SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rrf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JMN_B_FUAB1101_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	2rrf	ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21 (Homo sapiens)	4 / 5	ILE A 58 LEU A 18 HIS A 123 VAL A 66	None	1.21A	5jmnB-2rrfA: undetectable	5jmnB-2rrfA: 9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KXI_A_NCTA402_1 (NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2)	2rrf	ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21 (Homo sapiens)	4 / 8	TYR A 89 THR A 27 CYH A 39 LEU A 102	None	1.12A	5kxiA-2rrfA: undetectable 5kxiB-2rrfA: undetectable	5kxiA-2rrfA: 15.62 5kxiB-2rrfA: 16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KXI_D_NCTD402_1 (NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2)	2rrf	ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21 (Homo sapiens)	4 / 8	TYR A 89 THR A 27 CYH A 39 LEU A 102	None	1.04A	5kxiD-2rrfA: undetectable 5kxiE-2rrfA: undetectable	5kxiD-2rrfA: 15.62 5kxiE-2rrfA: 16.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["5JMN_B_FUAB1101_1","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","2rrf","ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21","Homo sapiens",4,"ILE A  58;LEU A  18;HIS A 123;VAL A  66","None","1.21A","5jmnB-2rrfA:undetectable","5jmnB-2rrfA:9.94"],["5KXI_A_NCTA402_1","NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2","2rrf","ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21","Homo sapiens",4,"TYR A  89;THR A  27;CYH A  39;LEU A 102","None","1.12A","5kxiA-2rrfA:undetectable;5kxiB-2rrfA:undetectable","5kxiA-2rrfA:15.62;5kxiB-2rrfA:16.79"],["5KXI_D_NCTD402_1","NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2","2rrf","ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21","Homo sapiens",4,"TYR A  89;THR A  27;CYH A  39;LEU A 102","None","1.04A","5kxiD-2rrfA:undetectable;5kxiE-2rrfA:undetectable","5kxiD-2rrfA:15.62;5kxiE-2rrfA:16.79"]]