SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 4 LYS A 170
LEU A 206
ALA A 168
LEU A 174
 None
 1.50A 1f86A-2rqwA:
0.0		 1f86A-2rqwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.94A 4qvlK-2rqwA:
undetectable
4qvlL-2rqwA:
undetectable		 4qvlK-2rqwA:
20.37
4qvlL-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.94A 4qvlY-2rqwA:
undetectable
4qvlZ-2rqwA:
undetectable		 4qvlY-2rqwA:
20.37
4qvlZ-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.93A 4qvmK-2rqwA:
undetectable
4qvmL-2rqwA:
undetectable		 4qvmK-2rqwA:
20.37
4qvmL-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.92A 4qvmY-2rqwA:
undetectable
4qvmZ-2rqwA:
undetectable		 4qvmY-2rqwA:
20.37
4qvmZ-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.97A 4qvpK-2rqwA:
undetectable
4qvpL-2rqwA:
undetectable		 4qvpK-2rqwA:
20.83
4qvpL-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.97A 4qvpY-2rqwA:
undetectable
4qvpZ-2rqwA:
undetectable		 4qvpY-2rqwA:
20.83
4qvpZ-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.96A 4qvwK-2rqwA:
undetectable
4qvwL-2rqwA:
undetectable		 4qvwK-2rqwA:
20.37
4qvwL-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.96A 4qvwY-2rqwA:
undetectable
4qvwZ-2rqwA:
undetectable		 4qvwY-2rqwA:
20.37
4qvwZ-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.99A 4qw1K-2rqwA:
undetectable
4qw1L-2rqwA:
undetectable		 4qw1K-2rqwA:
20.37
4qw1L-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.99A 4qw1Y-2rqwA:
undetectable
4qw1Z-2rqwA:
undetectable		 4qw1Y-2rqwA:
20.37
4qw1Z-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.93A 4qw3K-2rqwA:
undetectable
4qw3L-2rqwA:
undetectable		 4qw3K-2rqwA:
19.91
4qw3L-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.93A 4qw3Y-2rqwA:
undetectable
4qw3Z-2rqwA:
undetectable		 4qw3Y-2rqwA:
19.91
4qw3Z-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.95A 5bxnK-2rqwA:
undetectable
5bxnL-2rqwA:
undetectable		 5bxnK-2rqwA:
20.37
5bxnL-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.96A 5bxnY-2rqwA:
undetectable
5bxnZ-2rqwA:
undetectable		 5bxnY-2rqwA:
20.37
5bxnZ-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.95A 5d0xK-2rqwA:
undetectable
5d0xL-2rqwA:
undetectable		 5d0xK-2rqwA:
20.37
5d0xL-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.95A 5d0xY-2rqwA:
undetectable
5d0xZ-2rqwA:
undetectable		 5d0xY-2rqwA:
20.37
5d0xZ-2rqwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.95A 6hwdK-2rqwA:
undetectable
6hwdL-2rqwA:
undetectable		 6hwdK-2rqwA:
18.35
6hwdL-2rqwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rqw BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 175
ALA A 168
GLY A 202
GLY A 203
ASP A 172
 None
 0.93A 6hwdY-2rqwA:
undetectable
6hwdZ-2rqwA:
undetectable		 6hwdY-2rqwA:
18.35
6hwdZ-2rqwA:
20.00