SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rkj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		6 / 11 GLY A 101
HIS A 110
HIS A 113
GLY A 270
ASP A 272
GLN A 273
 None
 0.89A 1jzsA-2rkjA:
undetectable		 1jzsA-2rkjA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		6 / 11 GLY A 101
HIS A 113
GLY A 270
ASP A 272
GLN A 273
LEU A 316
 None
 0.84A 1jzsA-2rkjA:
undetectable		 1jzsA-2rkjA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		5 / 11 HIS A 110
GLY A 112
HIS A 113
GLY A 270
ASP A 272
 None
 0.79A 1pg2A-2rkjA:
8.1		 1pg2A-2rkjA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		5 / 12 GLY A 112
VAL A 400
LEU A 117
LEU A 363
LEU A 399
 None
 1.03A 1ya4C-2rkjA:
undetectable		 1ya4C-2rkjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		5 / 11 HIS A 110
GLY A 112
HIS A 113
GLY A 270
ASP A 272
 None
 0.89A 2x1lA-2rkjA:
7.6		 2x1lA-2rkjA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		5 / 12 HIS A 110
GLY A 112
HIS A 113
GLY A 270
ASP A 272
 None
 0.87A 2x1lB-2rkjA:
6.0		 2x1lB-2rkjA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		5 / 11 HIS A 110
GLY A 112
HIS A 113
GLY A 270
ASP A 272
 None
 0.92A 2x1lC-2rkjA:
6.1		 2x1lC-2rkjA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		4 / 7 ILE A 369
THR A 373
ARG A  74
LEU A 361
 None
 0.99A 2xrhA-2rkjA:
undetectable		 2xrhA-2rkjA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		3 / 3 MET A 367
GLU A 358
ASP A 354
 None
 0.92A 3a25A-2rkjA:
2.6		 3a25A-2rkjA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		5 / 12 PHE A 325
PHE A 121
GLY A 195
ALA A 130
ILE A 268
 None
None
A  C  66 ( 4.5A)
None
None
 1.29A 3ld6B-2rkjA:
undetectable		 3ld6B-2rkjA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		3 / 3 THR A 391
VAL A 387
GLU A 410
 None
 0.42A 3v4tA-2rkjA:
undetectable
3v4tD-2rkjA:
undetectable		 3v4tA-2rkjA:
23.40
3v4tD-2rkjA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		4 / 8 ASN A  51
GLN A  53
THR A  93
TRP A  52
 None
 1.18A 4d1yA-2rkjA:
2.0
4d1yB-2rkjA:
2.1		 4d1yA-2rkjA:
18.66
4d1yB-2rkjA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		4 / 8 ILE A 196
ILE A 166
LEU A 109
ILE A 102
 C  C  65 ( 4.2A)
None
None
None
 0.78A 4dtaB-2rkjA:
undetectable		 4dtaB-2rkjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		4 / 8 LEU A 117
VAL A 400
VAL A 177
LEU A 109
 None
 0.84A 4puoC-2rkjA:
undetectable		 4puoC-2rkjA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		4 / 8 LEU A 117
VAL A 400
VAL A 177
LEU A 109
 None
 0.90A 4pwdA-2rkjA:
undetectable		 4pwdA-2rkjA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		4 / 4 TYR A 274
THR A  80
GLY A 311
LEU A 281
 None
 1.38A 4w5nA-2rkjA:
undetectable		 4w5nA-2rkjA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		4 / 6 TYR A 124
TRP A 174
LEU A 173
LEU A 117
 None
 1.33A 5xooA-2rkjA:
undetectable		 5xooA-2rkjA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rkj TYROSYL-TRNA
SYNTHETASE
(Neurospora
crassa) 		4 / 5 TYR A 124
ARG A 194
MET A 181
THR A 179
 None
 1.40A 6nknW-2rkjA:
undetectable		 6nknW-2rkjA:
11.30