SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		3 / 3 ASP A  16
ARG A   6
ILE A   8
 None
 0.88A 1a4gB-2rq6A:
undetectable		 1a4gB-2rq6A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		5 / 10 THR A  42
LEU A  24
LEU A  31
GLY A  32
VAL A  69
 None
 1.21A 3lxiA-2rq6A:
undetectable		 3lxiA-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		5 / 9 THR A  42
LEU A  24
LEU A  31
GLY A  32
VAL A  69
 None
 1.14A 4c9kA-2rq6A:
undetectable		 4c9kA-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		5 / 9 THR A  42
LEU A  24
LEU A  31
GLY A  32
VAL A  69
 None
 1.14A 4c9kB-2rq6A:
undetectable		 4c9kB-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		6 / 12 ILE A  76
THR A  42
LEU A  24
LEU A  31
GLY A  32
VAL A  69
 None
 1.10A 4c9lA-2rq6A:
undetectable		 4c9lA-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		5 / 12 ILE A  76
THR A  42
LEU A  24
GLY A  32
VAL A  69
 None
 1.02A 4c9lB-2rq6A:
undetectable		 4c9lB-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		5 / 12 ILE A  76
THR A  42
LEU A  24
LEU A  31
GLY A  32
 None
 0.96A 4c9lB-2rq6A:
undetectable		 4c9lB-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		5 / 10 THR A  42
LEU A  24
LEU A  31
GLY A  32
VAL A  69
 None
 1.18A 4c9nB-2rq6A:
undetectable		 4c9nB-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		6 / 12 ILE A  76
THR A  42
LEU A  24
LEU A  31
GLY A  32
VAL A  69
 None
 1.13A 4c9oA-2rq6A:
undetectable		 4c9oA-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		5 / 12 ILE A  76
THR A  42
LEU A  24
GLY A  32
VAL A  69
 None
 1.04A 4c9oB-2rq6A:
undetectable		 4c9oB-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		5 / 12 ILE A  76
THR A  42
LEU A  24
LEU A  31
GLY A  32
 None
 1.01A 4c9oB-2rq6A:
undetectable		 4c9oB-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		5 / 9 THR A  42
LEU A  24
LEU A  31
GLY A  32
VAL A  69
 None
 1.21A 4c9pA-2rq6A:
undetectable		 4c9pA-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		5 / 12 MET A  49
LEU A  24
ILE A  76
VAL A  78
LEU A  44
 None
 1.11A 4o1zB-2rq6A:
undetectable		 4o1zB-2rq6A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		4 / 8 ALA A  98
ALA A 121
ALA A 118
ALA A 102
 None
 0.68A 4twdF-2rq6A:
2.5
4twdG-2rq6A:
undetectable
4twdH-2rq6A:
undetectable
4twdI-2rq6A:
undetectable
4twdJ-2rq6A:
undetectable		 4twdF-2rq6A:
17.72
4twdG-2rq6A:
17.72
4twdH-2rq6A:
17.72
4twdI-2rq6A:
17.72
4twdJ-2rq6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		4 / 8 ALA A 118
ALA A 102
ALA A  98
ALA A 121
 None
 0.67A 4twdF-2rq6A:
2.5
4twdG-2rq6A:
undetectable
4twdH-2rq6A:
undetectable
4twdI-2rq6A:
undetectable
4twdJ-2rq6A:
undetectable		 4twdF-2rq6A:
17.72
4twdG-2rq6A:
17.72
4twdH-2rq6A:
17.72
4twdI-2rq6A:
17.72
4twdJ-2rq6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		4 / 8 ALA A 121
ALA A 118
ALA A 102
ALA A  98
 None
 0.73A 4twdF-2rq6A:
2.5
4twdG-2rq6A:
undetectable
4twdH-2rq6A:
undetectable
4twdI-2rq6A:
undetectable
4twdJ-2rq6A:
undetectable		 4twdF-2rq6A:
17.72
4twdG-2rq6A:
17.72
4twdH-2rq6A:
17.72
4twdI-2rq6A:
17.72
4twdJ-2rq6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2rq6 ATP SYNTHASE EPSILON
CHAIN
(Thermosynechococ
cus
elongatus) 		5 / 12 VAL A  74
ALA A  67
LEU A  31
THR A  42
GLY A  32
 None
 0.86A 5cswB-2rq6A:
undetectable		 5cswB-2rq6A:
17.48