SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rli'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R30_A_SAMA501_0 (BIOTIN SYNTHASE)	2rli	SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL (Homo sapiens)	5 / 12	PRO A 162 GLY A 242 ILE A 165 LEU A 191 LEU A 141	None	1.17A	1r30A-2rliA: undetectable	1r30A-2rliA: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R30_B_SAMB501_0 (BIOTIN SYNTHASE)	2rli	SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL (Homo sapiens)	5 / 12	PRO A 162 GLY A 242 ILE A 165 LEU A 191 LEU A 141	None	1.18A	1r30B-2rliA: undetectable	1r30B-2rliA: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RE7_B_FOLB361_0 (DIHYDROFOLATE REDUCTASE)	2rli	SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL (Homo sapiens)	5 / 12	ASP A 139 ILE A 228 LEU A 125 PRO A 162 ILE A 250	None	1.24A	1re7B-2rliA: undetectable	1re7B-2rliA: 21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BM9_D_SAMD301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	2rli	SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL (Homo sapiens)	5 / 12	LEU A 125 LEU A 144 LYS A 143 GLY A 242 ALA A 227	None	1.15A	2bm9D-2rliA: undetectable	2bm9D-2rliA: 22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_E_SAME301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	2rli	SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL (Homo sapiens)	5 / 12	LEU A 125 LEU A 144 LYS A 143 GLY A 242 ALA A 227	None	1.14A	2br4E-2rliA: undetectable	2br4E-2rliA: 22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TL8_A_X2NA502_2 (PROTEIN CYP51)	2rli	SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL (Homo sapiens)	4 / 6	PRO A 162 LEU A 189 PHE A 164 LEU A 125	None	1.15A	5tl8A-2rliA: undetectable	5tl8A-2rliA: 18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6N91_A_DCFA401_1 (ADENOSINE DEAMINASE)	2rli	SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL (Homo sapiens)	4 / 4	HIS A 257 LEU A 144 TYR A 127 GLY A 242	None	1.20A	6n91A-2rliA: undetectable	6n91A-2rliA: 18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6N91_B_DCFB401_1 (ADENOSINE DEAMINASE)	2rli	SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL (Homo sapiens)	4 / 4	HIS A 257 LEU A 144 TYR A 127 GLY A 242	None	1.21A	6n91B-2rliA: undetectable	6n91B-2rliA: 18.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1R30_A_SAMA501_0","BIOTIN SYNTHASE","2rli","SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL","Homo sapiens",5,"PRO A 162;GLY A 242;ILE A 165;LEU A 191;LEU A 141","None","1.17A","1r30A-2rliA:undetectable","1r30A-2rliA:18.93"],["1R30_B_SAMB501_0","BIOTIN SYNTHASE","2rli","SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL","Homo sapiens",5,"PRO A 162;GLY A 242;ILE A 165;LEU A 191;LEU A 141","None","1.18A","1r30B-2rliA:undetectable","1r30B-2rliA:18.93"],["1RE7_B_FOLB361_0","DIHYDROFOLATE REDUCTASE","2rli","SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL","Homo sapiens",5,"ASP A 139;ILE A 228;LEU A 125;PRO A 162;ILE A 250","None","1.24A","1re7B-2rliA:undetectable","1re7B-2rliA:21.35"],["2BM9_D_SAMD301_0","CEPHALOSPORIN HYDROXYLASE CMCI","2rli","SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL","Homo sapiens",5,"LEU A 125;LEU A 144;LYS A 143;GLY A 242;ALA A 227","None","1.15A","2bm9D-2rliA:undetectable","2bm9D-2rliA:22.78"],["2BR4_E_SAME301_0","CEPHALOSPORIN HYDROXYLASE CMCI","2rli","SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL","Homo sapiens",5,"LEU A 125;LEU A 144;LYS A 143;GLY A 242;ALA A 227","None","1.14A","2br4E-2rliA:undetectable","2br4E-2rliA:22.78"],["5TL8_A_X2NA502_2","PROTEIN CYP51","2rli","SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL","Homo sapiens",4,"PRO A 162;LEU A 189;PHE A 164;LEU A 125","None","1.15A","5tl8A-2rliA:undetectable","5tl8A-2rliA:18.16"],["6N91_A_DCFA401_1","ADENOSINE DEAMINASE","2rli","SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL","Homo sapiens",4,"HIS A 257;LEU A 144;TYR A 127;GLY A 242","None","1.20A","6n91A-2rliA:undetectable","6n91A-2rliA:18.50"],["6N91_B_DCFB401_1","ADENOSINE DEAMINASE","2rli","SCO2 PROTEIN HOMOLOG, MITOCHONDRIAL","Homo sapiens",4,"HIS A 257;LEU A 144;TYR A 127;GLY A 242","None","1.21A","6n91B-2rliA:undetectable","6n91B-2rliA:18.50"]]