SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rnn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2rnn E3 SUMO-PROTEIN
LIGASE SIZ1
(Saccharomyces
cerevisiae) 		5 / 11 TYR A 101
ALA A  84
VAL A  49
LEU A  60
PHE A  67
 None
 1.36A 3jwqB-2rnnA:
undetectable
3jwqC-2rnnA:
undetectable		 3jwqB-2rnnA:
15.96
3jwqC-2rnnA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2rnn E3 SUMO-PROTEIN
LIGASE SIZ1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 104
LEU A  37
PHE A  87
ARG A  91
LEU A  60
 None
 1.05A 5ljeA-2rnnA:
undetectable		 5ljeA-2rnnA:
21.17