SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 319
LEU A 401
THR A 315
THR A 306
ILE A 310
 None
 1.27A 1hzeA-2rkoA:
undetectable
1hzeB-2rkoA:
undetectable		 1hzeA-2rkoA:
15.41
1hzeB-2rkoA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 9 THR A 306
ILE A 310
LEU A 319
LEU A 401
THR A 315
 None
 1.27A 1hzeA-2rkoA:
undetectable
1hzeB-2rkoA:
undetectable		 1hzeA-2rkoA:
15.41
1hzeB-2rkoA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 178
TYR A 181
SER A 180
 None
 0.78A 2xatA-2rkoA:
2.1		 2xatA-2rkoA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 346
LEU A 319
LEU A 401
LEU A 327
MET A 330
 None
 0.88A 3erdA-2rkoA:
undetectable		 3erdA-2rkoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 346
LEU A 319
LEU A 401
LEU A 327
MET A 330
 None
 0.89A 3erdB-2rkoA:
undetectable		 3erdB-2rkoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 202
LYS A 212
GLN A 259
LEU A 213
 None
 1.13A 3h5gA-2rkoA:
undetectable
3h5gB-2rkoA:
undetectable		 3h5gA-2rkoA:
6.65
3h5gB-2rkoA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 327
PHE A 308
ILE A 339
THR A 413
 None
 1.11A 3mdrA-2rkoA:
undetectable		 3mdrA-2rkoA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 308
VAL A 342
ILE A 410
SER A 335
 None
 1.00A 3pglA-2rkoA:
undetectable		 3pglA-2rkoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 346
LEU A 319
LEU A 401
LEU A 327
MET A 330
 None
 0.91A 4zn7B-2rkoA:
undetectable		 4zn7B-2rkoA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 145
ILE A 169
GLY A 274
ILE A 228
LEU A 237
 None
 0.79A 5ycnA-2rkoA:
undetectable		 5ycnA-2rkoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 398
THR A 315
PRO A 316
PRO A 350
 None
 0.96A 6a4iB-2rkoA:
undetectable		 6a4iB-2rkoA:
24.64