SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rkq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 2rkq PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-SD
(Drosophila
melanogaster) 		3 / 3 ALA A  18
VAL A  15
TRP A  20
 None
 0.85A 1bdwA-2rkqA:
undetectable
1bdwB-2rkqA:
undetectable		 1bdwA-2rkqA:
4.17
1bdwB-2rkqA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 2rkq PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-SD
(Drosophila
melanogaster) 		4 / 5 ILE A 109
SER A  91
ARG A  90
LEU A 107
 None
 1.09A 1y0xX-2rkqA:
undetectable		 1y0xX-2rkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 2rkq PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-SD
(Drosophila
melanogaster) 		4 / 6 PRO A 101
LEU A 178
ARG A  95
GLY A 105
 None
 1.21A 2hs2B-2rkqA:
undetectable		 2hs2B-2rkqA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 2rkq PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-SD
(Drosophila
melanogaster) 		3 / 3 LEU A  35
PRO A  36
ARG A  95
 None
 0.59A 2qd4B-2rkqA:
2.2		 2qd4B-2rkqA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2rkq PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-SD
(Drosophila
melanogaster) 		5 / 12 ALA A  41
HIS A  42
LEU A 163
GLY A 149
LEU A 141
 None
 1.23A 3tm4A-2rkqA:
undetectable		 3tm4A-2rkqA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2rkq PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-SD
(Drosophila
melanogaster) 		5 / 12 ALA A  41
HIS A  42
LEU A 163
GLY A 149
LEU A 141
 None
 1.24A 3tm4B-2rkqA:
undetectable		 3tm4B-2rkqA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2rkq PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-SD
(Drosophila
melanogaster) 		5 / 12 GLY A 113
GLY A  46
ALA A 110
ARG A 118
ILE A  80
 None
 1.05A 4krhA-2rkqA:
undetectable		 4krhA-2rkqA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2rkq PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-SD
(Drosophila
melanogaster) 		5 / 12 GLY A 113
GLY A  46
ALA A 110
ARG A 118
ILE A  80
 None
 1.06A 4krhB-2rkqA:
undetectable		 4krhB-2rkqA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2rkq PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-SD
(Drosophila
melanogaster) 		3 / 3 ASN A 114
LEU A  61
PHE A 111
 None
 0.81A 5dsgA-2rkqA:
undetectable		 5dsgA-2rkqA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2rkq PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-SD
(Drosophila
melanogaster) 		5 / 9 ALA A 162
GLY A 113
PHE A 115
SER A 158
GLY A 160
 None
 1.25A 6awoA-2rkqA:
undetectable		 6awoA-2rkqA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2rkq PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-SD
(Drosophila
melanogaster) 		5 / 9 ALA A 162
GLY A 113
PHE A 115
SER A 158
GLY A 160
 None
 1.25A 6awqA-2rkqA:
undetectable		 6awqA-2rkqA:
13.53