SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rkv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		3 / 3 TRP A 270
ALA A 369
VAL A 375
 None
 0.88A 1c4dA-2rkvA:
undetectable
1c4dB-2rkvA:
undetectable		 1c4dA-2rkvA:
4.59
1c4dB-2rkvA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 10 LEU A 141
VAL A  29
TYR A  27
GLY A 147
LEU A 392
 None
 1.14A 1fk9A-2rkvA:
1.4		 1fk9A-2rkvA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 10 LEU A 141
VAL A  29
TYR A  27
GLY A 147
LEU A 392
 None
 1.20A 1ikwA-2rkvA:
1.8		 1ikwA-2rkvA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		3 / 3 ASN A 189
PHE A 180
VAL A  53
 None
 0.74A 1kijA-2rkvA:
undetectable		 1kijA-2rkvA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 10 LEU A 141
VAL A  29
TYR A  27
GLY A 147
LEU A 392
 None
 1.19A 1lw0A-2rkvA:
1.8		 1lw0A-2rkvA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		4 / 7 PHE A 390
TYR A  27
LEU A  25
TYR A 388
 None
 1.25A 1rmtB-2rkvA:
undetectable		 1rmtB-2rkvA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		4 / 7 ALA A  95
ILE A 144
ASP A  92
ILE A 116
 None
 1.00A 1yc5A-2rkvA:
undetectable		 1yc5A-2rkvA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 12 LEU A 244
LEU A 327
THR A 249
THR A 261
ALA A 264
 None
None
None
COA  A 452 (-3.7A)
None
 0.77A 2egvA-2rkvA:
undetectable		 2egvA-2rkvA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 12 LEU A 244
LEU A 327
THR A 249
THR A 261
ALA A 264
 None
None
None
COA  A 452 (-3.7A)
None
 0.76A 2egvB-2rkvA:
undetectable		 2egvB-2rkvA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 11 GLN A 211
ALA A 218
GLY A 219
ALA A 369
CYH A 290
 None
 1.10A 2f16H-2rkvA:
undetectable
2f16I-2rkvA:
undetectable		 2f16H-2rkvA:
19.78
2f16I-2rkvA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 11 GLN A 211
ALA A 218
GLY A 219
ALA A 369
CYH A 290
 None
 1.09A 2f16V-2rkvA:
undetectable
2f16W-2rkvA:
undetectable		 2f16V-2rkvA:
19.78
2f16W-2rkvA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		4 / 6 ASN A 356
HIS A 355
ILE A 212
THR A   9
 None
 1.24A 2hkkA-2rkvA:
undetectable		 2hkkA-2rkvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 10 LEU A 141
VAL A  29
TYR A  27
GLY A 147
LEU A 392
 None
 1.20A 2hndA-2rkvA:
0.8		 2hndA-2rkvA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		4 / 6 LEU A 429
ILE A 269
VAL A 375
ALA A 273
 None
 1.02A 2j5mA-2rkvA:
undetectable		 2j5mA-2rkvA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		4 / 7 PHE A 233
VAL A 450
THR A  97
GLY A 105
 None
 1.01A 3gssA-2rkvA:
undetectable		 3gssA-2rkvA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 11 GLN A 211
ALA A 218
GLY A 219
ALA A 369
CYH A 290
 None
 1.17A 3mg0H-2rkvA:
undetectable
3mg0I-2rkvA:
undetectable		 3mg0H-2rkvA:
19.78
3mg0I-2rkvA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 11 GLN A 211
ALA A 218
GLY A 219
ALA A 369
CYH A 290
 None
 1.17A 3mg0V-2rkvA:
undetectable
3mg0W-2rkvA:
undetectable		 3mg0V-2rkvA:
19.78
3mg0W-2rkvA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 12 ALA A  57
PHE A  49
LEU A  46
ILE A 168
LEU A 139
 None
 1.13A 3nrrA-2rkvA:
undetectable		 3nrrA-2rkvA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 9 LEU A 141
VAL A  29
TYR A  27
GLY A 147
LEU A 392
 None
 1.10A 4b3oA-2rkvA:
2.0		 4b3oA-2rkvA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		3 / 3 SER A 410
MET A 412
ASP A 435
 None
 0.86A 4mm4B-2rkvA:
undetectable		 4mm4B-2rkvA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		3 / 3 ARG A 436
ASP A 440
ARG A 275
 None
 0.60A 4wq4B-2rkvA:
undetectable		 4wq4B-2rkvA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		4 / 8 ARG A 335
VAL A 259
ASP A 262
ASP A 263
 COA  A 452 (-2.9A)
None
COA  A 452 ( 3.6A)
COA  A 452 ( 4.3A)
 1.16A 4xqgA-2rkvA:
undetectable		 4xqgA-2rkvA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		4 / 8 ARG A 335
VAL A 259
ASP A 262
ASP A 263
 COA  A 452 (-2.9A)
None
COA  A 452 ( 3.6A)
COA  A 452 ( 4.3A)
 1.16A 4xqgB-2rkvA:
undetectable		 4xqgB-2rkvA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 10 ASN A 189
VAL A  53
VAL A  56
LEU A 170
ALA A 166
 None
 1.47A 4yhaB-2rkvA:
undetectable		 4yhaB-2rkvA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 11 GLN A 211
ALA A 218
GLY A 219
ALA A 369
CYH A 290
 None
 1.10A 5bxnH-2rkvA:
undetectable
5bxnI-2rkvA:
undetectable		 5bxnH-2rkvA:
20.53
5bxnI-2rkvA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 11 GLN A 211
ALA A 218
GLY A 219
ALA A 369
CYH A 290
 None
 1.09A 5bxnV-2rkvA:
undetectable
5bxnW-2rkvA:
undetectable		 5bxnV-2rkvA:
20.53
5bxnW-2rkvA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 12 GLN A 211
ALA A 218
GLY A 219
ALA A 369
CYH A 290
 None
 1.20A 5l5fH-2rkvA:
undetectable
5l5fI-2rkvA:
undetectable		 5l5fH-2rkvA:
20.31
5l5fI-2rkvA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 12 GLN A 211
ALA A 218
GLY A 219
ALA A 369
CYH A 290
 None
 1.20A 5l5fV-2rkvA:
undetectable
5l5fW-2rkvA:
undetectable		 5l5fV-2rkvA:
20.31
5l5fW-2rkvA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 12 GLN A 211
ALA A 218
GLY A 219
ALA A 369
CYH A 290
 None
 1.25A 5l5zH-2rkvA:
undetectable
5l5zI-2rkvA:
undetectable		 5l5zH-2rkvA:
20.31
5l5zI-2rkvA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 12 GLN A 211
ALA A 218
GLY A 219
ALA A 369
CYH A 290
 None
 1.27A 5l5zV-2rkvA:
undetectable
5l5zW-2rkvA:
undetectable		 5l5zV-2rkvA:
20.31
5l5zW-2rkvA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 12 GLN A 211
ALA A 218
GLY A 219
ALA A 369
CYH A 290
 None
 1.25A 5l66H-2rkvA:
undetectable
5l66I-2rkvA:
undetectable		 5l66H-2rkvA:
20.31
5l66I-2rkvA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 12 GLN A 211
ALA A 218
GLY A 219
ALA A 369
CYH A 290
 None
 1.25A 5l66V-2rkvA:
undetectable
5l66W-2rkvA:
undetectable		 5l66V-2rkvA:
20.31
5l66W-2rkvA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		3 / 3 ILE A 137
VAL A 167
PRO A 306
 None
 0.67A 5uunA-2rkvA:
undetectable		 5uunA-2rkvA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 10 LEU A 141
VAL A  29
TYR A  27
GLY A 147
LEU A 392
 None
 1.04A 6bsjA-2rkvA:
1.9		 6bsjA-2rkvA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		5 / 12 TYR A 388
LEU A 392
GLY A 391
ARG A 176
ASP A 178
 None
 1.31A 6bxlB-2rkvA:
undetectable		 6bxlB-2rkvA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
graminearum) 		4 / 6 LEU A 171
LEU A 392
THR A 151
ARG A  90
 None
 0.82A 6ew0G-2rkvA:
undetectable		 6ew0G-2rkvA:
11.59