SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rrk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2rrk CTP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 4 ALA A  88
VAL A  72
ALA A  73
HIS A  75
 None
 1.01A 1q23A-2rrkA:
undetectable		 1q23A-2rrkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2rrk CTP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 4 ALA A  88
VAL A  72
ALA A  73
HIS A  75
 None
 0.95A 1q23F-2rrkA:
undetectable		 1q23F-2rrkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2rrk CTP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 4 ALA A  88
VAL A  72
ALA A  73
HIS A  75
 None
 1.17A 1q23K-2rrkA:
undetectable		 1q23K-2rrkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 2rrk CTP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		4 / 7 LEU A  62
GLU A  57
ALA A  14
ALA A  25
 None
 0.95A 1sn0B-2rrkA:
undetectable
1sn0D-2rrkA:
undetectable		 1sn0B-2rrkA:
22.73
1sn0D-2rrkA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2rrk CTP
PYROPHOSPHOHYDROLASE
(Escherichia
coli) 		5 / 11 GLY A  96
ALA A  66
LEU A  58
GLY A  63
ALA A 122
 None
 1.20A 4l6v1-2rrkA:
undetectable
4l6v6-2rrkA:
undetectable		 4l6v1-2rrkA:
10.39
4l6v6-2rrkA:
21.29