SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2rmc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
C
(Mus
musculus) 		4 / 5 PHE A  70
PHE A 146
PHE A  87
VAL A  40
 None
 1.23A 2lh6A-2rmcA:
undetectable		 2lh6A-2rmcA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 2rmc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
C
(Mus
musculus) 		3 / 3 TYR A  82
GLY A  84
PHE A 101
 None
 0.62A 2m2pB-2rmcA:
undetectable		 2m2pB-2rmcA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2rmc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
C
(Mus
musculus) 		4 / 7 ALA A  74
GLY A  76
ASP A  43
ARG A  53
 None
 0.79A 2uyqA-2rmcA:
undetectable		 2uyqA-2rmcA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2rmc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
C
(Mus
musculus) 		4 / 7 GLY A  99
GLN A 145
SER A  85
HIS A  88
 None
 1.18A 4ws0A-2rmcA:
undetectable		 4ws0A-2rmcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 2rmc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
C
(Mus
musculus) 		4 / 8 VAL A  40
ILE A  56
ILE A 176
PHE A 146
 None
 0.77A 5hw8H-2rmcA:
undetectable		 5hw8H-2rmcA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2rmc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
C
(Mus
musculus) 		5 / 10 PRO A 118
ALA A 135
GLY A 106
THR A 107
ALA A 137
 None
 1.34A 5vyhA-2rmcA:
undetectable		 5vyhA-2rmcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2rmc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
C
(Mus
musculus) 		5 / 12 ILE A 148
GLY A 130
ILE A 129
ILE A 176
ILE A  96
 None
 1.00A 6emuA-2rmcA:
undetectable		 6emuA-2rmcA:
21.52