SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rmn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 2rmn TUMOR PROTEIN 63
(Homo
sapiens) 		5 / 11 PHE A 138
ILE A 172
TYR A 265
ILE A 226
PHE A 301
 None
 1.37A 1fkjA-2rmnA:
undetectable		 1fkjA-2rmnA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 2rmn TUMOR PROTEIN 63
(Homo
sapiens) 		3 / 3 SER A 271
GLU A 302
ASP A 316
 None
 0.54A 2avdB-2rmnA:
undetectable		 2avdB-2rmnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 2rmn TUMOR PROTEIN 63
(Homo
sapiens) 		3 / 3 CYH A 273
CYH A 269
HIS A 208
 ZN  A   1 (-2.2A)
ZN  A   1 (-2.1A)
ZN  A   1 (-3.3A)
 0.74A 2iwkA-2rmnA:
undetectable		 2iwkA-2rmnA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 2rmn TUMOR PROTEIN 63
(Homo
sapiens) 		3 / 3 CYH A 273
CYH A 269
HIS A 208
 ZN  A   1 (-2.2A)
ZN  A   1 (-2.1A)
ZN  A   1 (-3.3A)
 0.70A 2iwkB-2rmnA:
undetectable		 2iwkB-2rmnA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 2rmn TUMOR PROTEIN 63
(Homo
sapiens) 		5 / 10 LEU A 288
ALA A 188
VAL A 263
ILE A 174
VAL A 140
 None
 0.95A 2nnjA-2rmnA:
undetectable		 2nnjA-2rmnA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2rmn TUMOR PROTEIN 63
(Homo
sapiens) 		3 / 3 CYH A 205
CYH A 269
HIS A 208
 ZN  A   1 (-2.1A)
ZN  A   1 (-2.1A)
ZN  A   1 (-3.3A)
 0.85A 3dtuB-2rmnA:
undetectable		 3dtuB-2rmnA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2rmn TUMOR PROTEIN 63
(Homo
sapiens) 		3 / 3 CYH A 273
CYH A 269
HIS A 208
 ZN  A   1 (-2.2A)
ZN  A   1 (-2.1A)
ZN  A   1 (-3.3A)
 0.78A 3dtuB-2rmnA:
undetectable		 3dtuB-2rmnA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2rmn TUMOR PROTEIN 63
(Homo
sapiens) 		3 / 3 CYH A 205
CYH A 269
HIS A 208
 ZN  A   1 (-2.1A)
ZN  A   1 (-2.1A)
ZN  A   1 (-3.3A)
 0.84A 3dtuD-2rmnA:
undetectable		 3dtuD-2rmnA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2rmn TUMOR PROTEIN 63
(Homo
sapiens) 		3 / 3 CYH A 273
CYH A 269
HIS A 208
 ZN  A   1 (-2.2A)
ZN  A   1 (-2.1A)
ZN  A   1 (-3.3A)
 0.78A 3dtuD-2rmnA:
undetectable		 3dtuD-2rmnA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2rmn TUMOR PROTEIN 63
(Homo
sapiens) 		5 / 9 PRO A 181
GLY A 183
ALA A 184
ARG A 187
LEU A 288
 None
 1.23A 3ur0C-2rmnA:
undetectable		 3ur0C-2rmnA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 2rmn TUMOR PROTEIN 63
(Homo
sapiens) 		5 / 12 PHE A 138
ILE A 172
TYR A 265
ILE A 226
PHE A 301
 None
 1.29A 4drhA-2rmnA:
undetectable		 4drhA-2rmnA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 2rmn TUMOR PROTEIN 63
(Homo
sapiens) 		5 / 10 PHE A 138
ILE A 172
TYR A 265
ILE A 226
PHE A 301
 None
 1.27A 4laxA-2rmnA:
undetectable		 4laxA-2rmnA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2rmn TUMOR PROTEIN 63
(Homo
sapiens) 		5 / 12 PHE A 138
ILE A 172
TYR A 265
ILE A 226
PHE A 301
 None
 1.30A 6mkeB-2rmnA:
undetectable
6mkeC-2rmnA:
undetectable		 6mkeB-2rmnA:
17.65
6mkeC-2rmnA:
17.65