SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rqa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2rqa ATP-DEPENDENT RNA
HELICASE DHX58
(Homo
sapiens) 		3 / 3 ASP A 568
VAL A 659
PRO A 656
 None
 0.76A 2avvA-2rqaA:
undetectable		 2avvA-2rqaA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2rqa ATP-DEPENDENT RNA
HELICASE DHX58
(Homo
sapiens) 		3 / 3 LEU A 554
MET A 638
ASP A 661
 None
 0.80A 4j7xB-2rqaA:
undetectable		 4j7xB-2rqaA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 2rqa ATP-DEPENDENT RNA
HELICASE DHX58
(Homo
sapiens) 		3 / 3 GLY A 542
PRO A 543
GLN A 546
 None
 0.53A 4oltB-2rqaA:
undetectable		 4oltB-2rqaA:
17.34