SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rqx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2rqx POLYMYXIN B
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		3 / 3 TRP A   3
HIS A  70
MET A  28
 None
 1.24A 1l5qB-2rqxA:
undetectable		 1l5qB-2rqxA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 2rqx POLYMYXIN B
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 ILE A  65
ARG A  52
LEU A  63
ASP A  50
 None
 1.05A 2rlfA-2rqxA:
undetectable
2rlfD-2rqxA:
undetectable		 2rlfA-2rqxA:
19.54
2rlfD-2rqxA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2rqx POLYMYXIN B
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 ARG A  38
ASP A  43
LEU A  39
ILE A  32
 None
 1.01A 4k0bA-2rqxA:
undetectable		 4k0bA-2rqxA:
11.63