 5z6kA-2rjqA:
17.45