SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rk0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2rk0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
DOMAIN
(Frankia
sp.
EAN1pec) 		4 / 6 VAL A   9
LEU A  89
ILE A 111
LEU A  51
 None
 0.99A 3kk6A-2rk0A:
undetectable		 3kk6A-2rk0A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2rk0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
DOMAIN
(Frankia
sp.
EAN1pec) 		5 / 12 LEU A  76
LEU A 122
ALA A 121
LEU A  11
GLY A  72
 None
 1.01A 3olsA-2rk0A:
undetectable		 3olsA-2rk0A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2rk0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
DOMAIN
(Frankia
sp.
EAN1pec) 		5 / 12 LEU A  51
LEU A  47
LEU A  27
ILE A  53
TYR A  23
 None
 1.00A 4a7aB-2rk0A:
undetectable		 4a7aB-2rk0A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2rk0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
DOMAIN
(Frankia
sp.
EAN1pec) 		3 / 3 LEU A  76
LEU A  11
ARG A  70
 None
 0.61A 5hnzB-2rk0A:
undetectable		 5hnzB-2rk0A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 2rk0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
DOMAIN
(Frankia
sp.
EAN1pec) 		4 / 8 ILE A  53
LEU A  76
ALA A 124
LEU A  89
 None
 0.80A 5y7pE-2rk0A:
undetectable		 5y7pE-2rk0A:
18.56