SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rjt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 LEU A  28
GLY A  18
SER A  15
GLY A 234
LEU A 338
 None
 1.14A 1fe2A-2rjtA:
undetectable		 1fe2A-2rjtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 11 HIS A 303
ASN A 310
SER A 165
ALA A 163
LEU A 339
 None
 1.47A 1hwkB-2rjtA:
undetectable		 1hwkB-2rjtA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 11 HIS A 303
ASN A 310
SER A 165
ALA A 163
LEU A 339
 None
 1.45A 1hwkA-2rjtA:
undetectable		 1hwkA-2rjtA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 11 HIS A 303
ASN A 310
SER A 165
ALA A 163
LEU A 339
 None
 1.45A 1hwkD-2rjtA:
undetectable		 1hwkD-2rjtA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 11 HIS A 303
ASN A 310
SER A 165
ALA A 163
LEU A 339
 None
 1.46A 1hwkC-2rjtA:
undetectable		 1hwkC-2rjtA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 11 ALA A 170
ALA A 401
LEU A 403
SER A 391
THR A 393
 None
 0.91A 1ictA-2rjtA:
undetectable
1ictC-2rjtA:
undetectable		 1ictA-2rjtA:
14.32
1ictC-2rjtA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		4 / 7 PRO A 360
VAL A 359
THR A 362
VAL A 349
 None
 0.78A 1jgsA-2rjtA:
undetectable		 1jgsA-2rjtA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		4 / 8 SER A 194
ILE A 112
GLY A 111
GLY A 234
 None
 0.72A 1me7A-2rjtA:
undetectable		 1me7A-2rjtA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 11 THR A 331
PHE A 334
SER A 333
PHE A 358
VAL A 377
 None
 1.26A 1q23L-2rjtA:
undetectable		 1q23L-2rjtA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		4 / 7 THR A 196
PRO A 197
GLY A 111
ASP A  72
 None
 0.90A 2ddwB-2rjtA:
undetectable		 2ddwB-2rjtA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 TYR A 260
SER A 165
ALA A 401
ALA A 344
GLY A 340
 None
 1.16A 2igtC-2rjtA:
undetectable		 2igtC-2rjtA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 GLY A 313
ASP A 265
GLY A 278
GLY A 276
LEU A 285
 None
 0.88A 2nxeA-2rjtA:
undetectable		 2nxeA-2rjtA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 GLY A 313
ASP A 265
GLY A 278
GLY A 276
LEU A 285
 None
 0.90A 2nxeB-2rjtA:
undetectable		 2nxeB-2rjtA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 ALA A 341
GLY A 110
LYS A 137
GLU A 114
ILE A 115
 None
 0.95A 2plwA-2rjtA:
undetectable		 2plwA-2rjtA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		4 / 7 LEU A 339
PHE A 229
ILE A 200
GLY A 108
 None
 0.88A 2v0mC-2rjtA:
undetectable		 2v0mC-2rjtA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 GLY A 259
ALA A 286
ASN A 392
SER A 167
GLY A 343
 None
 1.08A 2vmyA-2rjtA:
undetectable		 2vmyA-2rjtA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 TYR A 299
PHE A 358
ALA A 363
SER A 333
SER A 329
 None
 1.40A 3apwA-2rjtA:
undetectable		 3apwA-2rjtA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 TYR A 299
VAL A 349
ALA A 363
SER A 333
SER A 329
 None
 1.37A 3apwA-2rjtA:
undetectable		 3apwA-2rjtA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		4 / 6 ALA A 401
LEU A 403
SER A 391
THR A 393
 None
 0.90A 3d2tB-2rjtA:
undetectable		 3d2tB-2rjtA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		3 / 3 SER A 330
GLY A 304
SER A 219
 None
 0.57A 3loqA-2rjtA:
undetectable		 3loqA-2rjtA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 7 ALA A 341
SER A 235
VAL A  13
VAL A 345
LEU A 338
 None
 1.43A 3o14A-2rjtA:
undetectable		 3o14A-2rjtA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 ALA A 208
PHE A 229
ILE A 109
LEU A 339
GLY A 202
 None
 1.03A 3rukB-2rjtA:
undetectable		 3rukB-2rjtA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 GLY A 236
VAL A 239
GLY A 340
SER A 167
ASP A 173
 None
 0.93A 3sueC-2rjtA:
undetectable		 3sueC-2rjtA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 10 PHE A 151
VAL A 147
ALA A  81
THR A  14
PHE A  63
 None
 1.13A 3t3qA-2rjtA:
undetectable		 3t3qA-2rjtA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 LEU A 238
GLY A 340
LEU A 338
ALA A  78
SER A 235
 None
 1.13A 3tbgB-2rjtA:
undetectable		 3tbgB-2rjtA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 LEU A 238
GLY A 340
LEU A 338
ALA A  78
SER A 235
 None
 1.15A 3tbgD-2rjtA:
undetectable		 3tbgD-2rjtA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 THR A  14
PHE A  57
SER A 235
PHE A 151
PHE A  63
 None
 1.33A 3u9fG-2rjtA:
undetectable
3u9fH-2rjtA:
undetectable		 3u9fG-2rjtA:
18.18
3u9fH-2rjtA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		3 / 3 HIS A 337
GLU A 346
ASN A 168
 None
 1.00A 4bupB-2rjtA:
undetectable		 4bupB-2rjtA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		4 / 7 THR A 393
GLY A 343
ASN A 168
GLY A 108
 None
 0.83A 4forA-2rjtA:
undetectable		 4forA-2rjtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		4 / 7 ALA A 401
LEU A 403
SER A 391
THR A 393
 None
 1.04A 4ikkA-2rjtA:
undetectable
4ikkB-2rjtA:
undetectable		 4ikkA-2rjtA:
14.32
4ikkB-2rjtA:
14.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		7 / 12 ALA A 163
CYH A 164
SER A 194
HIS A 303
THR A 305
HIS A 337
GLY A 395
 None
 1.10A 4ls7A-2rjtA:
68.8		 4ls7A-2rjtA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		10 / 12 GLY A 108
ALA A 163
CYH A 164
GLU A 192
PHE A 203
HIS A 303
THR A 305
HIS A 337
LEU A 339
GLY A 395
 None
 0.56A 4ls7A-2rjtA:
68.8		 4ls7A-2rjtA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		7 / 12 GLY A 108
ALA A 163
GLU A 192
PHE A 203
LEU A 339
GLY A 395
PHE A 396
 None
 0.61A 4ls7A-2rjtA:
68.8		 4ls7A-2rjtA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		7 / 12 GLY A 340
ALA A 163
CYH A 164
GLU A 192
PHE A 203
LEU A 339
GLY A 395
 None
 1.50A 4ls7A-2rjtA:
68.8		 4ls7A-2rjtA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		8 / 12 ALA A 163
CYH A 164
PHE A 203
HIS A 303
THR A 305
HIS A 337
LEU A 339
GLY A 395
 None
 0.59A 4ls7A-2rjtA:
68.8
4ls7B-2rjtA:
68.7		 4ls7A-2rjtA:
46.30
4ls7B-2rjtA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		7 / 12 ALA A 163
CYH A 164
SER A 194
HIS A 303
THR A 305
HIS A 337
GLY A 395
 None
 1.09A 4ls7A-2rjtA:
68.8
4ls7B-2rjtA:
68.7		 4ls7A-2rjtA:
46.30
4ls7B-2rjtA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 ALA A 163
PHE A 203
LEU A 339
GLY A 395
PHE A 396
 None
 0.69A 4ls7A-2rjtA:
68.8
4ls7B-2rjtA:
68.7		 4ls7A-2rjtA:
46.30
4ls7B-2rjtA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		6 / 12 ILE A 109
ALA A 163
CYH A 164
PHE A 203
HIS A 303
GLY A 395
 None
 0.73A 4ls7A-2rjtA:
68.8
4ls7B-2rjtA:
68.7		 4ls7A-2rjtA:
46.30
4ls7B-2rjtA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 ILE A 109
ALA A 163
PHE A 203
GLY A 395
PHE A 396
 None
 0.89A 4ls7A-2rjtA:
68.8
4ls7B-2rjtA:
68.7		 4ls7A-2rjtA:
46.30
4ls7B-2rjtA:
46.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 ILE A 390
VAL A 402
GLY A 278
ALA A 279
LEU A 322
 None
 0.72A 4o1zA-2rjtA:
undetectable		 4o1zA-2rjtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		4 / 6 VAL A  93
LEU A  91
LEU A 187
PHE A  63
 None
 1.01A 4o1zA-2rjtA:
undetectable		 4o1zA-2rjtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 THR A 331
SER A 330
GLY A  34
PHE A  24
GLY A 234
 None
 1.38A 4uinH-2rjtA:
undetectable
4uinL-2rjtA:
undetectable		 4uinH-2rjtA:
19.85
4uinL-2rjtA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		4 / 4 GLY A 228
VAL A 230
PHE A  46
ILE A 200
 None
 1.16A 4xv2B-2rjtA:
undetectable		 4xv2B-2rjtA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		4 / 7 LEU A 238
GLY A 172
ALA A 174
ILE A 160
 None
 0.71A 4yjiA-2rjtA:
undetectable		 4yjiA-2rjtA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		4 / 6 ILE A 372
PHE A 222
ILE A 318
GLU A 314
 None
 0.97A 4zzcA-2rjtA:
undetectable
4zzcB-2rjtA:
undetectable		 4zzcA-2rjtA:
22.20
4zzcB-2rjtA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		4 / 6 ILE A 372
PHE A 222
ILE A 318
GLU A 314
 None
 1.04A 4zzcB-2rjtA:
undetectable
4zzcC-2rjtA:
undetectable		 4zzcB-2rjtA:
22.20
4zzcC-2rjtA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		4 / 5 THR A 263
GLY A 278
GLU A 314
HIS A 303
 None
 1.22A 5c0oH-2rjtA:
undetectable		 5c0oH-2rjtA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 10 ALA A 374
ILE A 372
TYR A 371
GLY A 304
GLY A 316
 None
 1.20A 5i6xA-2rjtA:
undetectable		 5i6xA-2rjtA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		4 / 7 LEU A 322
ILE A 351
THR A 350
MET A 354
 None
 1.38A 5ljcA-2rjtA:
undetectable		 5ljcA-2rjtA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 THR A 335
THR A 393
LEU A 338
GLY A 232
HIS A 337
 None
 1.44A 5m66C-2rjtA:
undetectable		 5m66C-2rjtA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 12 ILE A 292
LEU A 322
VAL A 297
ILE A 390
PHE A 394
 None
 0.94A 5mueA-2rjtA:
undetectable		 5mueA-2rjtA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		5 / 9 ARG A 100
ILE A 104
GLY A 155
LEU A 240
ALA A 174
 None
 1.01A 5o96A-2rjtA:
undetectable
5o96B-2rjtA:
undetectable		 5o96A-2rjtA:
18.41
5o96B-2rjtA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		3 / 3 HIS A 337
GLU A 346
ASN A 168
 None
 0.98A 5wbvA-2rjtA:
undetectable		 5wbvA-2rjtA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		3 / 3 HIS A 337
GLU A 346
ASN A 168
 None
 0.98A 5wbvB-2rjtA:
undetectable		 5wbvB-2rjtA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		3 / 3 LEU A  96
LEU A  91
ARG A 249
 None
 0.61A 6fgcA-2rjtA:
1.2		 6fgcA-2rjtA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		3 / 3 LEU A  96
LEU A  91
ARG A 249
 None
 0.57A 6fgdA-2rjtA:
undetectable		 6fgdA-2rjtA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2rjt BETA-KETOACYL-ACP
SYNTHASE II
(Streptococcus
pneumoniae) 		3 / 3 THR A  30
GLU A 352
ASN A  26
 None
 0.77A 6nj9K-2rjtA:
undetectable		 6nj9K-2rjtA:
21.97