SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rkc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		4 / 8 ALA A 298
LEU A 324
LEU A 208
LEU A 205
 None
 0.91A 1dvtA-2rkcA:
undetectable
1dvtB-2rkcA:
undetectable		 1dvtA-2rkcA:
15.73
1dvtB-2rkcA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		4 / 8 GLY A 438
SER A 352
TYR A 410
HIS A 354
 None
 0.93A 1maaD-2rkcA:
undetectable		 1maaD-2rkcA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		5 / 11 PHE A 319
VAL A 367
GLY A 411
THR A 369
ILE A 306
 None
 1.05A 1phgA-2rkcA:
undetectable		 1phgA-2rkcA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		5 / 10 GLY A 229
VAL A 257
GLY A 258
MET A 272
THR A 221
 None
 1.30A 1v3qE-2rkcA:
undetectable		 1v3qE-2rkcA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		5 / 12 TYR A 350
PRO A 401
VAL A 478
ILE A 435
LEU A 454
 None
 1.18A 1z9hA-2rkcA:
undetectable		 1z9hA-2rkcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		5 / 12 TYR A 350
PRO A 401
VAL A 478
ILE A 435
LEU A 454
 None
 1.19A 1z9hB-2rkcA:
undetectable		 1z9hB-2rkcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		5 / 12 TYR A 350
PRO A 401
VAL A 478
ILE A 435
LEU A 454
 None
 1.18A 1z9hC-2rkcA:
undetectable		 1z9hC-2rkcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		4 / 6 ASP A 530
TYR A 529
TYR A 540
LEU A 526
 None
 1.02A 2w98A-2rkcA:
undetectable
2w98B-2rkcA:
undetectable		 2w98A-2rkcA:
20.86
2w98B-2rkcA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		4 / 6 LEU A 585
ILE A 594
PRO A 558
VAL A 515
 None
 1.06A 2ygoA-2rkcA:
undetectable		 2ygoA-2rkcA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		4 / 8 SER A 352
ASP A 442
VAL A 568
LEU A 566
 None
 1.15A 3jq7C-2rkcA:
undetectable		 3jq7C-2rkcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		4 / 6 SER A 204
PHE A 270
TYR A 228
PRO A 268
 None
 1.44A 3jqaA-2rkcA:
undetectable		 3jqaA-2rkcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		4 / 6 SER A 204
PHE A 270
TYR A 228
PRO A 268
 None
 1.45A 3jqaB-2rkcA:
undetectable		 3jqaB-2rkcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		4 / 6 SER A 204
PHE A 270
TYR A 228
PRO A 268
 None
 1.48A 3jqaC-2rkcA:
undetectable		 3jqaC-2rkcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		4 / 6 SER A 204
PHE A 270
TYR A 228
PRO A 268
 None
 1.45A 3jqaD-2rkcA:
undetectable		 3jqaD-2rkcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		5 / 12 SER A 414
ALA A 363
TYR A 452
LEU A 443
PHE A 476
 None
 1.36A 3qt0A-2rkcA:
0.0		 3qt0A-2rkcA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		4 / 4 LEU A 299
SER A 414
LEU A 339
LEU A 321
 None
 1.12A 4n09A-2rkcA:
undetectable		 4n09A-2rkcA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		4 / 4 ASN A 513
VAL A 525
THR A 455
ILE A 467
 None
 1.26A 4retA-2rkcA:
undetectable		 4retA-2rkcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		4 / 4 ASN A 513
VAL A 525
THR A 455
ILE A 467
 None
 1.26A 4retC-2rkcA:
undetectable		 4retC-2rkcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		3 / 3 ASN A 274
PHE A 255
TYR A 232
 None
 0.83A 4u15A-2rkcA:
undetectable		 4u15A-2rkcA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		5 / 9 ILE A 306
VAL A 367
THR A 369
ASP A 347
ILE A 427
 None
 1.16A 5lg3B-2rkcA:
0.0		 5lg3B-2rkcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		5 / 9 ILE A 306
VAL A 367
THR A 369
ASP A 347
ILE A 427
 None
 1.14A 5lg3C-2rkcA:
0.0		 5lg3C-2rkcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		5 / 9 ILE A 306
VAL A 367
THR A 369
ASP A 347
ILE A 427
 None
 1.17A 5lg3D-2rkcA:
undetectable		 5lg3D-2rkcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		5 / 10 ILE A 306
VAL A 367
THR A 369
ASP A 347
ILE A 427
 None
 1.13A 5lg3F-2rkcA:
undetectable		 5lg3F-2rkcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		5 / 10 ILE A 306
VAL A 367
THR A 369
ASP A 347
ILE A 427
 None
 1.16A 5lg3G-2rkcA:
undetectable		 5lg3G-2rkcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		5 / 10 ILE A 306
VAL A 367
THR A 369
ASP A 347
ILE A 427
 None
 1.13A 5lg3H-2rkcA:
undetectable		 5lg3H-2rkcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		5 / 12 ILE A 306
VAL A 367
THR A 369
ASP A 347
ILE A 427
 None
 1.17A 5lg3J-2rkcA:
undetectable		 5lg3J-2rkcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		4 / 5 ARG A 355
MET A 441
THR A 455
LEU A 454
 None
 1.30A 5z86J-2rkcA:
undetectable		 5z86J-2rkcA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 2rkc HEMAGGLUTININ
(Measles
morbillivirus) 		3 / 3 ASP A 347
SER A 429
SER A 409
 None
 0.80A 6mxtA-2rkcA:
undetectable		 6mxtA-2rkcA:
21.84