SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rrn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2rrn PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 6 PHE A 525
GLU A 494
ARG A 523
ILE A 512
 None
 1.49A 1nsiA-2rrnA:
undetectable
1nsiB-2rrnA:
undetectable		 1nsiA-2rrnA:
10.83
1nsiB-2rrnA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2rrn PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 7 PHE A 525
GLU A 494
ARG A 523
ILE A 512
 None
 1.48A 4nosA-2rrnA:
undetectable
4nosB-2rrnA:
undetectable		 4nosA-2rrnA:
11.35
4nosB-2rrnA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2rrn PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 7 ARG A 523
ILE A 512
PHE A 525
GLU A 494
 None
 1.47A 4nosC-2rrnA:
undetectable
4nosD-2rrnA:
undetectable		 4nosC-2rrnA:
11.35
4nosD-2rrnA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2rrn PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 6 PHE A 525
GLU A 494
ARG A 523
ILE A 512
 None
 1.45A 4nosC-2rrnA:
undetectable
4nosD-2rrnA:
undetectable		 4nosC-2rrnA:
11.35
4nosD-2rrnA:
11.35