SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rq4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QPS_A_CHDA211_0 (CMER)	2rq4	CUG-BP- AND ETR-3-LIKE FACTOR 1 (Homo sapiens)	5 / 10	ALA A 430 PHE A 446 GLY A 445 ILE A 405 PHE A 424	None	1.43A	3qpsA-2rq4A: undetectable	3qpsA-2rq4A: 20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K36_A_SAMA504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	2rq4	CUG-BP- AND ETR-3-LIKE FACTOR 1 (Homo sapiens)	5 / 12	TYR A 449 GLU A 396 LEU A 476 VAL A 474 ILE A 459	None	1.08A	4k36A-2rq4A: undetectable	4k36A-2rq4A: 16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K37_A_SAMA504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	2rq4	CUG-BP- AND ETR-3-LIKE FACTOR 1 (Homo sapiens)	5 / 11	TYR A 449 GLU A 396 LEU A 476 VAL A 474 ILE A 459	None	1.06A	4k37A-2rq4A: undetectable	4k37A-2rq4A: 16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K39_A_SAMA504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	2rq4	CUG-BP- AND ETR-3-LIKE FACTOR 1 (Homo sapiens)	5 / 12	TYR A 449 GLU A 396 LEU A 476 VAL A 474 ILE A 459	None	1.03A	4k39A-2rq4A: undetectable	4k39A-2rq4A: 16.25

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3QPS_A_CHDA211_0","CMER","2rq4","CUG-BP- AND ETR-3-LIKE FACTOR 1","Homo sapiens",5,"ALA A 430;PHE A 446;GLY A 445;ILE A 405;PHE A 424","None","1.43A","3qpsA-2rq4A:undetectable","3qpsA-2rq4A:20.47"],["4K36_A_SAMA504_0","ANAEROBIC SULFATASE-MATURATING ENZYME","2rq4","CUG-BP- AND ETR-3-LIKE FACTOR 1","Homo sapiens",5,"TYR A 449;GLU A 396;LEU A 476;VAL A 474;ILE A 459","None","1.08A","4k36A-2rq4A:undetectable","4k36A-2rq4A:16.45"],["4K37_A_SAMA504_0","ANAEROBIC SULFATASE-MATURATING ENZYME","2rq4","CUG-BP- AND ETR-3-LIKE FACTOR 1","Homo sapiens",5,"TYR A 449;GLU A 396;LEU A 476;VAL A 474;ILE A 459","None","1.06A","4k37A-2rq4A:undetectable","4k37A-2rq4A:16.25"],["4K39_A_SAMA504_0","ANAEROBIC SULFATASE-MATURATING ENZYME","2rq4","CUG-BP- AND ETR-3-LIKE FACTOR 1","Homo sapiens",5,"TYR A 449;GLU A 396;LEU A 476;VAL A 474;ILE A 459","None","1.03A","4k39A-2rq4A:undetectable","4k39A-2rq4A:16.25"]]