SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rk5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2rk5 PUTATIVE HEMOLYSIN
(Streptococcus
mutans) 		5 / 11 LEU A  83
TYR A  43
VAL A  14
ILE A  13
HIS A  58
 None
 1.28A 1mrqA-2rk5A:
undetectable		 1mrqA-2rk5A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 2rk5 PUTATIVE HEMOLYSIN
(Streptococcus
mutans) 		5 / 12 VAL A  61
LEU A  68
LYS A  66
ILE A  85
PHE A  42
 None
 1.06A 2gj5A-2rk5A:
undetectable		 2gj5A-2rk5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 2rk5 PUTATIVE HEMOLYSIN
(Streptococcus
mutans) 		5 / 12 VAL A  14
ALA A  40
LEU A  20
PHE A  23
ILE A  85
 None
 1.13A 2w3vA-2rk5A:
undetectable		 2w3vA-2rk5A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2rk5 PUTATIVE HEMOLYSIN
(Streptococcus
mutans) 		4 / 5 GLN A   3
THR A  19
THR A  29
LEU A  70
 None
 1.39A 4lvcA-2rk5A:
undetectable		 4lvcA-2rk5A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2rk5 PUTATIVE HEMOLYSIN
(Streptococcus
mutans) 		4 / 5 GLN A   3
THR A  19
THR A  29
LEU A  70
 None
 1.37A 4lvcC-2rk5A:
undetectable		 4lvcC-2rk5A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2rk5 PUTATIVE HEMOLYSIN
(Streptococcus
mutans) 		5 / 12 ILE A  13
THR A  49
TYR A  43
VAL A  47
LEU A  83
 None
 1.36A 4qynA-2rk5A:
undetectable		 4qynA-2rk5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2rk5 PUTATIVE HEMOLYSIN
(Streptococcus
mutans) 		4 / 4 GLN A   3
THR A  19
THR A  29
LEU A  70
 None
 1.36A 5m5kA-2rk5A:
undetectable		 5m5kA-2rk5A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2rk5 PUTATIVE HEMOLYSIN
(Streptococcus
mutans) 		4 / 4 GLN A   3
THR A  19
THR A  29
LEU A  70
 None
 1.36A 5m5kC-2rk5A:
undetectable		 5m5kC-2rk5A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2rk5 PUTATIVE HEMOLYSIN
(Streptococcus
mutans) 		4 / 4 GLN A   3
THR A  19
THR A  29
LEU A  70
 None
 1.36A 5m66B-2rk5A:
undetectable		 5m66B-2rk5A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2rk5 PUTATIVE HEMOLYSIN
(Streptococcus
mutans) 		3 / 3 VAL A  80
VAL A  75
GLN A  53
 None
 0.71A 5qglA-2rk5A:
undetectable		 5qglA-2rk5A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2rk5 PUTATIVE HEMOLYSIN
(Streptococcus
mutans) 		3 / 3 VAL A  80
VAL A  75
GLN A  53
 None
 0.72A 5qhgA-2rk5A:
undetectable		 5qhgA-2rk5A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 2rk5 PUTATIVE HEMOLYSIN
(Streptococcus
mutans) 		4 / 4 GLN A   3
THR A  19
THR A  29
LEU A  70
 None
 1.35A 6f3mB-2rk5A:
undetectable		 6f3mB-2rk5A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 2rk5 PUTATIVE HEMOLYSIN
(Streptococcus
mutans) 		4 / 5 GLN A   3
THR A  19
THR A  29
LEU A  70
 None
 1.40A 6gbnD-2rk5A:
undetectable		 6gbnD-2rk5A:
12.87