SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rop'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2rop COPPER-TRANSPORTING
ATPASE 2
(Homo
sapiens) 		4 / 5 VAL A 164
LEU A 176
ILE A 126
LEU A 125
 None
 0.80A 4mghA-2ropA:
undetectable		 4mghA-2ropA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2rop COPPER-TRANSPORTING
ATPASE 2
(Homo
sapiens) 		5 / 9 LEU A  24
ILE A  42
GLU A  39
VAL A  35
GLU A  79
 None
 1.21A 5igzA-2ropA:
undetectable		 5igzA-2ropA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2rop COPPER-TRANSPORTING
ATPASE 2
(Homo
sapiens) 		3 / 3 VAL A  62
TYR A  64
GLN A  49
 None
 0.56A 5qgkA-2ropA:
undetectable		 5qgkA-2ropA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2rop COPPER-TRANSPORTING
ATPASE 2
(Homo
sapiens) 		3 / 3 VAL A  62
TYR A  64
GLN A  49
 None
 0.55A 5qgrA-2ropA:
undetectable		 5qgrA-2ropA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2rop COPPER-TRANSPORTING
ATPASE 2
(Homo
sapiens) 		3 / 3 VAL A  62
TYR A  64
GLN A  49
 None
 0.59A 5qgtA-2ropA:
undetectable		 5qgtA-2ropA:
20.70