SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ro1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA
(Homo
sapiens) 		5 / 9 VAL A 765
LEU A 708
LEU A 747
ARG A 746
ALA A 762
 None
 1.13A 1pbfA-2ro1A:
undetectable		 1pbfA-2ro1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA
(Homo
sapiens) 		4 / 7 TYR A 755
PHE A 761
PHE A 792
ILE A 743
 None
 1.10A 2zseA-2ro1A:
undetectable		 2zseA-2ro1A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA
(Homo
sapiens) 		4 / 6 ARG A 706
GLU A 705
PHE A 761
PRO A 758
 None
 1.38A 3gclA-2ro1A:
undetectable		 3gclA-2ro1A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA
(Homo
sapiens) 		3 / 3 ARG A 767
ASP A 739
ASP A 764
 None
 0.67A 3jayA-2ro1A:
undetectable		 3jayA-2ro1A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA
(Homo
sapiens) 		4 / 5 GLY A 766
ILE A 785
LEU A 723
LEU A 747
 None
 0.86A 4o8fA-2ro1A:
undetectable		 4o8fA-2ro1A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA
(Homo
sapiens) 		5 / 12 LEU A 740
ILE A 743
VAL A 707
LEU A 788
PHE A 792
 None
 1.24A 4y0pA-2ro1A:
undetectable		 4y0pA-2ro1A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA
(Homo
sapiens) 		5 / 12 LEU A 740
ILE A 743
LEU A 788
PHE A 792
MET A 796
 None
 1.13A 4y0qA-2ro1A:
undetectable		 4y0qA-2ro1A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA
(Homo
sapiens) 		6 / 12 LEU A 740
ILE A 743
VAL A 707
LEU A 788
PHE A 792
MET A 796
 None
 1.25A 4y0sA-2ro1A:
undetectable		 4y0sA-2ro1A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA
(Homo
sapiens) 		4 / 6 HIS A 652
LEU A 649
CYH A 640
CYH A 666
 None
None
ZN  A 301 (-2.2A)
ZN  A 301 ( 2.2A)
 1.21A 5hrqD-2ro1A:
undetectable
5hrqG-2ro1A:
undetectable
5hrqH-2ro1A:
undetectable		 5hrqD-2ro1A:
11.67
5hrqG-2ro1A:
11.21
5hrqH-2ro1A:
11.67