SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2rml COPPER-TRANSPORTING
P-TYPE ATPASE COPA
(Bacillus
subtilis) 		4 / 8 GLY A  56
THR A  57
ALA A  58
ALA A  59
 None
 0.55A 2ej3C-2rmlA:
undetectable		 2ej3C-2rmlA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2rml COPPER-TRANSPORTING
P-TYPE ATPASE COPA
(Bacillus
subtilis) 		5 / 11 ALA A  58
ALA A  59
THR A  55
VAL A  34
LEU A  28
 None
 1.16A 4j6cA-2rmlA:
undetectable		 4j6cA-2rmlA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2rml COPPER-TRANSPORTING
P-TYPE ATPASE COPA
(Bacillus
subtilis) 		5 / 10 ALA A  58
ALA A  59
THR A  55
VAL A  34
LEU A  28
 None
 1.14A 4j6cB-2rmlA:
undetectable		 4j6cB-2rmlA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2rml COPPER-TRANSPORTING
P-TYPE ATPASE COPA
(Bacillus
subtilis) 		5 / 12 ALA A  58
ALA A  59
THR A  55
VAL A  34
LEU A  28
 None
 1.11A 4j6dA-2rmlA:
undetectable		 4j6dA-2rmlA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2rml COPPER-TRANSPORTING
P-TYPE ATPASE COPA
(Bacillus
subtilis) 		5 / 12 ALA A  58
ALA A  59
THR A  55
VAL A  34
LEU A  28
 None
 1.11A 4j6dB-2rmlA:
undetectable		 4j6dB-2rmlA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2rml COPPER-TRANSPORTING
P-TYPE ATPASE COPA
(Bacillus
subtilis) 		5 / 11 ALA A  58
ALA A  59
THR A  55
VAL A  34
LEU A  28
 None
 1.14A 4jbtB-2rmlA:
undetectable		 4jbtB-2rmlA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2rml COPPER-TRANSPORTING
P-TYPE ATPASE COPA
(Bacillus
subtilis) 		5 / 10 ILE A   8
VAL A  48
ALA A  59
ALA A  58
ILE A  60
 None
 1.03A 4lbgA-2rmlA:
undetectable		 4lbgA-2rmlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2rml COPPER-TRANSPORTING
P-TYPE ATPASE COPA
(Bacillus
subtilis) 		3 / 3 GLU A 144
TYR A 118
GLU A  74
 None
 0.82A 4ryaA-2rmlA:
undetectable		 4ryaA-2rmlA:
16.78