SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rpb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2rpb HYPOTHETICAL
MEMBRANE PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 VAL A 164
VAL A 159
ILE A  73
ARG A 145
 None
 1.14A 1iepA-2rpbA:
undetectable		 1iepA-2rpbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2rpb HYPOTHETICAL
MEMBRANE PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 LEU A 150
PHE A 111
VAL A  94
ALA A 119
 None
 1.11A 2cizA-2rpbA:
undetectable		 2cizA-2rpbA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2rpb HYPOTHETICAL
MEMBRANE PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ALA A 144
ARG A 147
LYS A 160
 None
 1.03A 3kp3B-2rpbA:
undetectable		 3kp3B-2rpbA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2rpb HYPOTHETICAL
MEMBRANE PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A  75
ASP A  74
LEU A 146
ALA A 119
ARG A 163
 None
 1.13A 5nd7B-2rpbA:
undetectable		 5nd7B-2rpbA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2rpb HYPOTHETICAL
MEMBRANE PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 GLN A 120
THR A 121
THR A 154
LEU A 146
 None
 1.40A 6aphA-2rpbA:
undetectable		 6aphA-2rpbA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 2rpb HYPOTHETICAL
MEMBRANE PROTEIN
(Pyrococcus
horikoshii) 		4 / 4 GLN A 120
THR A 121
THR A 154
LEU A 146
 None
 1.43A 6f3mA-2rpbA:
undetectable		 6f3mA-2rpbA:
12.69