SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rkb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 10 GLY A 203
GLY A 174
ALA A 275
THR A 201
HIS A 205
None
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
1.10A 1c9sL-2rkbA:
undetectable
1c9sV-2rkbA:
undetectable
1c9sL-2rkbA:
12.38
1c9sV-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 LEU A 297
GLY A 295
LEU A 288
VAL A 304
PRO A 195
None
1.10A 1dfoA-2rkbA:
undetectable
1dfoA-2rkbA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 LEU A 297
GLY A 295
LEU A 288
VAL A 304
PRO A 195
None
1.10A 1dfoB-2rkbA:
undetectable
1dfoB-2rkbA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 LEU A 297
GLY A 295
LEU A 288
VAL A 304
PRO A 195
None
1.09A 1dfoC-2rkbA:
undetectable
1dfoC-2rkbA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 LEU A 297
GLY A 295
LEU A 288
VAL A 304
PRO A 195
None
1.10A 1dfoD-2rkbA:
undetectable
1dfoD-2rkbA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 LEU A 297
GLY A 295
LEU A 288
VAL A 304
PRO A 195
None
1.11A 1eqbA-2rkbA:
undetectable
1eqbA-2rkbA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 LEU A 297
GLY A 295
LEU A 288
VAL A 304
PRO A 195
None
1.12A 1eqbB-2rkbA:
undetectable
1eqbB-2rkbA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 LEU A 297
GLY A 295
LEU A 288
VAL A 304
PRO A 195
None
1.11A 1eqbC-2rkbA:
undetectable
1eqbC-2rkbA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 LEU A 297
GLY A 295
LEU A 288
VAL A 304
PRO A 195
None
1.11A 1eqbD-2rkbA:
undetectable
1eqbD-2rkbA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 9 GLY A 203
GLY A 174
ALA A 275
THR A 201
HIS A 205
None
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
1.04A 1gtfD-2rkbA:
undetectable
1gtfE-2rkbA:
undetectable
1gtfD-2rkbA:
12.38
1gtfE-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 10 GLY A 203
GLY A 174
ALA A 275
THR A 201
HIS A 205
None
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
1.08A 1gtfJ-2rkbA:
undetectable
1gtfK-2rkbA:
undetectable
1gtfJ-2rkbA:
12.38
1gtfK-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 11 GLY A 174
ALA A 275
THR A 201
HIS A 205
GLY A 203
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
None
1.08A 1gtfQ-2rkbA:
undetectable
1gtfR-2rkbA:
undetectable
1gtfQ-2rkbA:
12.38
1gtfR-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 11 GLY A 174
ALA A 275
THR A 201
HIS A 205
GLY A 203
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
None
1.06A 1gtfS-2rkbA:
undetectable
1gtfT-2rkbA:
undetectable
1gtfS-2rkbA:
12.38
1gtfT-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 LEU A 106
ALA A  83
ALA A  80
VAL A 102
HIS A  66
None
1.27A 1kt4A-2rkbA:
undetectable
1kt4A-2rkbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 GLY A 174
ALA A 275
HIS A 205
GLY A 203
ALA A 226
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
None
0.95A 1utdL-2rkbA:
undetectable
1utdM-2rkbA:
undetectable
1utdL-2rkbA:
12.38
1utdM-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 11 GLY A 203
GLY A 174
ALA A 275
THR A 201
HIS A 205
None
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
1.08A 1utdL-2rkbA:
undetectable
1utdV-2rkbA:
undetectable
1utdL-2rkbA:
12.38
1utdV-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
4 / 8 PRO A 166
LEU A 186
GLY A 185
LEU A 169
None
0.94A 1ya4A-2rkbA:
undetectable
1ya4A-2rkbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 ALA A 172
GLY A 176
GLY A 175
LEU A 229
LEU A 219
PLP  A 400 ( 4.8A)
PLP  A 400 (-2.9A)
PLP  A 400 (-3.4A)
K  A 401 (-4.6A)
None
1.00A 1ya4A-2rkbA:
undetectable
1ya4A-2rkbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 8 GLY A 185
GLY A 181
ALA A 184
LEU A 178
ILE A 196
None
None
None
PLP  A 400 (-4.7A)
None
0.99A 1yajC-2rkbA:
undetectable
1yajC-2rkbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 11 ALA A 278
ALA A 231
GLY A 230
ALA A 204
ASP A 254
None
None
None
K  A 401 (-4.7A)
None
0.96A 2f16H-2rkbA:
undetectable
2f16I-2rkbA:
undetectable
2f16H-2rkbA:
21.17
2f16I-2rkbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 11 ALA A 278
ALA A 231
GLY A 230
ALA A 204
ASP A 254
None
None
None
K  A 401 (-4.7A)
None
0.96A 2f16V-2rkbA:
undetectable
2f16W-2rkbA:
undetectable
2f16V-2rkbA:
21.17
2f16W-2rkbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
3 / 3 HIS A 144
ILE A  52
LEU A  67
None
0.55A 2kceA-2rkbA:
undetectable
2kceA-2rkbA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
4 / 5 TYR A 284
LEU A  26
VAL A 306
VAL A 272
None
1.19A 2m56A-2rkbA:
undetectable
2m56A-2rkbA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 ALA A 279
GLY A 277
LEU A 171
VAL A 304
LEU A 297
None
0.93A 2nyuB-2rkbA:
undetectable
2nyuB-2rkbA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 10 LEU A 179
VAL A 173
GLY A 174
GLY A 181
ALA A 238
None
PLP  A 400 ( 4.1A)
PLP  A 400 ( 3.3A)
None
None
0.97A 2v3kA-2rkbA:
undetectable
2v3kA-2rkbA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 11 ALA A 278
ALA A 231
GLY A 230
ALA A 204
ASP A 254
None
None
None
K  A 401 (-4.7A)
None
0.95A 3mg0V-2rkbA:
undetectable
3mg0W-2rkbA:
undetectable
3mg0V-2rkbA:
21.17
3mg0W-2rkbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 ARG A 105
GLY A  76
GLY A  73
GLU A 109
ALA A  78
None
1.34A 3t7sC-2rkbA:
2.5
3t7sC-2rkbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
4 / 8 LEU A 280
VAL A  34
VAL A 170
TYR A 284
None
0.76A 3v81C-2rkbA:
undetectable
3v81C-2rkbA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
4 / 8 SER A  44
ASN A  74
GLY A  72
GLY A 108
None
PLP  A 400 (-3.3A)
None
None
0.88A 4fo4B-2rkbA:
undetectable
4fo4B-2rkbA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
4 / 4 ALA A  75
ALA A  78
ALA A  79
ALA A  82
None
0.13A 4oadA-2rkbA:
undetectable
4oadA-2rkbA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
4 / 4 ALA A  75
ALA A  78
ALA A  79
ALA A  82
None
0.13A 4oaeA-2rkbA:
undetectable
4oaeA-2rkbA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
4 / 8 LEU A 280
VAL A  34
VAL A 170
TYR A 284
None
0.78A 4puoC-2rkbA:
undetectable
4puoC-2rkbA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
4 / 8 LEU A 280
VAL A  34
VAL A 170
TYR A 284
None
0.75A 4pwdC-2rkbA:
1.6
4pwdC-2rkbA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 10 GLY A 203
GLY A 174
ALA A 275
THR A 201
HIS A 205
None
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
1.06A 5eevA-2rkbA:
undetectable
5eevB-2rkbA:
undetectable
5eevA-2rkbA:
12.38
5eevB-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 10 GLY A 203
GLY A 174
ALA A 275
THR A 201
HIS A 205
None
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
1.07A 5eewA-2rkbA:
undetectable
5eewB-2rkbA:
undetectable
5eewA-2rkbA:
12.38
5eewB-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 10 GLY A 203
GLY A 174
ALA A 275
THR A 201
HIS A 205
None
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
1.07A 5eexA-2rkbA:
undetectable
5eexB-2rkbA:
undetectable
5eexA-2rkbA:
12.38
5eexB-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 10 GLY A 203
GLY A 174
ALA A 275
THR A 201
HIS A 205
None
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
1.07A 5eeyA-2rkbA:
undetectable
5eeyB-2rkbA:
undetectable
5eeyA-2rkbA:
12.38
5eeyB-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 10 GLY A 203
GLY A 174
ALA A 275
THR A 201
HIS A 205
None
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
1.07A 5eezA-2rkbA:
undetectable
5eezB-2rkbA:
undetectable
5eezA-2rkbA:
12.38
5eezB-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 10 GLY A 203
GLY A 174
ALA A 275
THR A 201
HIS A 205
None
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
1.07A 5ef0A-2rkbA:
undetectable
5ef0B-2rkbA:
undetectable
5ef0A-2rkbA:
12.38
5ef0B-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 10 GLY A 203
GLY A 174
ALA A 275
THR A 201
HIS A 205
None
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
1.07A 5ef1A-2rkbA:
undetectable
5ef1B-2rkbA:
undetectable
5ef1A-2rkbA:
12.38
5ef1B-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 10 GLY A 203
GLY A 174
ALA A 275
THR A 201
HIS A 205
None
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
1.07A 5ef2A-2rkbA:
undetectable
5ef2B-2rkbA:
undetectable
5ef2A-2rkbA:
12.38
5ef2B-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 10 GLY A 203
GLY A 174
ALA A 275
THR A 201
HIS A 205
None
PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
1.07A 5ef3A-2rkbA:
undetectable
5ef3B-2rkbA:
undetectable
5ef3A-2rkbA:
12.38
5ef3B-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
4 / 4 VAL A 173
GLU A 200
GLY A 176
LEU A 179
PLP  A 400 ( 4.1A)
K  A 401 (-3.7A)
PLP  A 400 (-2.9A)
None
1.34A 5g5gC-2rkbA:
undetectable
5g5gC-2rkbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
4 / 5 CYH A 276
ILE A 307
CYH A 309
LEU A 280
None
None
PLP  A 400 (-3.6A)
None
1.48A 5hrqC-2rkbA:
undetectable
5hrqD-2rkbA:
undetectable
5hrqL-2rkbA:
undetectable
5hrqC-2rkbA:
5.28
5hrqD-2rkbA:
9.09
5hrqL-2rkbA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 LEU A 186
ILE A 307
LEU A 178
GLY A 177
LEU A 162
None
None
PLP  A 400 (-4.7A)
PLP  A 400 (-3.2A)
None
1.20A 5ienA-2rkbA:
undetectable
5ienA-2rkbA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 GLU A 256
LEU A  36
LEU A 264
ALA A 260
LEU A  26
None
0.92A 6b0cD-2rkbA:
undetectable
6b0cD-2rkbA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
2rkb SERINE
DEHYDRATASE-LIKE

(Homo
sapiens)
5 / 12 ALA A 278
ALA A 231
GLY A 230
ALA A 204
ASP A 254
None
None
None
K  A 401 (-4.7A)
None
0.97A 6hwdH-2rkbA:
undetectable
6hwdI-2rkbA:
undetectable
6hwdH-2rkbA:
14.38
6hwdI-2rkbA:
15.83